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3.4.17.11: glutamate carboxypeptidase

This is an abbreviated version!
For detailed information about glutamate carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.17.11

Reaction

release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups =

Synonyms

carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, CPDG2, CPG2, folate hydrolase G2, glucarpidase, glutamate carboxypeptidase, glutamyl carboxypeptidase, N-pteroyl-L-glutamate hydrolase, pteroylmonoglutamic acid hydrolase G2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.11 glutamate carboxypeptidase

Substrates Products

Substrates Products on EC 3.4.17.11 - glutamate carboxypeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2-chloroethyl)-(2-(methylsulfoyloxyethyl)amino)aminobenzyl-L-glutamic acid + H2O
(2-chloroethyl)-(2-(methylsulfoyloxyethyl)amino)aminobenzoic acid + L-glutamate
show the reaction diagram
-
a prodrug
-
-
?
(2S,2'S)-2,2'-(pentane-1,5-diylbis[oxy[(11S,11aS)-11-hydroxy-7-methoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-8,10(5H)-diyl]carbonyloxymethanediylbenzene-4,1-diylcarbamoylimino])dipentanedioic acid + 2 H2O
(11aS,11a'S)-8,8'-[pentane-1,5-diylbis(oxy)]bis(7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one) + ?
show the reaction diagram
-
-
-
-
?
(2S,2'S)-2,2'-(pentane-1,5-diylbis[oxy[(11S,11aS)-11-hydroxy-7-methoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-8,10(5H)-diyl]carbonyloxymethanediylbenzene-4,1-diyloxycarbonylimino])dipentanedioic acid + 2 H2O
3-hydroxybenzyl 4-hydroxybenzyl (11S,11aS,11'S,11a'S)-8,8'-[pentane-1,5-diylbis(oxy)]bis(11-hydroxy-7-methoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-10(5H)-carboxylate) + 2 N-carboxy-L-glutamate
show the reaction diagram
-
-
-
-
?
(4-[bis(2-bromoethyl)amino]-2,3,5-trifluorobenzoyl)-L-glutamic acid + H2O
4-[bis(2-bromoethyl)amino]-2,3,5-trifluorobenzoic acid + L-glutamate
show the reaction diagram
-
a trifluorinated prodrug
-
-
?
(4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid + H2O
4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoic acid + L-glutamate
show the reaction diagram
(4-[bis(2-chloroethyl)amino]-2,3,5-trifluorobenzoyl)-L-glutamic acid + H2O
4-[bis(2-chloroethyl)amino]-2,3,5-trifluorobenzoic acid + L-glutamate
show the reaction diagram
-
a trifluorinated prodrug
-
-
?
(4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid + H2O
4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoic acid + L-glutamate
show the reaction diagram
-
a difluorinated prodrug
-
-
?
(4-[bis(2-iodoethyl)amino]-2,3,5-trifluorobenzoyl)-L-glutamic acid + H2O
4-[bis(2-iodoethyl)amino]-2,3,5-trifluorobenzoic acid + L-glutamate
show the reaction diagram
-
a trifluorinated prodrug
-
-
?
(4-[bis(2-iodoethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid + H2O
4-[bis(2-iodoethyl)amino]-3,5-difluorobenzoic acid + L-glutamate
show the reaction diagram
(6R,S)-leucovorin + H2O
N-(6R,S)-5-formyl-5,6,7,8-tetrahydropteroic acid + L-glutamate
show the reaction diagram
2,4-dihydroxypteroyl-L-glutamic acid + H2O
2,4-dihydroxypteroate + L-Glu
show the reaction diagram
-
-
-
-
?
3,5-difluoro-4-[bis(2-iodoethyl)amino]benzoic acid + H2O
?
show the reaction diagram
-
cognate drug
-
-
?
3,5-difluoro-4-[bis(2-iodoethyl)amino]benzoyl-L-glutamic acid + H2O
?
show the reaction diagram
-
prodrug activated by CPG2
-
-
?
3,5-difluorobenzoyl-L-glutamate + H2O
3,5-difluorobenzoate + L-glutamate
show the reaction diagram
-
chemical exchange saturation transfer magnetic resonance study, i.e. CEST-MR to monitor the release of glutamate. CEST-MR affords the detection of CPG2 activity in vitro and supports the translation of CEST-MRI to assess CPG2-based gene therapy in vivo
-
?
3,5-difluorobenzoyl-L-glutamic acid + H2O
3,5-difluorobenzoic acid + L-glutamate
show the reaction diagram
-
-
-
-
?
3-fluoro-4-[bis(2-chloroethyl)amino]benzoyl-L-glutamic acid + H2O
?
show the reaction diagram
-
prodrug activated by CPG2
-
-
?
4-([bis(2-iodoethyl)amino]-phenyl)oxycarbonyl-L-glutamic acid + H2O
4-[bis(2-iodoethyl)amino]-phenylcarbonate + L-glutamate
show the reaction diagram
4-amino-N10-methylpteroylaspartic acid + H2O
4-amino-N10-methylpteroate + Asp
show the reaction diagram
-
-
-
-
?
4-aminobenzoyl-L-glutamic acid + H2O
4-aminobenzoate + glutamate
show the reaction diagram
-
-
-
-
?
4-aminobenzoyl-L-glutamic acid + H2O
4-aminobenzoate + L-glutamate
show the reaction diagram
-
-
-
?
4-aminopteroylaspartic acid + H2O
4-aminopteroate + Asp
show the reaction diagram
-
-
-
-
?
4-aminopteroylglutamic acid + H2O
4-aminopteroate + Glu
show the reaction diagram
4-[(2-chloroethyl)(2-methylsulphonyloxyethyl)amino]benzoic acid + H2O
?
show the reaction diagram
-
cognate drug
-
-
?
4-[(2-chloroethyl)-(2-methylsulphonyloxyethyl)amino]benzoyl-L-glutamic acid + H2O
?
show the reaction diagram
-
prodrug activated by CPG2
-
-
?
4-[bis(2-iodoethyl)-amino]-phenyloxycarbonyl-L-glutamic acid + H2O
?
show the reaction diagram
-
prodrug activated by CPG2
-
-
?
5-formyltetrahydrofolic acid + H2O
5-formylpteroate + Glu
show the reaction diagram
5-methyltetrahydrofolate + H2O
5-methylpteroate + Glu
show the reaction diagram
7-hydroxy-methotrexate + H2O
7-hydroxy-4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate
show the reaction diagram
-
-
-
-
?
alpha-L-glutamyl-L-glutamic acid + H2O
L-Glu + L-Glu
show the reaction diagram
-
-
-
-
?
aminopterin + H2O
?
show the reaction diagram
-
-
-
-
?
benzoyl-L-glutamic acid + H2O
benzoate + glutamate
show the reaction diagram
-
-
-
-
?
di-tert-butyl 4-[[2'-[N,N-bis(2''-chloroethyl)amino]phenyl]carbamoyloxymethyl]phenyloxycarbonyl-L-glutamic acid + H2O
?
show the reaction diagram
-
-
-
-
?
diallyl 4-[N-[4'-bis(2''-chloroethyl)aminophenyl]-N-methylcarbamoyloxymethyl]phenylcarbamoyl-L-glutamic acid + H2O
?
show the reaction diagram
-
-
-
-
?
diallyl 4-[[2'-[N,N-bis(2''-chloroethyl)amino]phenyl]carbamoyloxymethyl]phenylcarbamoyl-L-glutamic acid + H2O
?
show the reaction diagram
-
-
-
-
?
diethylstilbestrol-glutamate + H2O
diethylstilbestrol + L-glutamate
show the reaction diagram
dihydrofolic acid + H2O
dihydropteroic acid + Glu
show the reaction diagram
-
-
-
-
?
folic acid + H2O
pteroic acid + glutamic acid
show the reaction diagram
gamma-L-glutamyl-L-glutamic acid + H2O
L-Glu + L-Glu
show the reaction diagram
-
-
-
-
?
glycyl-L-glutamic acid + H2O
glycine + glutamate
show the reaction diagram
-
-
-
-
?
L-tyrosyl-L-glutamic acid + H2O
tyrosine + glutamate
show the reaction diagram
-
-
-
-
?
methotrexate + H2O
4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate
show the reaction diagram
methotrexate + H2O
4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate
show the reaction diagram
methotrexate + H2O
?
show the reaction diagram
-
substrate in activity assay
-
-
?
N-([4-[([[(11S,11aS)-11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]carbonyl]oxy)methyl]phenoxy]carbonyl)-L-glutamic acid + H2O
(11aS)-7,8-dimethoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one + ?
show the reaction diagram
-
-
-
-
?
N-([4-[([[(11S,11aS)-11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]carbonyl]oxy)methyl]phenyl]carbamoyl)-L-glutamic acid + H2O
? + L-glutamate
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-aspartic acid + H2O
benzyl carbonate + L-Asp
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-glutamic acid + H2O
benzyl carbonate + L-Glu
show the reaction diagram
-
no activity with D-glutamic acid
-
-
?
N-benzyloxycarbonyl-L-glutamine + H2O
benzyl carbonate + L-Gln
show the reaction diagram
-
-
-
-
?
pteroyl-gamma,gamma-triglutamate + H2O
?
show the reaction diagram
-
-
-
-
?
[4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid + H2O
?
show the reaction diagram
-
prodrug activated by CPG2
-
-
?
[4-[bis(2-hydroxyethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid + H2O
?
show the reaction diagram
-
prodrug activated by CPG2
-
-
?
additional information
?
-