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3.3.2.9: microsomal epoxide hydrolase

This is an abbreviated version!
For detailed information about microsomal epoxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.9

Reaction

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine
+
H2O
=
2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol

Synonyms

alpha,beta fold epoxide hydrolase, alpha,beta-fold type EH, E1-b', EC 3.3.2.3, EC 4.2.1.63, EC 4.2.1.64, EH1, EH2, Eha, EHb, EPHX, EPHX 1, EPHX1, EPOX, epoxide hydrolase, HYL1, JH epoxide hydrolase, JHEH, juvenile hormone epoxide hydrolase, mEH, mEH-like protein, mEH1, mEPHX, microsomal, microsomal EH, microsomal EPHX1, Microsomal epoxide hydrolase, microsomal epoxide hydrolase 1, microsomal epoxide hydrolase-like protein, microsomal xenobiotic epoxide hydrolase, More, PNSO hydrolase, SEH, styrene-epoxide hydrolase, Tcjheh-r1, Tcjheh-r3, XEHase, xenobiotic epoxide hydrolase

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.9 microsomal epoxide hydrolase

Specific Activity

Specific Activity on EC 3.3.2.9 - microsomal epoxide hydrolase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00003
with cyano(6-methoxy-naphthalen-2-yl)methyl oxiran-2-ylmethyl carbonate as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.000085
-
liver microsomes, substrate styrene oxide
0.0001
with trans-diphenylpropene oxide as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.000124
-
liver microsomes, substrate styrene oxide
0.00019
0.0003
with trans-stilbene oxide as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.00035
-
liver microsomes, substrate allylbenzene oxide
0.00036
with 14,15-epoxyeicosatrienoic acid as substrate, at pH 8.0 and 30°C
0.00043
-
liver microsomes, substrate styrene oxide
0.00051
-
testis microsomes
0.0013
with trans-diphenylpropene oxide as substrate, at pH 7.0 and 30°C
0.0017
with juvenile hormone III as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.0027
30°C, pH not specified in the publication
0.0036
-
liver microsomes, substrate allylbenzene oxide
0.0037
with cyano-(6-methoxy-naphthalen-2-yl)-methyl 3,3-dimethyl-oxiranylmethyl carbonate as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.0045
-
enzyme form cytosol
0.0057
-
liver microsomes
0.0064
-
liver microsomes
0.0083
-
-
0.021
-
substrate 4-methyl-2-oxo-2H-chromen-7-yl oxiran-2-ylmethyl carbonate, pH 9.0, 37°C
0.023
-
substrate 4-nitrophenyl 3-(oxiran-2-yl)propanoate, pH 9.0, 37°C
0.025
-
substrate cyano(6-methoxy-naphthalen-2-yl)methyl glycidyl carbonate, pH 9.0, 37°C
0.0272
-
-
0.029
-
substrate 4-nitrophenyl 6-oxabicyclo[3.1.0]hexane-3-carboxylate, pH 9.0, 37°C
0.0293
with juvenile hormone III as substrate, at pH 8.0 and 30°C
0.0458
with cis-stilbene oxide as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.0475
with cis-stilbene oxide as substrate, at pH 7.0 and 30°C
0.048
-
substrate 4-methyl-2-oxo-2H-chromen-7-yl oxiran-2-ylmethyl carbonate, pH 9.0, 37°C
0.051
-
substrate 4-nitrophenyl 6-oxabicyclo[3.1.0]hexane-3-carboxylate, pH 9.0, 37°C
0.068
-
substrate cyano(6-methoxy-naphthalen-2-yl)methyl glycidyl carbonate, pH 9.0, 37°C
0.072
-
substrate 4-nitrophenyl 3-(oxiran-2-yl)propanoate, pH 9.0, 37°C
0.093
30°C, pH not specified in the publication
0.118
-
-
0.121
-
-
0.122
with cyano-(6-methoxy-naphthalen-2-yl)-methyl trans-((3-ethyl-oxiran-2-yl)methyl) carbonate as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.138
with cyano(2-methoxynaphthalen-6-yl)methyl trans-(2-(3-phenyloxiran-2-yl))acetate as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
0.618
-
-
0.659
-
enzyme from microsomes
0.816
with cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
1.18
with cyano(2-methoxynaphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl)acetate as substrate, in 100 mM sodium phosphate, pH 8.0, at 30°C
11.4
-
-
additional information