Literature summary for 3.4.17.11 extracted from

Mayer, A.; Francis, R.J.; Sharma, S.K.; Tolner, B.; Springer, C.J.; Martin, J.; Boxer, G.M.; Bell, J.; Green, A.J.; Hartley, J.A.; Cruickshank, C.; Wren, J.; Chester, K.A.; Begent, R.H.
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug (2006), Clin. Cancer Res., 12, 6509-6516.

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Application

Application	Comment	Organism
medicine	potential use in antibody directed enzyme prodrug therapy (ADEPT)	Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4-([bis(2-iodoethyl)amino]-phenyl)oxycarbonyl-L-glutamic acid + H2O	Pseudomonas aeruginosa	substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy	4-[bis(2-iodoethyl)amino]-phenylcarbonate + L-glutamate	-	?
additional information	Pseudomonas aeruginosa	specifically cleaves terminal glutamic acid amines	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	-	Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-([bis(2-iodoethyl)amino]-phenyl)oxycarbonyl-L-glutamic acid + H2O	-	Pseudomonas aeruginosa	4-[bis(2-iodoethyl)amino]-phenylcarbonate + L-glutamate	-	?
4-([bis(2-iodoethyl)amino]-phenyl)oxycarbonyl-L-glutamic acid + H2O	substrate can be used as a prodrug that is hydrolyzed to yield the active drug in an antibody directed enzyme prodrug therapy	Pseudomonas aeruginosa	4-[bis(2-iodoethyl)amino]-phenylcarbonate + L-glutamate	-	?
additional information	specifically cleaves terminal glutamic acid amines	Pseudomonas aeruginosa	?	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Pseudomonas aeruginosa

Synonyms

Synonyms	Comment	Organism
carboxypeptidase G2	-	Pseudomonas aeruginosa
CPG2	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)