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Literature summary for 3.4.19.12 extracted from

  • Sun, J.; Shang, X.; Tian, Y.; Zhao, W.; He, Y.; Chen, K.; Cheng, H.; Zhou, R.
    Ubiquitin C-terminal hydrolase-L1 (Uch-L1) correlates with gonadal transformation in the rice field eel (2008), FEBS J., 275, 242-249.
    View publication on PubMed
Search for more literature for 3.4.19.12

Cloned(Commentary)

Cloned (Comment) Organism
gene uchl1, phylogenetic analysis Monopterus albus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 Western blot analysis Monopterus albus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Monopterus albus Uch-L1, via the ubiquitin-proteasome system, may play an important role not only in gametogenesis, but also in the gonadal transformation process in the rice field eel ?
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 ?

Organism

Organism UniProt Comment Textmining
Monopterus albus B5KNK6
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Monopterus albus B5KNK6 gene uchl1
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Source Tissue

Source Tissue Comment Organism Textmining
brain slight expression Monopterus albus
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brain expression of both mRNA and protein Monopterus albus
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gonad in male gonad epithelium Monopterus albus
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additional information Uch-L1 is upregulated during gonadal transformation, especially from the beginning of the intersex stage onwards Monopterus albus
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additional information no expression in heart, liver, kidney, or spleen. Uch-L1 is upregulated during gonadal transformation from female to male, overview Monopterus albus
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ovary expression of both mRNA and protein mainly in the developing ovary and slightly in the mature ovary Monopterus albus
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ovary slight expression, in degraded ovaries Monopterus albus
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ovotestis during the intersex stage, both mRNA and protein is expressed in the male gonad epithelium and degraded ovary Monopterus albus
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ovotestis dominant expression Monopterus albus
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spermatocyte
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 Monopterus albus
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spermatogonium
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 Monopterus albus
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testis expression of both mRNA and protein in developing germ cells Monopterus albus
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testis dominant expression Monopterus albus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Uch-L1, via the ubiquitin-proteasome system, may play an important role not only in gametogenesis, but also in the gonadal transformation process in the rice field eel Monopterus albus ?
-
 ?
additional information Uch-L1 binds to and interacts with monoubiqutin Monopterus albus ?
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 ?
polyubiquitin + H2O
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 Monopterus albus ubiquitin
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 ?

Subunits

Subunits Comment Organism
dimer SDS-PAGE, Uch-L1 undergoes dimerization and oligomerization in gonads, whereby the relative level of dimerization/oligomerization decreases during gonadal transformation. Rates of dimerization and oligomerization are high in ovary and lower in ovotestis, whereas monomers are mainly formed in testis Monopterus albus
dimer 2 * 26000, SDS-PAGE, rates of dimerization and oligomerization are high in ovary and lower in ovotestis, whereas monomers are mainly formed in testis. The dimerization/oligomerization level of Uch-L1 decreases during gonadal transformation from female to male. UCH-L1 structure modelling Monopterus albus
monomer 1 * 26000, SDS-PAGE, rates of dimerization and oligomerization are high in ovary and lower in ovotestis, whereas monomers are mainly formed in testis. The dimerization/oligomerization level of Uch-L1 decreases during gonadal transformation from female to male. UCH-L1 structure modelling Monopterus albus

Synonyms

Synonyms Comment Organism
More Uch-L1 is a member of the Uch family Monopterus albus
ubiquitin C-terminal hydrolase-L1
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 Monopterus albus
ubiquitin carboxyl-terminal hydrolase-L1
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 Monopterus albus
UCH-L1
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 Monopterus albus

General Information

General Information Comment Organism
physiological function Uch-L1 plays an important role in the maintenance of intracellular monoubiquitin levels by generating ubiquitin through the hydrolysis of polyubiquitinated proteins, and regulates the ubiquitin pathway. It is important in gametogenesis and gonadal transformation Monopterus albus