Literature summary for 3.4.19.12 extracted from

Iizuka, N.; Okamoto, K.; Matsushita, R.; Kimura, M.; Nagai, K.; Arito, M.; Kurokawa, M.S.; Masuko, K.; Suematsu, N.; Hirohata, S.; Kato, T.
Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement (2010), Lupus, 19, 717-726.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
central nervous system	-	Homo sapiens	-
neuroblastoma cell	-	Homo sapiens	-
neuron	UCH-L1 is abundantly expressed in neuronal cell	Homo sapiens	-
SK-N-MC cell	a neuroblastoma cell line	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
More	UCH-L1 is a member of the ubiquitin C-terminal hydrolases, UCH	Homo sapiens
UCH-L1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	increased oxidative carbonyl modification of UCH-L1 causes dysfunction of UCH-L1 and finally induces neuron death	Homo sapiens
additional information	autoantigenicity of UCH-L1: UCH-L1 is an antigen for autoantibodies in CNS-Lupus, systemic lupus erythematosus manifested in central nervous system, an autoimmune disease, overview	Homo sapiens

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Release 2023.1 (January 2023)