3.3.2.9: microsomal epoxide hydrolase
This is an abbreviated version!
For detailed information about microsomal epoxide hydrolase, go to the full flat file.
Word Map on EC 3.3.2.9
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3.3.2.9
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phenobarbital
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cholesterol
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phospholipid
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hepatocytes
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monooxygenase
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hydroxylase
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triglyceride
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xenobiotics
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steroid
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nadph-cytochrome
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thyroid
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isozymes
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lipoprotein
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s-transferase
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testosterone
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aniline
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benzoapyrene
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phosphatidylcholine
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glucuronidation
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3-methylcholanthrene
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bile
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drug-metabolizing
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arachidonic
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prostaglandin
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acyltransferase
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heme
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hepatotoxicity
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nadph-dependent
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cyp2e1
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gsh
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autoimmune
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apolipoprotein
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cyp1a2
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autoantibody
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biphenyls
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polycyclic
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udp-glucuronosyltransferase
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monoxide
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glucose-6-phosphatase
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tetrachloride
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polychlorinated
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thyroglobulin
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ketoconazole
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demethylase
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ccl4
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desaturation
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n-oxide
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androstenedione
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beta-hydroxysteroid
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21-hydroxylase
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synthesis
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medicine
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drug development
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analysis
- 3.3.2.9
- phenobarbital
- cholesterol
- phospholipid
- hepatocytes
- monooxygenase
- hydroxylase
- triglyceride
- xenobiotics
- steroid
-
nadph-cytochrome
- thyroid
- isozymes
- lipoprotein
- s-transferase
- testosterone
- aniline
-
benzoapyrene
- phosphatidylcholine
-
glucuronidation
- 3-methylcholanthrene
- bile
-
drug-metabolizing
-
arachidonic
- prostaglandin
- acyltransferase
- heme
-
hepatotoxicity
-
nadph-dependent
- cyp2e1
- gsh
- autoimmune
-
apolipoprotein
- cyp1a2
- autoantibody
- biphenyls
-
polycyclic
-
udp-glucuronosyltransferase
- monoxide
- glucose-6-phosphatase
-
tetrachloride
-
polychlorinated
- thyroglobulin
- ketoconazole
- demethylase
- ccl4
-
desaturation
- n-oxide
- androstenedione
-
beta-hydroxysteroid
- 21-hydroxylase
- synthesis
- medicine
- drug development
- analysis
Reaction
Synonyms
alpha,beta fold epoxide hydrolase, alpha,beta-fold type EH, E1-b', EC 3.3.2.3, EC 4.2.1.63, EC 4.2.1.64, EH1, EH2, Eha, EHb, EPHX, EPHX 1, EPHX1, EPOX, epoxide hydrolase, HYL1, JH epoxide hydrolase, JHEH, juvenile hormone epoxide hydrolase, mEH, mEH-like protein, mEH1, mEPHX, microsomal, microsomal EH, microsomal EPHX1, Microsomal epoxide hydrolase, microsomal epoxide hydrolase 1, microsomal epoxide hydrolase-like protein, microsomal xenobiotic epoxide hydrolase, More, PNSO hydrolase, SEH, styrene-epoxide hydrolase, Tcjheh-r1, Tcjheh-r3, XEHase, xenobiotic epoxide hydrolase
ECTree
3.3.2.9 microsomal epoxide hydrolaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.3.2.9 - microsomal epoxide hydrolase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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hypophysectomy induces the liver enzyme in females and males
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regulation of mEH during the menstrual cycle: during the first half mEH expression is low, increases during the second half and reaches highest levels during pregnancy, immunohistochemical analysis, overview
additional information
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mEH distribution, immunohistochemical analysis, overview. mEH immunoreactivity is present in specific neuronal populations of the hippocampus, striatum, amygdala, and cerebellum, as well as in a fraction of astrocytes
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mEH distribution, immunohistochemical analysis, overview. mEH immunoreactivity is present in specific neuronal populations of the hippocampus, striatum, amygdala, and cerebellum, as well as in a fraction of astrocytes
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glial cell culture, enzyme expression is elevated in hippocampus and associated cortex of patients with Alzheimer's disease
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208879, 208881, 208884, 208893, 208895, 208900, 208901, 208915, 660713, 663275, 663434, 697577, 700328, 708309, 732444, 732905, 736011
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both the E1 and the E1-b EPHX1 transcripts are detected at high levels in the liver although E1-b is the major hepatic transcript, accounting for about 70% of the total EPHX1 RNA expressed in this tissue
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208880, 208881, 208889, 208896, 208901, 208903, 208907, 660713, 660845, 661024, 663275, 663434, 731547
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208878, 208879, 208880, 208881, 208884, 208885, 208886, 208887, 208888, 208890, 208892, 208893, 208895, 208896, 208897, 208899, 208901, 208908, 208915, 208919, 654344, 654503, 657394, 660713, 660782, 661435, 662084, 663434, 697312, 700328
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in the rat basal lung epoxide hydrolase activity is much lower than liver
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neonatal mouse ovarian culture system. Incubation of ovaries in presence of 7,12-dimethylbenz[a]anthracene. At 1 mM 7,12-dimethylbenz[a]anthracene, follicle loss and increased microsomal epoxide hydrolase protein are measured by 6 h. mRNA encoding epoxide hydrolase markedly increases after 2 days of incubation, and this increase precedes accelerated follicle loss at 4 days
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exposure to 4-vinylcyclohexene results in increased mRNA and protein expression of microsomal epoxide hydrolase, and an inactive tetrol metabolite 4-(1,2-dihydroxy)ethyl-1,2-dihydroxycyclohexane can be formed in mouse ovarian follicles, potentially through detoxification action of mEH
using a post-natal day 4 Fischer 344 rat whole ovary culture system, inhibition of mEH using cyclohexene oxide during 4-vinylcyclohexene exposure results in a greater loss of primordial and small primary follicles relative to 4-vinylcyclohexene-treated ovaries. Also, relative to controls, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days. Inhibition of PI3K signaling increases mEH mRNA and protein expression
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post-natal day 4, both primordial and small primary follicles
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the transcript of Ephx1 increases in the oviductal epithelium at the estrus stage and in day 3 of pregnancy
additional information
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wide tissue distribution in mammalian tissue, enzyme levels vary with environmental exposure, sex, and age
additional information
gene expression of EPHX1 in most tissues and anatomical compartments, by microarray, SAGE, and RNASeq, highest EPHX1 transcript and protein levels in liver and skin, high inter-individual variation among humans. Immunohistochemical EPHX1 protein staining
additional information
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gene expression of EPHX1 in most tissues and anatomical compartments, by microarray, SAGE, and RNASeq, highest EPHX1 transcript and protein levels in liver and skin, high inter-individual variation among humans. Immunohistochemical EPHX1 protein staining
additional information
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wide tissue distribution in mammalian tissue, enzyme levels vary with environmental exposure, sex, and age
additional information
microsomal epoxide hydrolase (mEH) is expressed in multiple tissues, including the ovary
additional information
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microsomal epoxide hydrolase (mEH) is expressed in multiple tissues, including the ovary
additional information
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wide tissue distribution in mammalian tissue, enzyme levels vary with environmental exposure, sex, and age, growth hormones are involved in sexually dimorphic liver enzyme expression
additional information
microsomal epoxide hydrolase (mEH) is expressed in multiple tissues, including the ovary
additional information
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microsomal epoxide hydrolase (mEH) is expressed in multiple tissues, including the ovary
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