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Disease on EC 3.4.17.11 - glutamate carboxypeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Acute renal failure post high dose methotrexate infusion successfully managed with high dose folinic Acid and high flux dialysis.
Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure.
Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.
Efficacy of Glucarpidase (Carboxypeptidase G2) in Patients with Acute Kidney Injury After High-Dose Methotrexate Therapy.
Fixed-Dose Glucarpidase for Toxic Methotrexate Levels and Acute Kidney Injury in Adult Lymphoma Patients: Case Series.
Recovery of methotrexate-induced anuric acute kidney injury after glucarpidase therapy.
Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients.
[Renal toxicity of high-dose methotrexate].
Autoimmune Diseases
Soluble expression, purification and functional characterisation of carboxypeptidase G2 and its individual domains.
Brain Injuries
Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury.
Breast Neoplasms
Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women.
Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect.
Carcinoma
Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
Carcinoma, Hepatocellular
Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.
Carcinoma, Non-Small-Cell Lung
DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767.
Choriocarcinoma
A cytotoxic agent can be generated selectively at cancer sites.
The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro.
The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model.
Colonic Neoplasms
Carboxypeptidase G2 and trimetrexate cause growth delay of human colonic cancer cells in vitro.
Colorectal Neoplasms
Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.
DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767.
Hepatitis C
Gateways to clinical trials.
Herpes Simplex
Prodrugs in genetic chemoradiotherapy.
Hodgkin Disease
Successful carboxypeptidase G2 rescue of a high-risk elderly Hodgkin lymphoma patient with methotrexate intoxication and renal failure.
Leukemia
Length of stay, mortality, and readmissions among Medicare cancer patients treated with glucarpidase and conventional care: a retrospective study.
Liver Neoplasms
Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis.
Lung Neoplasms
DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767.
Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization.
Lymphoma
Carboxypeptidase G2 rescue after high-dose methotrexate.
Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure.
Fixed-Dose Glucarpidase for Toxic Methotrexate Levels and Acute Kidney Injury in Adult Lymphoma Patients: Case Series.
Length of stay, mortality, and readmissions among Medicare cancer patients treated with glucarpidase and conventional care: a retrospective study.
Medulloblastoma
Comparative effects of citrovorum factor and carboxypeptidase G1 on cerebrospinal fluid-methotrexate pharmacokinetics.
Melanoma
Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
Neoplasm Metastasis
Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis.
Neoplasms
Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds.
Antibody-directed enzyme prodrug therapy (ADEPT).
Aptamers and apple pies: a mini-review of PSMA aptamers and lessons from Donald S. Coffey.
Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.
Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft.
Biphasically Modulating the Activity of Carboxypeptidase G2 with Ultrasound.
Catalytic activity of an in vivo tumor targeted anti-CEA scFv::carboxypeptidase G2 fusion protein.
Characterisation of the Carboxypeptidase G2 Catalytic Site and Design of New Inhibitors for Cancer Therapy.
Characterization of a Stable Form of Carboxypeptidase G2 (Glucarpidase), a Potential Biobetter Variant, From Acinetobacter sp. 263903-1.
Clinical applications of phage-derived sFvs and sFv fusion proteins.
Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site.
Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy.
Detection of the Prodrug-Activating Enzyme Carboxypeptidase G2 Activity with Chemical Exchange Saturation Transfer Magnetic Resonance.
Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme.
Functional overexpression and purification of a codon optimized synthetic glucarpidase (carboxypeptidase G2) in Escherichia coli.
Gateways to clinical trials.
Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy.
Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity.
In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy.
Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model.
Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue.
Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment.
Length of stay, mortality, and readmissions among Medicare cancer patients treated with glucarpidase and conventional care: a retrospective study.
Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT).
Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy.
Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2.
Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT).
Production of "biobetter" glucarpidase variants to improve drug detoxification and antibody directed enzyme prodrug therapy for cancer treatment.
Production of "biobetter" variants of glucarpidase with enhanced enzyme activity.
Recombinant anti-carcinoembryonic antigen antibodies for targeting cancer.
Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients.
Soluble expression, purification and functional characterisation of carboxypeptidase G2 and its individual domains.
Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.
Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.
Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2.
Neural Tube Defects
Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India.
Osteosarcoma
2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity.
Efficacy of Glucarpidase (Carboxypeptidase G2) in Patients with Acute Kidney Injury After High-Dose Methotrexate Therapy.
High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma.
Peripheral Nervous System Diseases
Glutamate Carboxypeptidase Inhibition Reduces the Severity of Chemotherapy-Induced Peripheral Neurotoxicity in Rat.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Delayed elimination of high-dose methotrexate and use of carboxypeptidase G2 in pediatric patients during treatment for acute lymphoblastic leukemia.
Novel risk factors for glucarpidase use in pediatric acute lymphoblastic leukemia: Hispanic ethnicity, age, and the ABCC4 gene.
Prostatic Neoplasms
68Ga/64Cu PSMA bio-distribution in prostate cancer patients: potential pitfalls for different tracers.
A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules.
Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
Aptamers and apple pies: a mini-review of PSMA aptamers and lessons from Donald S. Coffey.
Expression of prostate specific membrane antigen and three alternatively spliced variants of PSMA in prostate cancer patients.
Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer.
Pruritus
Glucarpidase to combat toxic levels of methotrexate in patients.
Renal Insufficiency
Carboxypeptidase G2 rescue in delayed methotrexate elimination in renal failure.
Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure.
Glucarpidase following high-dose methotrexate: update on development.
Interactions of carboxypeptidase G2 with 6S-leucovorin and 6R-leucovorin in vitro: implications for the application in case of methotrexate intoxications.
Successful carboxypeptidase G2 rescue in delayed methotrexate elimination due to renal failure.
Successful carboxypeptidase G2 rescue in delayed MTX-elimination due to renal failure.
Successful carboxypeptidase G2 rescue of a high-risk elderly Hodgkin lymphoma patient with methotrexate intoxication and renal failure.
[Carboxypeptidase-G2-rescue in a woman with methotrexate-induced renal failure]
Stomach Neoplasms
Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer.