3.4.19.12: ubiquitinyl hydrolase 1
This is an abbreviated version!
For detailed information about ubiquitinyl hydrolase 1, go to the full flat file.
Word Map on EC 3.4.19.12
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3.4.19.12
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nerve
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proteasome
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neurodegenerative
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fiber
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innervation
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deubiquitinase
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polyglutamine
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ataxia
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parkinsonism
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spinocerebellar
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ubiquitin-proteasome
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polyubiquitinated
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glial
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sars-cov-2
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coronavirus
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covid-19
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calcitonin
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neurofilament
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fibrillary
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neuropeptide
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neuron-specific
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traumatic
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gene-related
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cyld
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parkin
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polyq
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synaptophysin
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ubiquitin-like
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polyproteins
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usp7
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ubiquitin-dependent
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alpha-synuclein
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deubiquitylating
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npy
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myenteric
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3clpro
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monoubiquitination
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nedd8
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cd45ro
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isg15
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intraepidermal
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k48-linked
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spermatogonial
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mono-ubiquitinated
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ubiquitin-binding
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3c-like
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mers-cov
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medicine
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isopeptide
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degradation
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synthesis
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diagnostics
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anti-sars-cov-2
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molecular biology
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analysis
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concussion
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pharmacology
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drug development
- 3.4.19.12
- nerve
- proteasome
- neurodegenerative
- fiber
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innervation
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deubiquitinase
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polyglutamine
- ataxia
- parkinsonism
- spinocerebellar
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ubiquitin-proteasome
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polyubiquitinated
- glial
- sars-cov-2
- coronavirus
- covid-19
- calcitonin
- neurofilament
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fibrillary
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neuropeptide
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neuron-specific
-
traumatic
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gene-related
- cyld
- parkin
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polyq
-
synaptophysin
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ubiquitin-like
- polyproteins
- usp7
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ubiquitin-dependent
- alpha-synuclein
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deubiquitylating
- npy
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myenteric
- 3clpro
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monoubiquitination
- nedd8
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cd45ro
- isg15
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intraepidermal
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k48-linked
- spermatogonial
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mono-ubiquitinated
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ubiquitin-binding
-
3c-like
- mers-cov
- medicine
-
isopeptide
- degradation
- synthesis
- diagnostics
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anti-sars-cov-2
- molecular biology
- analysis
- concussion
- pharmacology
- drug development
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) =
Synonyms
A20, AD-019, AMSH, associated molecule with the SH3-domain of STAM, AT-3, ataxin-3, BAP1, BPLF1, BRCA1-associated protein-1, C-terminal hydrolases UCHL3, C-terminal ubiquitin hydrolase, Cezanne, CGI-70, CYLD, de-ubiquitinating enzyme, deubiquinating isopeptidase T, deubiquitinating enzyme, Doa4, Doa4 ubiquitin hydrolase, Doa4p ubiquitin isopeptidase, DUB, dUCH, EC 3.1.2.15, esterase, ubiquitin thiol-, hydrolase, ubiquitin carboxyl-terminal, hydrolase, ubiquitin carboxyl-terminal (Aplysia californica gene Ap-uch), Iso-T, isopeptidase, isopeptidase T, More, Neuron cytoplasmic protein 9.5, neuronal-specific protein gene product 9.5, OsUCH1, OsUCH2, OsUCH3, OsUCH4, OsUCH5, OTU-1, OTUB1, OTUB2, Otubain-1, Otubain-2, ovarian tumour 1, PA-700 associated isopeptidase, papain-like protease, PGP 9.5, PGP 9.5/UCHL1, PGP9.5, PGP9.5.1, PLP2, PLpro, Ub isopeptidase, ubiquitin C terminal hydrolase 1, ubiquitin C-terminal hydrolase, ubiquitin C-terminal hydrolase (Aplysia californica gene Ap-uch), ubiquitin C-terminal hydrolase 1, ubiquitin C-terminal hydrolase 37, ubiquitin C-terminal hydrolase 8, ubiquitin C-terminal hydrolase isoform L3, ubiquitin C-terminal hydrolase L-1, ubiquitin C-terminal hydrolase L1, ubiquitin C-terminal hydrolase L3, Ubiquitin C-terminal hydrolase UCH37, ubiquitin C-terminal hydrolase-1, ubiquitin C-terminal hydrolase-L1, ubiquitin C-terminal hydrolase-L3, ubiquitin C-terminal hydrolase-L5, ubiquitin C-terminal hydrorase-L1, ubiquitin carboxy terminal hydrolase-L1, ubiquitin carboxy terminal hydrolase-L3, ubiquitin carboxy-terminal hydrolase, ubiquitin carboxy-terminal hydrolase 1, ubiquitin carboxy-terminal hydrolase L1, ubiquitin carboxy-terminal hydrolase-L1, ubiquitin carboxy-terminal hydrolase-L3, ubiquitin carboxyhydrolase L3, ubiquitin carboxyl terminal esterase L1, ubiquitin carboxyl terminal hydrolase 1, ubiquitin carboxyl terminal hydrolase L1, ubiquitin carboxyl terminal hydrolase-L1, ubiquitin carboxyl-terminal hydrolase, ubiquitin carboxyl-terminal hydrolase 1, ubiquitin carboxyl-terminal hydrolase 44, ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin carboxyl-terminal hydrolase L-1, ubiquitin carboxyl-terminal hydrolase L1, ubiquitin carboxyl-terminal hydrolase l3, ubiquitin carboxyl-terminal hydrolase L5, ubiquitin carboxyl-terminal hydrolase-L1, ubiquitin carboxyl-terminal hydrolase-L5, ubiquitin carboxyterminal hydrolase L1, ubiquitin carboxyterminal hydrolase L3, ubiquitin carboxyterminal hydrolase-L1, ubiquitin hydrolase, ubiquitin hydrolase Uch-L1, ubiquitin hydrolase UCH-L3, ubiquitin isopeptidase, Ubiquitin thiolesterase, Ubiquitin thiolesterase L1, Ubiquitin thiolesterase L3, Ubiquitin thiolesterase L4, Ubiquitin thiolesterase L5, ubiquitin-C-terminal hydrolase L1, ubiquitin-carboxyl-terminal hydrolase PGP-9.5, ubiquitin-specific protease 44, UBPY, UCH, UCH L-1, UCH L1, UCH-1, UCH-8, UCH-L1, UCH-L2, UCH-L3, UCH-L4, UCH-L5, UCH37, UCH54, UCHL-1, UCHL-3, UCHL1, UCHL1/PGP 9.5, UCHL2, Uchl3, UCHL5, UCHL5N240, USP19, USP22, USP44, yeast ubiquitin hydrolase, YUH, YUH1
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3.4.19.12 ubiquitinyl hydrolase 1Advanced search results
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
vascular smooth muscle cells. UCH-L1 is up-regulated in injured arteries
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mRNA and protein expression, expressed in endothelial cells in atherosclerotic lesions from human carotid arteries
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UCH-L1 present in the outer layer cells of the trophectoderm. UCH-L3 present in the inner cells
the median concentration of UCHL1 in the blood plasma of boys with cryptorchidism, is 5folds higher than in boys with inguinal hernia, whose testicles are located in the scrotum. Significant difference between UCHL1 levels in boys with cryptorchidism up to 2 years old, and above 2 years old. Older boys, whose testicles since birth are located in the inguinal pouch or in the abdominal cavity, have higher concentration of UCHL1 in their blood plasma, than boys from younger group
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UCHL3 and UCH37 are upregulated in the majority of tumor tissues compared to the adjacent normal tissues. UCH-L1 activity is lower in a significant proportion of the tumors but to a less extent in advanced tumors
prefrontal. UCH L1 is 1.1-1.2fold decreased in alcoholics
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in accordance with the relatively low UCH-L1 activity in tumor biopsies, UCH-L1 is detected only in one out of eight cervical carcinoma lines
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level of UCH-L3 decreases with age, while the level of UCH-L1 increases with age in wild-type mice
isoform UCH-L1 does not partition to the membrane in the cultured cell lines tested
UCHL1 expression is low, which is well correlated with its promoter methylation status
UCHL1 expression is low, which is well correlated with its promoter methylation status
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a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview
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only UCH-L3 is clearly identified in primary keratinocytes. UCH-L1 and UCH-L3 activity is upregulated following HPV E6/E7 immortalization of keratinocytes
present in cancerous cells originating from tissues that do not normally express UCH-L1, including pancreatic cancer, colorectal cancer and invasive breast cancer
UCHL1 expression is low, which is well correlated with its promoter methylation status
CYLD is drastically upregulated during RANKL-induced differentiation of preosteoclasts
expression analysis of UCHL! in the renal cell carcinoma system, profiling, overview
de novo synthesis of UCH-L1, leading to an enhanced dissassembly of ubiquitin-protein conjugates in the rostral ventrolateral medulla, is essential to maintenance of the pro-life phase of mevinphos intoxication via prevention of cardiovascular depression, leading to neuroprotection
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a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview
level of UCH-L1 mRNA is significantly reduced in fibroblasts of patients affected with lysosomal storage disorders
UCHL1 expression is low, which is well correlated with its promoter methylation status
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UCHL3 is localized to the acrosomal surface. UCHL1 is absent from the sperm surface
strong expression of UCHL1, no expression of UCHL3
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UCH37 activity is up-regulated in cervical carcinoma biopsies as well as cell lines, while UCH-L1 activity is lower in cervical carcinomas
additional information
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PGP 9.5 represents a ubiquitin carboxy-terminal hydrolase highly, localized in nervous tissue
frontal cortex of healthy, Alzheimer's disease, and Parkinson's disease brains, 3 isozymes of UCH-L1, UCH-L1 is down-regulated in Alzheimer's diesease and Parkinson's disease brains
oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases
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highly expressed. UCH-L1 expression and protein level are downregulated in the brain of patients with Alzheimer´s disease
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cortex, UCH-L1M omprises about 30% of total UCH-L1 in diseased and normal human brain
ubiquitin C-terminal hydrolase L1 is an extremely abundant protein in the brain. It is estimated to make up 1-5% of total neuronal protein
embryonic, UCH-L1 expression in the ventricular zone changes during neurogenesis and gliogenesis, high expression level in cortical plate and ventricular zone, overview
embryo, expression pattern in the ventricular zone changes between embryonic day 14 and 16, which corresponds to the transition from neurogenesis to gliogenesis. At embryonic day 14, UCH-L1 is highly expressed in the ventricular zone, where neurogenesis actively occurs, whereas its expression is prominent in the cortical plate at embroynic day 16. UCH-L1 is very weakly detected in the ventricular zone at embryonic day 16, which corresponds to the start of gliogenesis. UCH-L1 spatially mediates and enhances neurogenesis in the embryonic brain by regulating progenitor cell morphology
gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
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reduced levels of UCH-L1 mRNA (30%) and protein in a mouse model of Sandhoff disease as compared with their wild-type siblings
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in mouse brain regions, e.g. cortex, hippocampus, striatum, and midbrain, both UCH-L1M and UCH-L1S occur in varying relative amounts
ubiquitin C-terminal hydrolase L1 is an extremely abundant protein in the brain. It is estimated to make up 1-5% of total neuronal protein
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ubiquitin C-terminal hydrolase is localized especially on the olfactory organ including the olfactory bulb and olfactory epithelium in olfactory rosetta, suggesting the involvement of the protein in chemoreceptive function
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mRNA expression levels in normal breast tissue are not significantly different between premenopausal and postmenopausal women for both UCH-L1 and UCH-L3
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UCH-L3 mRNA level is significantly upregulated and UHCL1 mRNA level also show a non-significant increase in breast cancer tissue compared to adjacent normal breast tissue. Both UCH-L1 and UCH-L3 mRNA levels are significantly higher in high histological grade tumors than in low histological grade tumors. UCH-L1 mRNA level in tumors is approximately 10 times higher than that of UCH-L3
present in cancerous cells originating from tissues that do not normally express UCH-L1, including pancreatic cancer, colorectal cancer and invasive breast cancer
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down-regulation of UCHL-1 mRNA and protein in dementia with Lewy bodies, either in pure forms not associated with Alzheimer disease, and in common forms, with accompanying Alzheimer disease changes, but not in Parkinson disease. UCHL-3 expression reduced in Parkinson disease and dementia with Lewy bodies
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UCH-L1 levels are specifically increased in cerebrospinal fluid in case of traumatic brain damage, quantitative determination in different samples, overview
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UCHL1 content determination in benign and malign samples, overview
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UCH-L1 is significantly elevated in cerebrospinal fluid following controlled cortical impact and middle cerebral artery occlusion, as a model of ischemic stroke, in rats, overview
present in cancerous cells originating from tissues that do not normally express UCH-L1, including pancreatic cancer, colorectal cancer and invasive breast cancer
spatiotemporal expression of gene uch-L1 mRNA during embryo development
at 6.5 day of gestation of PGP9.5 is detected at various levels in embryonic ectoderm cells. At 10.5 and 14 day of gestation PGP9.5 is expressed at moderate to strong levels in neurons
brain, expression pattern in the ventricular zone changes between embryonic day 14 and 16, which corresponds to the transition from neurogenesis to gliogenesis. At embryonic day 14, UCH-L1 is highly expressed in the ventricular zone, where neurogenesis actively occurs, whereas its expression is prominent in the cortical plate at embroynic day 16. UCH-L1 is very weakly detected in the ventricular zone at embryonic day 16, which corresponds to the start of gliogenesis. UCH-L1 spatially mediates and enhances neurogenesis in the embryonic brain by regulating progenitor cell morphology
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UCH-L1 and UCH-L3 present during all of the embryonic stages. UCH-L1 is essentially constant in all cases, but the level of UCH-L3 is lower in the blastocyst stage. Developing embryos of gad and Uchl3 knockout mice are negative for UCH-L1 and UCH-L3
regiospecific expression of uchl1 and uchl3 in cauda, corpus, and caput, overview
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UCH-L3 is the predominant deubiquitinating enzyme in endosomal compartments of collecting duct epithelial cells
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parietal epithelial cells of Bowman's capsules and some tubular epithelia in the kidney
accumulated upon growth stimulation of starved human fibroblasts
the enzyme is found in tubular and parietal cells of the kidney and is expressed de novo in injured podocytes. Constitutive UCH-L1 expression in tubulointerstitial and glomerular cells
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parietal epithelial cells of Bowman's capsules and some tubular epithelia in the kidney
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healthy persons, and liver cirrhosis and HCC patients, quantitative USP44 determination, overview
the enzyme is highly expressed in idiopathic pulmonary fibrosis lungs
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UCHL-1 mRNA and protein expressions reduced in Parkinson disease
rostral ventrolateral, expression analysis of isozyme UCH-L1 during mevinphos intoxication, overview
at least two populations exist in the embryonic brain, cell culture
in cultured proliferating NPCs, UCH-L1 is coexpressed with nestin. In differentiating cells, UCH-L1 is highly co-expressed with the early neuronal marker TuJ1
isoform UCH-L1 does not partition to the membrane in the cultured cell lines tested
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high content of UCHL1. UCHL1/PGP 9.5 is a highly conserved protein present in virtually all neurones and neuroendocrine cells as a major component of soluble cytoplasmic protein
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UCHL1 is neuroendocrine cell-specific. Neuroendocrine gene expression in the large and small airway epithelium, UCHL1 is overexpressed in over 50% of lung cancers, overview
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high content of UCHL1. UCHL1/PGP 9.5 is a highly conserved protein present in virtually all neurones and neuroendocrine cells as a major component of soluble cytoplasmic protein
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high content of UCHL1. UCHL1/PGP 9.5 is a highly conserved protein present in virtually all neurones and neuroendocrine cells as a major component of soluble cytoplasmic protein
isoform UCHL1 is differently processed in neurons compared with clonal cell lines. In primary cultured neurons, a proportion of UCH-L1M does partition to the membrane, but this does not require farnesylation
beyond its expression in neurons UCH-L1 has only very limited expression
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high content of UCHL1. UCHL1/PGP 9.5 is a highly conserved protein present in virtually all neurones and neuroendocrine cells as a major component of soluble cytoplasmic protein
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high content of UCHL1, distribution in neuron types and cellular compartments, overview
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UCH-L1 is localized on the inside of the plasma membrane of dorsal root ganglion neurons
beyond its expression in neurons UCH-L1 has only very limited expression in other healthy tissues but it is highly expressed in several forms of cancer
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UCH-L1 is localized on the inside of the plasma membrane of dorsal root ganglion neurons
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high content of UCHL1, distribution in neuron types and cellular compartments, overview
down regulation of UCHL1 is detected immediately after oxygen-glucose deprivation treatment and its expression is subsequently restored and increased 6 h after oxygen-glucose deprivation treatment as well as during reoxygenation. A lower level of UCHL1 is detected only in apoptotic cells with severe loss of mitochondrial membrane potential. Down-regulation of endogenous UCHL1 by antisense cDNA in mouse N2a neuroblastoma cells increased the cells sensitivity to oxygen-glucose deprivation. This down-regulation of endogenous UCHL1 leads to the accumulation of p27, suggesting that UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions
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the olfactory receptor neurones (replaceable) appear to be strongly immunoreactive as do the principal neurones (mitral and mitral/tufted cells), while in the olfactory bulb the replaceable periglomerular and granule cells appear to be non-reactive, distribution in cellular compartments, overview
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subcortical localization of native UCHL1 in bovine oocytes during maturation. Expression of UCHL1 monomer does not change during meiotic maturation of bovine oocytes. Developmental competence is unaffected in parthenogenetic embryos that originated from UCH-L1 inhibitor treated oocytes
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UCH-L1 and UCH-L3 present in mature oocytes. Oocytes of gad and Uchl3 knockout mice ovaries are negative for UCH-L1 and UCH-L3, respectively
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expression of UCH-L1 in oocytes in prepubertal mouse ovaries, immunohistochemic analysis. Significant decrease in the follicular pool during the period of day 21 to day 28 after birth
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UCHL1 and UCHL3 are present in the oocyte throughout the oestrous cycle in wild-type mice, but appropriately immunoreactivity for UCHL1 is absent from the gad mouse and UCHL3 immunoreactivity is absent from the UCHL3 knock-out mouse, overview
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expression of UCH-L1 in oocytes in prepubertal mouse ovaries, immunohistochemic analysis. Significant decrease in the follicular pool during the period of day 21 to day 28 after birth
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UCHL1 present in the cortex, UCHL3 is primarly associated with the meiotic spindle of metaphase II ova
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strong cytoplasmic staining of ova in primordial and developing follicles with moderate staining of the theca externa and the corpus luteum
expression of both mRNA and protein mainly in the developing ovary and slightly in the mature ovary
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UCH-L1 and UCH-L3 are expressed in ovaries during proestrus, estrus, metestrus, and diestrus. Both proteins are present at all estrous cycle stages in wild-type mice. UCH-L1 is absent from gad ovaries and UCH-L3 from Uchl3 knockout ovaries
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ubiquitin C-terminal hydrolase localizes especially in pre-vitellogenic oocytes, suggesting that the enzyme activity could be important in oocyte growth
during the intersex stage, both mRNA and protein is expressed in the male gonad epithelium and degraded ovary
decidua basalis, the amount of UCH-L1 increases during pregnancy progression
UCH-L1 is necessary for placental and fetal development in primate placenta
at 6.5 day of gestation of PGP9.5 is detected at various levels in decidual and primary trophoblast giant cells in the placenta. At 10.5 and 14 day of gestation PGP9.5 is expressed at moderate to strong levels in neurons. At 10.5 and 14 day of gestation PGP9.5 is expressed rarely
expresses UCH-L1 and expression correlates with the differentiation status. In the cortex of normal biopsies, UCH-L1 is predominantly expressed in distal tubules, macula densa, and nerve fibres. A subset of human glomerulopathies associated with podocyte foot process effacement (membranous nephropathy, SLE class V, FSGS) de novo express UCH-L1 in podocyte cell bodies, nuclei, and processes
the enzyme is found in tubular and parietal cells of the kidney and is expressed de novo in injured podocytes
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cell culture, expression of UCH-L1 and the regulation of this expression in podocytes, overview
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UCHL1/PGP 9.5, photoreceptor cells, bipolar cells, and amacrine cells are devoid of staining while the dendrites and axons of both the horizontal cells and the ganglion cells stain strongly
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photoreceptor cells, bipolar cells, and amacrine cells are devoid of staining while the dendrites and axons of both the horizontal cells and the ganglion cells stain strongly
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localization of UCH-L3 in the wild-type retina is altered with age. UCH-L3 is enriched in the photoreceptor inner segment that contains abundant mitochondria. UCH-L1 is expressed in both genotypes in the inner retina, which consists of the inner nuclear layer, inner plexiform layer, and ganglion cell layer
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UCHL1/PGP 9.5, photoreceptor cells, bipolar cells, and amacrine cells are devoid of staining while the dendrites and axons of both the horizontal cells and the ganglion cells stain strongly
UCH-L1 may act during mitotic proliferation of spermatogonial stem cells
UCH-L3 may function in the meiotic differentiation of spermatocytes into spermatids
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UCHL3 mainly localized to the round spermatids (acrosomal cap) and elongating spermatids (caudal manchette and acrosome)
UCH-L3 may function in the meiotic differentiation of spermatocytes into spermatids
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spermatogonia in humans can be subdivided into three types, overview
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spermatogonia in monkeys can be subdivided into three types, overview
UCH-L1 may act during mitotic proliferation of spermatogonial stem cells
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expression level of UCH-L1, high or low, is associated with spermatogonial stem cell self-renewal and differentiation, overview
UCHL1 is expressed in defective spermatozoa but not in normal spermatozoa
specific carbonyl level of UCH-L1 is significantly increased in spinal cord of G93A-SOD1 transgenic mice compared to that of nontransgenic mice
absence of UCH-L1 causes resistance to cryptorchid-induced testicular germ cell apoptosis. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism
absence of UCH-L3 promotes germ cell apoptosis after cryptorchid injury. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism
mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
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UCH-L1 is exclusively expressed in spermatogonia among male germ cells. In the adult testis, UCH-L1, high or low, is expressed only in a single layer of spermatogonia at the basement membrane
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mRNA and protein expression, expressed in vascular smooth muscle cells in atherosclerotic lesions from human carotid arteries
additional information
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tissue distribution and immunohistochemic analysis, overview
additional information
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tissue-specific regulation of uhc-L1 gene expression, analysis, overview
additional information
tissue-specific regulation of uhc-L1 gene expression, analysis, overview
additional information
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the human papilloma virus-negative C33A cell line is the only cell line lacking detectable UCH-L3 activity
additional information
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UCHL1 is consistently up-regulated in airway epithelium of smokers compared with nonsmokers. UCHL1 expression is evident only in neuroendocrine cells of the airway epithelium in nonsmokers, whereas it is expressed in neuroendocrine cells and in ciliated epithelial cells in smokers
additional information
UCHL1 is downregulated in the frontal cortex of frontotemporal dementia and parkinsonism linked to chromosome 17
additional information
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UCHL1 is downregulated in the frontal cortex of frontotemporal dementia and parkinsonism linked to chromosome 17
additional information
normal kidneys express no UCH-L1 and little ubiquitin. Decrease of expression with differentiation. Minimal change glomerulonephritis demonstrates minimal UCH-L1 and ubiquitin expression with intact alpha-actinin-4 but internalized nephrin. Glomerular kidney diseases typically not associated with foot process effacement (SLE class IV, ANCA+ necrotizing GN, amyloidosis, IgA nephritis) express intermediate to no UCH-L1 and ubiquitin
additional information
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normal kidneys express no UCH-L1 and little ubiquitin. Decrease of expression with differentiation. Minimal change glomerulonephritis demonstrates minimal UCH-L1 and ubiquitin expression with intact alpha-actinin-4 but internalized nephrin. Glomerular kidney diseases typically not associated with foot process effacement (SLE class IV, ANCA+ necrotizing GN, amyloidosis, IgA nephritis) express intermediate to no UCH-L1 and ubiquitin
additional information
present in HuH-4 cells. Cancer cell lines HCT-116, EC-109, Hep-3B, HuH-1, HuH-6, Mahlavu, SNU-387 and SNU-449 have silenced UCHL1, which is well correlated with its promoter methylation status
additional information
UCH-L1 is highly expressed in H157 cells, having high invasive potential. In Akt-negative mutants, overexpression of UCH-L1 does not affect the invasion and migration capability of H157 cells
additional information
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the deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1, is highly expressed in cystic fibrosis airway epithelial cells in vitro and in vivo
additional information
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UCH-L1 is present in neurofibrillary tangles or Lewy bodies
additional information
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UCH-L1 levels are high in various types of malignancies: acute lymphoblastic leukemia, non-small cell lung cancer, neuroblastoma, pancreatic, prostate, medullary thyroid, esophageal, colorectal and renal carcinomas
additional information
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UCHL1/PGP 9.5 is present prominently in brain, in addition to its neuronal localization, UCHL1/PGP 9.5 is also present in cells of the diffuse neuroendocrine system, traces of the protein are also seen in large intestine, kidney, ovary, and testis. Tissue distribution and immunohistochemic analysis, overview. Enzyme activity in the diffuse neuroendocrine system, e.g. in gastroenteropancreatic system, prostate, pulmonary neuroendocrine system, and cerebral cortex, detailed overview
additional information
UCHL5 is constitutively expressed in several tissues, expression analysis, overview
additional information
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UCHL5 is constitutively expressed in several tissues, expression analysis, overview
additional information
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UCHL5 is constitutively expressed in several tissues, expression analysis, overview
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additional information
Uch-L1 is upregulated during gonadal transformation, especially from the beginning of the intersex stage onwards
additional information
no expression in heart, liver, kidney, or spleen. Uch-L1 is upregulated during gonadal transformation from female to male, overview
additional information
isozyme L3 is universally expressed in all tissues
additional information
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expression pattern of UCH isozymes in Sertoli cells, spermatids, spermatocytes, and spermatogonia, overview
additional information
expression pattern of UCH isozymes in Sertoli cells, spermatids, spermatocytes, and spermatogonia, overview
additional information
expression pattern of UCH isozymes in Sertoli cells, spermatids, spermatocytes, and spermatogonia, overview
additional information
quantitative testicular expression analysis of UCHL1
additional information
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absence of UCHL1 in the gracile axonal dystrophy mouse, which results in neurodegeneration
additional information
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UCH-L1 is upregulated and more abundantly expressed in germ line stem cells than in embryonic stem cells
additional information
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increased expression and activity of UCH L1 in EBV-immortalized cell lines
additional information
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tissue distribution and immunohistochemic analysis, overview
additional information
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UCH-L1 is exclusively expressed in brain and testis
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additional information
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UCH-L1 is upregulated and more abundantly expressed in germ line stem cells than in embryonic stem cells
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additional information
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tissue distribution and immunohistochemic analysis, overview
additional information
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UCH-L1 expression in podocytes is significantly higher in acute proliferative glomerulonephritis, lupus nephritis, membranous glomerulonephritis, and IgA nephropathy than that in focal segmental glomerulosclerosis, minimal change disease, minor abnormality and normal kidney tissues, overview
additional information
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in pigs, gonocytes and spermatogonia expressing UCH-L1 include the population expressing PLZF, a known determinant of undifferentiated spermatogonial stem cells, asymmetric segregation of UCH-L1 and PLZF in spermatogonia in vivo and in vitro, overview
