Literature summary for 3.4.19.12 extracted from

Meyer-Schwesinger, C.; Meyer, T.N.; Muenster, S.; Klug, P.; Saleem, M.; Helmchen, U.; Stahl, R.A.
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies (2009), J. Pathol., 217, 452-464.

Search for more literature for 3.4.19.12

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	UCH-L1 expression correlates with podocyte ubiquitin content and internalization of the podocyte-specific proteins nephrin and alpha-actinin-4	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
LDN 57 444	UCH-L1 inhibition leads to a time and concentration-dependent formation of membrane protrusions, accompanied by redistribution of alpha-actinin-4 to the membrane. Expression level of alpha-actinin-4 remains stable, whereas the beta-catenin content increases. Inhibition of UCH-L1 does not induce apoptosis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell membrane	undifferentiated podocytes exhibit strong UCH-L1 expression at the cell membrane along leading edges	Homo sapiens	-	-
cytoplasm	undifferentiated podocytes exhibit strong UCH-L1 expression in cytoplasm	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	role for UCH-L1 and ubiquitin modification in podocyte differentiation and injury	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09936	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	normal kidneys express no UCH-L1 and little ubiquitin. Decrease of expression with differentiation. Minimal change glomerulonephritis demonstrates minimal UCH-L1 and ubiquitin expression with intact alpha-actinin-4 but internalized nephrin. Glomerular kidney diseases typically not associated with foot process effacement (SLE class IV, ANCA+ necrotizing GN, amyloidosis, IgA nephritis) express intermediate to no UCH-L1 and ubiquitin	Homo sapiens	-
podocyte	expresses UCH-L1 and expression correlates with the differentiation status. In the cortex of normal biopsies, UCH-L1 is predominantly expressed in distal tubules, macula densa, and nerve fibres. A subset of human glomerulopathies associated with podocyte foot process effacement (membranous nephropathy, SLE class V, FSGS) de novo express UCH-L1 in podocyte cell bodies, nuclei, and processes	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	role for UCH-L1 and ubiquitin modification in podocyte differentiation and injury	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ubiquitin C-terminal hydrolase-L1	-	Homo sapiens
UCH-L1	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)