Literature summary for 3.4.17.11 extracted from

Jamin, Y.; Eykyn, T.R.; Poon, E.; Springer, C.J.; Robinson, S.P.
Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance (2014), Mol. Imaging Biol., 16, 152-157.

Search for more literature for 3.4.17.11

Application

Application	Comment	Organism
medicine	glutamate chemical exchange saturation transfer magnetic resonance imaging GluCEST-MRI is an attractive method for metabolic imaging of glutamate. The change in glutamate concentration measured with GluCEST MRI could provide a noninvasive biomarker of carboxypeptidase G2 activity, in addition to acting as a surrogate for prodrug activation and the concentration of activated drug in the tumor	Pseudomonas sp.

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas sp.	P06621	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Pseudomonas sp.	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,5-difluorobenzoyl-L-glutamate + H2O	-	Pseudomonas sp.	3,5-difluorobenzoate + L-glutamate	chemical exchange saturation transfer magnetic resonance study, i.e. CEST-MR to monitor the release of glutamate. CEST-MR affords the detection of CPG2 activity in vitro and supports the translation of CEST-MRI to assess CPG2-based gene therapy in vivo	?

Synonyms

Synonyms	Comment	Organism
carboxypeptidase G2	-	Pseudomonas sp.

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Release 2023.1 (January 2023)