3.4.19.12: ubiquitinyl hydrolase 1

This is an abbreviated version, for detailed information about ubiquitinyl hydrolase 1, go to the full flat file.

Reaction

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) =

Synonyms

A20, AD-019, AMSH, associated molecule with the SH3-domain of STAM, AT-3, ataxin-3, BAP1, BPLF1, BRCA1-associated protein-1, C-terminal hydrolases UCHL3, C-terminal ubiquitin hydrolase, Cezanne, CGI-70, CYLD, de-ubiquitinating enzyme, deubiquinating isopeptidase T, deubiquitinating enzyme, Doa4, Doa4 ubiquitin hydrolase, Doa4p ubiquitin isopeptidase, DUB, dUCH, esterase, ubiquitin thiol-, hydrolase, ubiquitin carboxyl-terminal, hydrolase, ubiquitin carboxyl-terminal (Aplysia californica gene Ap-uch), Iso-T, isopeptidase, isopeptidase T, More, Neuron cytoplasmic protein 9.5, neuronal-specific protein gene product 9.5, OTU-1, ovarian tumour 1, PA-700 associated isopeptidase, papain-like protease, PGP 9.5, PGP 9.5/UCHL1, PGP9.5, PGP9.5.1, PLpro, Ub isopeptidase, ubiquitin C terminal hydrolase 1, ubiquitin C-terminal hydrolase, ubiquitin C-terminal hydrolase (Aplysia californica gene Ap-uch), ubiquitin C-terminal hydrolase 1, ubiquitin C-terminal hydrolase 37, ubiquitin C-terminal hydrolase 8, ubiquitin C-terminal hydrolase isoform L3, ubiquitin C-terminal hydrolase L-1, ubiquitin C-terminal hydrolase L1, ubiquitin C-terminal hydrolase L3, Ubiquitin C-terminal hydrolase UCH37, ubiquitin C-terminal hydrolase-1, ubiquitin C-terminal hydrolase-L1, ubiquitin C-terminal hydrolase-L3, ubiquitin C-terminal hydrolase-L5, ubiquitin C-terminal hydrorase-L1, ubiquitin carboxy terminal hydrolase-L1, ubiquitin carboxy terminal hydrolase-L3, ubiquitin carboxy-terminal hydrolase, ubiquitin carboxy-terminal hydrolase 1, ubiquitin carboxy-terminal hydrolase L1, ubiquitin carboxy-terminal hydrolase-L1, ubiquitin carboxy-terminal hydrolase-L3, ubiquitin carboxyhydrolase L3, ubiquitin carboxyl terminal esterase L1, ubiquitin carboxyl terminal hydrolase 1, ubiquitin carboxyl terminal hydrolase L1, ubiquitin carboxyl-terminal hydrolase, ubiquitin carboxyl-terminal hydrolase 1, ubiquitin carboxyl-terminal hydrolase 44, ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin carboxyl-terminal hydrolase L-1, ubiquitin carboxyl-terminal hydrolase L1, ubiquitin carboxyl-terminal hydrolase l3, ubiquitin carboxyl-terminal hydrolase L5, ubiquitin carboxyl-terminal hydrolase-L1, ubiquitin carboxyterminal hydrolase L1, ubiquitin carboxyterminal hydrolase L3, ubiquitin carboxyterminal hydrolase-L1, ubiquitin hydrolase, ubiquitin hydrolase Uch-L1, ubiquitin hydrolase UCH-L3, ubiquitin isopeptidase, Ubiquitin thiolesterase, Ubiquitin thiolesterase L1, Ubiquitin thiolesterase L3, Ubiquitin thiolesterase L4, Ubiquitin thiolesterase L5, ubiquitin-C-terminal hydrolase L1, ubiquitin-carboxyl-terminal hydrolase PGP-9.5, ubiquitin-specific protease 44, UBPY, UCH, UCH L-1, UCH L1, UCH-1, UCH-8, UCH-L1, UCH-L2, UCH-L3, UCH-L4, UCH-L5, UCH37, UCH54, UCHL-1, UCHL-3, UCHL1, UCHL1/PGP 9.5, UCHL2, Uchl3, UCHL5, UCHL5N240, USP19, USP22, USP44, yeast ubiquitin hydrolase, YUH, YUH1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.12 ubiquitinyl hydrolase 1

Source Tissue

Source Tissue on EC 3.4.19.12 - ubiquitinyl hydrolase 1

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
vascular smooth muscle cells. UCH-L1 is up-regulated in injured arteries
Manually annotated by BRENDA team
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mRNA and protein expression, expressed in endothelial cells in atherosclerotic lesions from human carotid arteries
Manually annotated by BRENDA team
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mRNA and protein expression
Manually annotated by BRENDA team
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UCH-L1 present in the outer layer cells of the trophectoderm. UCH-L3 present in the inner cells
Manually annotated by BRENDA team
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UCH-L3 mRNA level is significantly upregulated and UHCL1 mRNA level also show a non-significant increase in breast cancer tissue compared to adjacent normal breast tissue. Both UCH-L1 and UCH-L3 mRNA levels are significantly higher in high histological grade tumors than in low histological grade tumors. UCH-L1 mRNA level in tumors is approximately 10 times higher than that of UCH-L3
Manually annotated by BRENDA team
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UCH-L1 is highly expressed
Manually annotated by BRENDA team
human cervical carcinoma cell line
Manually annotated by BRENDA team
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high expression level of UCH-L1 in caput epididymis; high expression of UCH-L1
Manually annotated by BRENDA team
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UCHL3 and UCH37 are upregulated in the majority of tumor tissues compared to the adjacent normal tissues. UCH-L1 activity is lower in a significant proportion of the tumors but to a less extent in advanced tumors
Manually annotated by BRENDA team
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; down-regulation of UCHL-1 mRNA and protein in dementia with Lewy bodies, either in pure forms not associated with Alzheimer disease, and in common forms, with accompanying Alzheimer disease changes, but not in Parkinson disease. UCHL-3 expression reduced in Parkinson disease and dementia with Lewy bodies
Manually annotated by BRENDA team
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prefrontal. UCH L1 is 1.1-1.2fold decreased in alcoholics
Manually annotated by BRENDA team
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in accordance with the relatively low UCH-L1 activity in tumor biopsies, UCH-L1 is detected only in one out of eight cervical carcinoma lines
Manually annotated by BRENDA team
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lymph node metastasis, increased expression
Manually annotated by BRENDA team
; of chorionic plate and villi
Manually annotated by BRENDA team
; of decidua basalis
Manually annotated by BRENDA team
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chinese hamster cell line DON
Manually annotated by BRENDA team
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level of UCH-L3 decreases with age, while the level of UCH-L1 increases with age in wild-type mice
Manually annotated by BRENDA team
in male gonad epithelium
Manually annotated by BRENDA team
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non-small cell lung cancer cell line
Manually annotated by BRENDA team
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isoform UCH-L1 does not partition to the membrane in the cultured cell lines tested
Manually annotated by BRENDA team
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UCHL1 expression is low, which is well correlated with its promoter methylation status
Manually annotated by BRENDA team
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UCHL1 expression is low, which is well correlated with its promoter methylation status
Manually annotated by BRENDA team
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lateral
Manually annotated by BRENDA team
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a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview
Manually annotated by BRENDA team
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only UCH-L3 is clearly identified in primary keratinocytes. UCH-L1 and UCH-L3 activity is upregulated following HPV E6/E7 immortalization of keratinocytes
Manually annotated by BRENDA team
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different cell lines
Manually annotated by BRENDA team
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a B lymphoblastoid cell line
Manually annotated by BRENDA team
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present in patients with sporadic Parkinson´s disease
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
expression level of CYLD is extremely low
Manually annotated by BRENDA team
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MES13 cell line
Manually annotated by BRENDA team
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lung cancer cell line; non-small cell lung cancer cell line
Manually annotated by BRENDA team
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at least two populations exist in the embryonic brain, cell culture; in cultured proliferating NPCs, UCH-L1 is coexpressed with nestin. In differentiating cells, UCH-L1 is highly co-expressed with the early neuronal marker TuJ1
Manually annotated by BRENDA team
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; down regulation of UCHL1 is detected immediately after oxygen-glucose deprivation treatment and its expression is subsequently restored and increased 6 h after oxygen-glucose deprivation treatment as well as during reoxygenation. A lower level of UCHL1 is detected only in apoptotic cells with severe loss of mitochondrial membrane potential. Down-regulation of endogenous UCHL1 by antisense cDNA in mouse N2a neuroblastoma cells increased the cell’s sensitivity to oxygen-glucose deprivation. This down-regulation of endogenous UCHL1 leads to the accumulation of p27, suggesting that UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions
Manually annotated by BRENDA team
dominant expression; during the intersex stage, both mRNA and protein is expressed in the male gonad epithelium and degraded ovary
Manually annotated by BRENDA team
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including sensory and motor nerves
Manually annotated by BRENDA team
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UCHL1 expression is low, which is well correlated with its promoter methylation status
Manually annotated by BRENDA team
CYLD is drastically upregulated during RANKL-induced differentiation of preosteoclasts
Manually annotated by BRENDA team
expression analysis of UCHL! in the renal cell carcinoma system, profiling, overview
Manually annotated by BRENDA team
de novo synthesis of UCH-L1, leading to an enhanced dissassembly of ubiquitin-protein conjugates in the rostral ventrolateral medulla, is essential to maintenance of the pro-life phase of mevinphos intoxication via prevention of cardiovascular depression, leading to neuroprotection
Manually annotated by BRENDA team
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human prostate cell line
Manually annotated by BRENDA team
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a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview
Manually annotated by BRENDA team
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a neuroblastoma cell line
Manually annotated by BRENDA team
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level of UCH-L1 mRNA is significantly reduced in fibroblasts of patients affected with lysosomal storage disorders
Manually annotated by BRENDA team
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cholinergic neuronal cell line
Manually annotated by BRENDA team
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UCHL1 expression is low, which is well correlated with its promoter methylation status
Manually annotated by BRENDA team
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UCHL3 is localized to the acrosomal surface. UCHL1 is absent from the sperm surface
Manually annotated by BRENDA team
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UCHL-1 protein reduced in cases with Lewy body pathology
Manually annotated by BRENDA team
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strong expression of UCHL1, no expression of UCHL3
Manually annotated by BRENDA team
human osteosarcoma cell line
Manually annotated by BRENDA team
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UCH37 activity is up-regulated in cervical carcinoma biopsies as well as cell lines, while UCH-L1 activity is lower in cervical carcinomas
Manually annotated by BRENDA team
human fibroblast cell line
Manually annotated by BRENDA team
additional information