3.4.17.11: glutamate carboxypeptidase

This is an abbreviated version!
For detailed information about glutamate carboxypeptidase, go to the full flat file.

Reaction

release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups =

Synonyms

carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, CPDG2, CPG2, folate hydrolase G2, glucarpidase, glutamate carboxypeptidase, glutamyl carboxypeptidase, N-pteroyl-L-glutamate hydrolase, pteroylmonoglutamic acid hydrolase G2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.11 glutamate carboxypeptidase

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Results	in table
1463	AA Sequence
17	Application
3	CAS Registry Number
7	Cloned(Commentary)
3	Crystallization (Commentary)
273	Disease/ Diagnostics
2	General Stability
2	IC50 Value
33	Inhibitors
27	KM Value [mM]
1	Localization
15	Metals/Ions
9	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
26	Organism
20	PDB ID
10	pH Optimum
1	pH Range
1	Posttranslational Modification
11	Protein Variants
11	Purification (Commentary)
1	Reaction
3	Reaction Type
26	Reference
1	Renatured (Commentary)
10	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
98	Substrates and Products (Substrate)
5	Subunits
45	Synonyms
5	Temperature Optimum [°C]
1	Temperature Range [°C]
12	Temperature Stability [°C]
15	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

583

(2-chloroethyl)-(2-(methylsulfoyloxyethyl)amino)aminobenzyl-L-glutamic acid

Pseudomonas sp.

-

pH 7.3, 37 °C

669785

825

(4-[bis(2-bromoethyl)amino]-2,3,5-trifluorobenzoyl)-L-glutamic acid

Pseudomonas sp.

-

pH 7.3, 37 °C

669785

827

(4-[bis(2-bromoethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid

Pseudomonas sp.

-

pH 7.3, 37 °C

669785

1150

(4-[bis(2-chloroethyl)amino]-2,3,5-trifluorobenzoyl)-L-glutamic acid

Pseudomonas sp.

-

pH 7.3, 37 °C

669785

732

(4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid

Pseudomonas sp.

-

pH 7.3, 37 °C

669785

220

(4-[bis(2-iodoethyl)amino]-2,3,5-trifluorobenzoyl)-L-glutamic acid

Pseudomonas sp.

-

pH 7.3, 37 °C

669785

1150

(4-[bis(2-iodoethyl)amino]-3,5-difluorobenzoyl)-L-glutamic acid

Pseudomonas sp.

-

pH 7.3, 37 °C

669785

5.5

diallyl 4-[N-[4'-bis(2''-chloroethyl)aminophenyl]-N-methylcarbamoyloxymethyl]phenylcarbamoyl-L-glutamic acid

Pseudomonas sp.

-

-

647250

2.9

diallyl 4-[[2'-[N,N-bis(2''-chloroethyl)amino]phenyl]carbamoyloxymethyl]phenylcarbamoyl-L-glutamic acid

Pseudomonas sp.

-

-

647250

24.83 - 27.21

methotrexate

4 entries

732

[4-[bis(2-chloroethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid

Homo sapiens

-

-

700491

747

[4-[bis(2-hydroxyethyl)amino]-3,5-difluorobenzoyl]-L-glutamic acid

Homo sapiens

-

-

700491

24.83

methotrexate

Pseudomonas sp. RS-16

P06621

pH 7.3, 37°C, wild-type enzyme

752914

26.11

methotrexate

Pseudomonas sp. RS-16

P06621

pH 7.3, 37°C, mutant enzyme I100T

752914

26.93

methotrexate

Pseudomonas sp. RS-16

P06621

pH 7.3, 37°C, mutant enzyme T329A

752914

27.21

methotrexate

Pseudomonas sp. RS-16

P06621

pH 7.3, 37°C, mutant enzyme G123S

752914