3.4.21.119: kallikrein 13

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For detailed information about kallikrein 13, go to the full flat file.

Reaction

Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin =

Synonyms

GK-13, glandular kallikrein 13, glandular kallikrein K13, hK13, K13, kallikrein-related peptidase 13, KLK13, MGK-13, mK13, More, PRECE, prorenin converting enzyme, prorenin-converting enzyme, S01.306, tissue kallikrein

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.119 kallikrein 13

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Results	in table
5	Activating Compound
2	AA Sequence
11	Application
2	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
98	Disease/ Diagnostics
3	Expression
4	General Information
1	General Stability
2	IC50 Value
12	Inhibitors
8	kcat/KM [mM/s]
8	KM Value [mM]
6	Localization
1	Metals/Ions
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
23	Organism
5	pH Optimum
1	pI Value
2	Posttranslational Modification
1	Protein Variants
5	Purification (Commentary)
7	Reaction
1	Reaction Type
23	Reference
79	Source Tissue
1	Specific Activity [micromol/min/mg]
49	Substrates and Products (Substrate)
7	Subunits
28	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.119 - kallikrein 13

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0053 - 0.031

Abz-KLKSSKQ-EDDnp

2 entries

0.0012 - 0.0022

Abz-KLRSSKQ-EDDnp

2 entries

0.018

ABZ-Val-Arg-Phe-Arg-5-amino-2-nitrobenzoic acid

Homo sapiens

Q9UKR3

pH 7.5, 37°C

753922

0.02

ABZ-VRFRSTG-Tyr(3-NO2)-NH2

Homo sapiens

Q9UKR3

pH 7.5, 37°C

753922

0.01

ABZ-VRFRSTQ-Tyr(3-NO2)-NH2

Homo sapiens

Q9UKR3

pH 7.5, 37°C

753922

0.015

ABZ-VRFRSTS-Tyr(3-NO2)-NH2

Homo sapiens

Q9UKR3

pH 7.5, 37°C

753922

0.0053

Abz-KLKSSKQ-EDDnp

Homo sapiens

-

in the presence of 1.4 M sodium citrate, in 50 mM Tris, 1 mM EDTA, pH 7.5, at 37°C

717291

0.031

Abz-KLKSSKQ-EDDnp

Homo sapiens

-

in the presence of 0.0005 mM heparin, in 50 mM Tris, 1 mM EDTA, pH 7.5, at 37°C

717291

0.0012

Abz-KLRSSKQ-EDDnp

Homo sapiens

-

in the presence of 1.4 M sodium citrate, in 50 mM Tris, 1 mM EDTA, pH 7.5, at 37°C

717291

0.0022

Abz-KLRSSKQ-EDDnp

Homo sapiens

-

in the presence of 0.0005 mM heparin, in 50 mM Tris, 1 mM EDTA, pH 7.5, at 37°C

717291