3.4.21.119: kallikrein 13

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For detailed information about kallikrein 13, go to the full flat file.

Reaction

Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin =

Synonyms

GK-13, glandular kallikrein 13, glandular kallikrein K13, hK13, K13, kallikrein-related peptidase 13, KLK13, MGK-13, mK13, More, PRECE, prorenin converting enzyme, prorenin-converting enzyme, S01.306, tissue kallikrein

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.119 kallikrein 13

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Results	in table
5	Activating Compound
2	AA Sequence
11	Application
2	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
98	Disease/ Diagnostics
3	Expression
4	General Information
1	General Stability
2	IC50 Value
12	Inhibitors
8	kcat/KM [mM/s]
8	KM Value [mM]
6	Localization
1	Metals/Ions
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
23	Organism
5	pH Optimum
1	pI Value
2	Posttranslational Modification
1	Protein Variants
5	Purification (Commentary)
7	Reaction
1	Reaction Type
23	Reference
79	Source Tissue
1	Specific Activity [micromol/min/mg]
49	Substrates and Products (Substrate)
7	Subunits
28	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.21.119 - kallikrein 13

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in a baculovirus/insect cell line system

Homo sapiens

-

717291

expression in Pichia pastoris

Homo sapiens

-

647372

gene KLK-L4, DNA sequence determination and analysis, gene mapps to chromosome 19q13.3-q13.4, tissue expression analysis

Homo sapiens

Q9UKR3

647373

gene KLK13, encoded on chromosome 19q13.4, quantitative real-time PCR expression analysis

Homo sapiens

Q9UKR3

732966

gene KLK13, quantitative real-time PCR expression anaysis

Homo sapiens

Q9UKR3

732961

the enzyme is encoded on chromosome 19q13.4

Homo sapiens

Q9UKR3

732498