3.4.17.11: glutamate carboxypeptidase

This is an abbreviated version!
For detailed information about glutamate carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.17.11

3.4.17.11

methotrexate

prodrugs

high-dose

antibody-directed

leucovorin

hdmtx

methotrexate-induced

gene-directed

naaladase

gdept

antibody-enzyme

medicine

anti-cea

anti-carcinoembryonic

prodrug-activating

gcpii

2-pmpa

n-acetyl-aspartyl-glutamate

dampa

drug development

diagnostics

pharmacology

Reaction

release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups =

Synonyms

carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, CPDG2, CPG2, folate hydrolase G2, glucarpidase, glutamate carboxypeptidase, glutamyl carboxypeptidase, N-pteroyl-L-glutamate hydrolase, pteroylmonoglutamic acid hydrolase G2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.17 Metallocarboxypeptidases

3.4.17.11 glutamate carboxypeptidase

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Results	in table
1463	AA Sequence
17	Application
3	CAS Registry Number
7	Cloned(Commentary)
3	Crystallization (Commentary)
273	Disease/ Diagnostics
2	General Stability
2	IC50 Value
33	Inhibitors
27	KM Value [mM]
1	Localization
15	Metals/Ions
9	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
26	Organism
20	PDB ID
10	pH Optimum
1	pH Range
1	Posttranslational Modification
11	Protein Variants
11	Purification (Commentary)
1	Reaction
3	Reaction Type
26	Reference
1	Renatured (Commentary)
10	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
98	Substrates and Products (Substrate)
5	Subunits
45	Synonyms
5	Temperature Optimum [°C]
1	Temperature Range [°C]
12	Temperature Stability [°C]
15	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.17.11 - glutamate carboxypeptidase

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(2S,2'S)-2,2'-(pentane-1,5-diylbis[oxy[(11S,11aS)-11-hydroxy-7-methoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-8,10(5H)-diyl]carbonyloxymethanediylbenzene-4,1-diylcarbamoylimino])dipentanedioic acid + 2 H2O

(11aS,11a'S)-8,8'-[pentane-1,5-diylbis(oxy)]bis(7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one) + ?

Homo sapiens

667975

3-hydroxybenzyl 4-hydroxybenzyl (11S,11aS,11'S,11a'S)-8,8'-[pentane-1,5-diylbis(oxy)]bis(11-hydroxy-7-methoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-10(5H)-carboxylate) + 2 N-carboxy-L-glutamate

Homo sapiens

667975

(4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid + H2O

4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoic acid + L-glutamate

2 entries

(4-[bis(2-iodoethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid + H2O

4-[bis(2-iodoethyl)amino]-3,5-difluorobenzoic acid + L-glutamate

2 entries

(6R,S)-leucovorin + H2O

N-(6R,S)-5-formyl-5,6,7,8-tetrahydropteroic acid + L-glutamate

Homo sapiens

inactivation of the antitumor drug

668134

4-([bis(2-iodoethyl)amino]-phenyl)oxycarbonyl-L-glutamic acid + H2O

4-[bis(2-iodoethyl)amino]-phenylcarbonate + L-glutamate

Pseudomonas aeruginosa

substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy

679268

7-hydroxy-methotrexate + H2O

7-hydroxy-4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate

Homo sapiens

668134

diethylstilbestrol-glutamate + H2O

diethylstilbestrol + L-glutamate

Pseudomonas sp.

the water soluble substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy

681100

methotrexate + H2O

4-amino-4-deoxy-N10-methylpteroic acid + L-glutamate

Homo sapiens

highly reduced clearance of the drug in enzyme-defective patients leads to severe neutropenia, mucositis, nephrotoxicity, neurotoxicity, and elevation of liver enzymes in plasma

668134

methotrexate + H2O

4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate

Pseudomonas sp.

related toxicity, overview, rapid inactivation of methotrexate by CPDG2, the product DAMPA is eliminated more raoidly than methotrexate

668101

i.e. DAMPA

N-([4-[([[(11S,11aS)-11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]carbonyl]oxy)methyl]phenoxy]carbonyl)-L-glutamic acid + H2O

(11aS)-7,8-dimethoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one + ?

Homo sapiens

667975

N-([4-[([[(11S,11aS)-11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]carbonyl]oxy)methyl]phenyl]carbamoyl)-L-glutamic acid + H2O

? + L-glutamate

Homo sapiens

667975

additional information

7 entries