Cloned (Comment) | Organism |
---|---|
expression of His-tagged wild-type and mutant enzymes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
I93M | the mutation is linked to familial Parkinson's disease, the mutant dimer conformation is different from the wild-type enzyme deforming the globular form | Homo sapiens |
I93M | wild-type enzyme, mutant I93M (linked to familial Parkinson's disease) and S18Y (linked to reduced risk of Parkinson's disease) are all self-assembled dimers. The configuration of these dimers are quite different. The wild-type is a rotating ellipsoidal | Homo sapiens |
S18Y | the mutation is linked to reduced risk of Parkinson's disease, the mutant dimer conformation is different from the wild-type enzyme promoting the globularitiy | Homo sapiens |
S18Y | wild-type enzyme, mutant I93M (linked to familial Parkinson's disease) and S18Y (linked to reduced risk of Parkinson's disease) are all self-assembled dimers. The configuration of these dimers are quite different. The wild-type is a rotating ellipsoidal | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
28900 | - |
x * 28900, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | UCH-L1 is involved in Parkinson's disease | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) | UCH-L1 is a neuro-specific multifunctional enzyme, deubiquinating, ubiquitinyl ligase, and also stabilizing ubiquitin monomers, C90 is the active site residue | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UCH-L1 is involved in Parkinson's disease | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x '* 28900, SDS-PAGE | Homo sapiens |
dimer | wild-type enzyme, mutant I93M (linked to familial Parkinson's disease) and S18Y (linked to reduced risk of Parkinson's disease) are all self-assembled dimers. The configuration of these dimers are quite different. The wild-type is a rotating ellipsoidal | Homo sapiens |
More | the wild-type enzyme is a rotating ellipsoidal dimer, small-angle neutron scattering | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl-terminal hydrolase L1 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |