Reference on EC 3.3.2.9 - microsomal epoxide hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wixtrom, R.N.; Hammock, B.D.
Membrane-bound and soluble-fraction epoxide hydrolases
Biochem. Pharmacol. Toxicol.
1
1-93
1985
Oryctolagus cuniculus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
-
Seidegard, J.; DePierre, J.W.
Microsomal epoxide hydrolase. Properties, regulation and function
Biochim. Biophys. Acta
695
251-270
1983
Oryctolagus cuniculus, Rattus norvegicus
Lu, A.Y.H.; Miwa, G.T.
Molecular properties and biological functions of microsomal epoxide hydrase
Annu. Rev. Pharmacol. Toxicol.
20
513-531
1980
Homo sapiens, Rattus norvegicus
Oesch, F.
Epoxide hydratase
Prog. Drug Metab.
3
253-301
1979
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Mus musculus, Pigeon, quail, Rattus norvegicus, Sus scrofa, toad, trout
-
Oesch, F.
Epoxide hydratase
Mises Point Biochim. Pharmacol.
1
127-148
1977
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
-
Oesch, F.; Daly, J.
Solubilization, purification, and properties of a hepatic epoxide hydrase
Biochim. Biophys. Acta
227
692-697
1971
Cavia porcellus
Oesch, F.; Jerina, D.M.; Daly, J.W.
Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes
Arch. Biochem. Biophys.
144
253-261
1971
Cavia porcellus
Oesch, F.
Purification and specificity of a human microsomal epoxide hydratase
Biochem. J.
139
77-88
1974
Cavia porcellus, Homo sapiens, Rattus norvegicus
Lu, A.Y.H.; Ryan, D.; Jerina, D.M.; Daly, J.W.; Levin, W.
Liver microsomal expoxide hydrase. Solubilization, purification, and characterization
J. Biol. Chem.
250
8283-8288
1975
Rattus norvegicus
Bentley, P.; Oesch, F.
Purification of rat liver epoxide hydratase to apparent homogeneity
FEBS Lett.
59
291-295
1975
Rattus norvegicus
Knowles, R.G.; Burchell, B.
A simple method for purification of epoxide hydratase from rat liver
Biochem. J.
163
381-383
1977
Rattus norvegicus
Bentley, P.; Oesch, F.
Properties and amino acid composition of pure epoxide hydratase
FEBS Lett.
59
296-299
1975
Rattus norvegicus
Knowles, R.G.; Burchell, B.
Mouse liver epoxide hydratase: purification and identity with the rat liver enzyme
Biochem. Soc. Trans.
5
731-732
1977
Mus musculus
Lu, A.Y.H.; Levin, W.
Purification and assay of liver microsomal epoxide hydrase
Methods Enzymol.
52
193-200
1978
Rattus norvegicus
Yawetz, A.; Agosin, M.
Epoxide hydrase in Trypanosoma cruzi epimastigotes
Biochim. Biophys. Acta
585
210-219
1979
Trypanosoma cruzi
Bindel, U.; Sparrow, A.; Schmassmann, H.; Golan, M.; Bentley, P.; Oesch, F.
Endogenous role of epoxide-hydratase. Development of a steroid epoxide-hydratase assay and properties of the enzyme
Eur. J. Biochem.
97
275-281
1979
Rattus norvegicus
Lu, A.Y.H.; Thomas, P.E.; Ryan, D.; Jerina, D.M.; Levin, W.
Purification of human liver microsomal epoxide hydrase. Differences in the properties of the human and rat enzymes
J. Biol. Chem.
254
5878-5881
1979
Homo sapiens, Rattus norvegicus
Bornstein, W.A.; Levin, W.; Thomas, P.E.; Ryan, D.E.; Bresnick, E.
Comparison of nuclear and microsomal epoxide hydrase from rat liver
Arch. Biochem. Biophys.
197
436-446
1979
Rattus norvegicus
Guengerich, F.P.; Wang, P.; Mitchell, M.B.; Mason, P.S.
Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms
J. Biol. Chem.
254
12248-12254
1979
Homo sapiens, Rattus norvegicus
Ota, K.; Hammock, B.D.
Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver
Science
207
1479-1481
1980
Cavia porcellus, Mus musculus, Rattus norvegicus
Guenthner, T.M.; Bentley, P.; Oesch, F.
Microsomal epoxide hydrolase
Methods Enzymol.
77
344-349
1981
Rattus norvegicus
Vogel-Bindel, U.; Bentley, P.; Oesch, F.
Endogenous role of microsomal epoxide hydrolase. Ontogenesis, induction inhibition, tissue distribution, immunological behaviour and purification of microsomal epoxide hydrolase with 16alpha,17alpha-epoxyandrostene-3-one as substrate
Eur. J. Biochem.
126
425-431
1982
Rattus norvegicus
Wang, P.; Meijer, J.; Guengerich, F.P.
Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme
Biochemistry
21
5769-5776
1982
Homo sapiens
Guengerich, F.P.
Epoxide hydratase: properties and metabolic roles
Rev. Biochem. Toxicol.
4
5-30
1982
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
-
Guenthner, T.M.; Oesch, F.
Identification and characterization of a new epoxide hydrolase from mouse liver microsomes
J. Biol. Chem.
258
15054-15061
1983
Mus musculus
Chalmers, D.E.; Morgan, J.E.; Elwood, P.Y.; Brown, S.
Purification of epoxide hydrolase from mouse liver and properties of its antibody produced from rabbits
Biochem. Soc. Trans.
13
1153
1985
Mus musculus
-
Bulleid, N.J.; Graham, A.B.; Craft, J.A.
Microsomal epoxide hydrolase of rat liver. Purification and characterization of enzyme fractions with different chromatographic characteristics
Biochem. J.
233
607-611
1986
Rattus norvegicus
Papadopoulos, D.; Seidegard, J.; Georgellis, A.; Rydstroem, J.
Subcellular distribution, catalytic properties and partial purification of epoxide hydrolase in the human adrenal gland
Chem. Biol. Interact.
55
249-260
1985
Homo sapiens
Meijer, J.; Lundqvist, G.; DePierre, J.W.
Comparison of the sex and subcellular distributions, catalytic and immunochemical reactivities of hepatic epoxide hydrolases in seven mammalian species
Eur. J. Biochem.
167
269-279
1987
Cavia porcellus, Oryctolagus cuniculus, Cricetinae, Homo sapiens, Platyrrhini, Mus musculus
Moody, D.E.; Hammock, B.D.
Purification of microsomal epoxide hydrolase from liver of rhesus monkey: partial separation of cis- and trans-stilbene oxide hydrolase
Arch. Biochem. Biophys.
258
156-166
1987
Macaca mulatta
Beaune, P.H.; Cresteil, T.; Flinois, J.P.; Leroux, J.P.
Hydrophobic chromatography: a one-step method for the purification of human liver microsomal epoxide hydrolase
J. Chromatogr.
426
169-176
1988
Homo sapiens, Rattus norvegicus
Lacourciere, G.M.; Vakharia, V.N.; Tan, C.P.; Morris, D.I.; Edwards, G.H.; Moos, M.; Armstrong, R.N.
Interaction of hepatic microsomal epoxide hydrolase derived from a recombinent baculovirus expression system with an azarene oxide and an aziridine substrate analogue
Biochemistry
32
2610-2616
1993
Rattus norvegicus
Debernard, S.; Morisseau, C.; Severson, T.F.; Feng, L.; Wojtasek, H.; Prestwich, G.D.; Hammock, B.D.
Expression and characterization of the recombinant juvenile hormone epoxide hydrolase (JHEH) from Manduca sexta
Insect Biochem. Mol. Biol.
28
409-419
1998
Manduca sexta
Ariyoshi, N.; Tanaka, M.; Ishii, Y.; Oguri, K.
Purification and characterization of dog liver microsomal epoxide hydrolase
J. Biochem.
115
985-990
1994
Canis lupus familiaris
Touhara, K.; Prestwich, G.D.
Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs
J. Biol. Chem.
268
19604-19609
1993
Manduca sexta
Taura, K.i.; Yamada, H.; Naito, E.; Ariyoshi, N.; Mori, M.a.; Oguri, K.
Activation of microsomal epoxide hydrolase by interaction with cytochromes P450: kinetic analysis of the association and substrate-specific activation of epoxide hydrolase function
Arch. Biochem. Biophys.
402
275-280
2002
Rattus norvegicus
Summerer, S.; Hanano, A.; Utsumi, S.; Arand, M.; Schuber, F.; Blee, E.
Stereochemical features of the hydrolysis of 9,10-epoxystearic acid catalysed by plant and mammalian epoxide hydrolases
Biochem. J.
366
471-480
2002
Apium graveolens, Glycine max, Musa x paradisiaca, Nicotiana tabacum, Oryza sativa, Rattus norvegicus, Solanum tuberosum, Triticum aestivum, Zea mays
Li, C.; Liu, Q.; Song, X.; Ding, D.; Ji, A.; Qu, Y.
Epoxide hydrolase-catalyzed resolution of ethyl 3-phenylglycidate using whole cells of Pseudomonas sp
Biotechnol. Lett.
25
2113-2116
2003
Pseudomonas sp., Pseudomonas sp. BZS21
Kronenburg, N.A.E.; de Bont, J.A.M.
Effects of detergents on specific activity and enantioselectivity of the epoxide hydrolase from Rhodotorula glutinis
Enzyme Microb. Technol.
28
210-217
2001
Rhodotorula glutinis
Taniai, K.; Inceoglu, A.B.; Yukuhiro, K.; Hammock, B.D.
Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster
Eur. J. Biochem.
270
4696-4705
2003
Drosophila melanogaster (Q7KB18), Drosophila melanogaster
DuTeaux, S.B.; Newman, J.W.; Morisseau, C.; Fairbairn, E.A.; Jelks, K.; Hammock, B.D.; Miller, M.G.
Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism
Toxicol. Sci.
78
187-195
2004
Rattus norvegicus
Morisseau, C.; Hammock, B.D.
Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles
Annu. Rev. Pharmacol. Toxicol.
45
311-333
2005
Homo sapiens, Mus musculus, Rattus norvegicus
Levin, W.; Michaud, D.P.; Thomas, P.E.; Jerina, D.M.
Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6alpha-oxide and certain xenobiotic alkene and arene oxides
Arch. Biochem. Biophys.
220
485-494
1983
Rattus norvegicus
Watabe, T.; Ozawa, N.; Ishii, H.; Chiba, K.; Hiratsuka, A.
Hepatic microsomal cholesterol epoxide hydrolase: selective inhibition by detergents and separation from xenobiotic epoxide hydrolase
Biochem. Biophys. Res. Commun.
140
632-637
1986
Mus musculus
Dietze, E.C.; Kuwano, E.; Casa, J.; Hammock, B.D.
Inhibition of cytosolic epoxide hydrolase by trans-3-phenylglycidols
Biochem. Pharmacol.
42
1163-1175
1991
Mus musculus
Astroem, A.; Eriksson, M.; Eriksson, L.C.; Birberg, W.; Pilotti, A.; DePierre, J.W.
Subcellular and organ distribution of cholesterol epoxide hydrolase in the rat
Biochim. Biophys. Acta
882
359-366
1986
Rattus norvegicus
Robien, K.; Curtin, K.; Ulrich, C.M.; Bigler, J.; Samowitz, W.; Caan, B.; Potter, J.D.; Slattery, M.L.
Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk
Cancer Epidemiol. Biomarkers Prev.
14
1350-1352
2005
Homo sapiens
Lin, Y.C.; Wu D.C.; Lee, J.M.; Hsu, H.K.; Kao, E.L.; Yang, C.H.; Wu, M.T.
The association between microsomal epoxide hydrolase genotypes and esophageal sqamous-cell-carcinoma in Taiwan: interaction between areca chewing and smoking
Cancer Lett.
237
281-288
2006
Homo sapiens
Oesch, F.; Timms, C.W.; Walker, C.H.; Guenthner, T.M.; Sparrow, A.; Watabe, T.; Wolf, C.R.
Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities
Carcinogenesis
5
7-9
1984
Oryctolagus cuniculus, Rattus norvegicus
Lacourciere, G.M.; Armstrong, R.N.
Microsomal ans soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes
Chem. Res. Toxicol.
7
121-124
1994
Rattus norvegicus
Bellucci, G.; Chiappe, C.; Ingrosso, G.
Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides
Chirality
6
577-582
1994
Oryctolagus cuniculus
Liu, M.; Sun, A.; Shin, E.J.; Liu, X.; Kim, S.G.; Runyons, C.R.; Markesbery, W.; KIm, H.C.; Bing, G.
Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin
Eur. J. Neurosci.
23
2027-2034
2006
Homo sapiens, Rattus norvegicus
Park, J.Y.; Chen, L.; Wadhwa, N.; Tockman, M.S.
Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD
Int. J. Mol. Med.
15
443-448
2005
Homo sapiens
Sevanian, A.; McLeod, L.L.
Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase
J. Biol. Chem.
261
54-59
1986
Rattus norvegicus
Kim, H.S.; Lee, S.J.; Lee, E.J.; Hwang, J.W.; Park, S.; Kim, S.J.; Lee, E.Y.
Cloning and characterization of a fish microsomal epoxide hydrolase of Danio rerio and application to kinetic resolution of racemic styrene oxide
J. Mol. Catal. B
37
30-35
2005
Danio rerio
-
Liang, S.H.; Hassett, C.; Omiecinski, C.J.
Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1)
Mol. Pharmacol.
67
220-230
2005
Homo sapiens (P07099), Homo sapiens
Newman, J.W.; Morisseau, C.; Hammock, B.D.
Epoxide hydrolases: their roles and interactions with lipid metabolism
Prog. Lipid Res.
44
1-51
2005
Homo sapiens, Mus musculus, Rattus norvegicus
Lewis, D.F.V.; Lake, B.G.; Bird, M.G.
Molecular modelling of human microsomal epoxide hydrolase (EH) by homology with fungal (Aspergillus niger) EH crystal structure of 1.8 A resolution: structure-activity relationships in epoxides inhibiting EH activity
Toxicol. In Vitro
19
517-522
2005
Homo sapiens
Draper, A.J.; Hammock, B.D.
Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals
Toxicol. Sci.
52
26-32
1999
Homo sapiens, Mus musculus, Rattus norvegicus
Cornelis, M.C.; El-Sohemy, A.; Campos, H.
Microsomal epoxide hydrolase genotype and risk of myocardial infarction
Arch. Toxicol.
81
641-645
2007
Homo sapiens
Lee, S.J.; Kim, H.S.; Kim, S.J.; Park, S.; Kim, B.J.; Shuler, M.L.; Lee, E.Y.
Cloning, expression and enantioselective hydrolytic catalysis of a microsomal epoxide hydrolase from a marine fish, Mugil cephalus
Biotechnol. Lett.
29
237-246
2007
Mugil cephalus
Mittal, R.D.; Srivastava, D.L.
Cytochrome P4501A1 and microsomal epoxide hydrolase gene polymorphisms: gene-environment interaction and risk of prostate cancer
DNA Cell Biol.
26
791-798
2007
Homo sapiens
Chiappe, C.; Leandri, E.; Hammock, B.D.; Morisseau, C.
Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols
Green Chem.
9
162-168
2007
Rattus norvegicus
Matheson, M.C.; Raven, J.; Walters, E.H.; Abramson, M.J.; Ellis, J.A.
Microsomal epoxide hydrolase is not associated with COPD in a community-based sample
Hum. Biol.
78
705-717
2006
Homo sapiens
Ada, A.O.; Suzen, H.S.; Iscan, M.
Polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1 in a male Turkish population
Int. J. Toxicol.
26
41-46
2007
Homo sapiens
Lin, T.S.; Huang, H.H.; Fan, Y.H.; Chiou, S.H.; Chow, K.C.
Genetic polymorphism and gene expression of microsomal epoxide hydrolase in non-small cell lung cancer
Oncol. Rep.
17
565-572
2007
Homo sapiens (P07099), Homo sapiens
Salam, M.T.; Lin, P.C.; Avol, E.L.; Gauderman, W.J.; Gilliland, F.D.
Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma
Thorax
62
1050-1057
2007
Homo sapiens
Rajapaksa, K.S.; Sipes, I.G.; Hoyer, P.B.
Involvement of microsomal epoxide hydrolase enzyme in ovotoxicity caused by 7,12-dimethylbenz[a]anthracene
Toxicol. Sci.
96
327-334
2007
Mus musculus
Chappell, S.; Daly, L.; Morgan, K.; Guetta-Baranes, T.; Roca, J.; Rabinovich, R.; Lotya, J.; Millar, A.B.; Donnelly, S.C.; Keatings, V.; MacNee, W.; Stolk, J.; Hiemstra, P.S.; Miniati, M.; Monti, S.; OConnor, C.M.; Kalsheker, N.
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD
Eur. Respir. J.
32
931-937
2008
Homo sapiens
Srivastava, D.S.; Mandhani, A.; Mittal, R.D.
Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India
Arch. Toxicol.
82
633-639
2008
Homo sapiens
Decker, M.; Arand, M.; Cronin, A.
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
Arch. Toxicol.
83
297-318
2009
Homo sapiens, Mus musculus
Cheong, A.W.; Lee, Y.L.; Liu, W.M.; Yeung, W.S.; Lee, K.F.
Oviductal microsomal epoxide hydrolase (EPHX1) reduces reactive oxygen species (ROS) level and enhances preimplantation mouse embryo development
Biol. Reprod.
81
126-132
2009
Homo sapiens, Mus musculus
Morisseau, C.; Newman, J.W.; Wheelock, C.E.; Hill Iii, T.; Morin, D.; Buckpitt, A.R.; Hammock, B.D.
Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase
Chem. Res. Toxicol.
21
951-957
2008
Rattus norvegicus
Zidzik, J.; Slaba, E.; Joppa, P.; Kluchova, Z.; Dorkova, Z.; Skyba, P.; Habalova, V.; Salagovic, J.; Tkacova, R.
Glutathione S-transferase and microsomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease in Slovak population
Croat. Med. J.
49
182-191
2008
Homo sapiens
Kiran, M.; Chawla, Y.K.; Kaur, J.
Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India
DNA Cell Biol.
27
687-694
2008
Homo sapiens
Lacko, M.; Roelofs, H.M.; Te Morsche, R.H.; Voogd, A.C.; Oude Ophuis, M.B.; Peters, W.H.; Manni, J.J.
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer
Head Neck
30
836-844
2008
Homo sapiens
Liu, M.; Hunter, R.; Nguyen, X.V.; Kim, H.C.; Bing, G.
Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment
J. Neurosci. Res.
86
2792-2801
2008
Mus musculus
Rawal, S.; Morisseau, C.; Hammock, B.D.; Shivachar, A.C.
Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes
J. Neurosci. Res.
87
218-227
2009
Rattus norvegicus
Yang, X.; Liang, S.H.; Weyant, D.M.; Lazarus, P.; Gallagher, C.J.; Omiecinski, C.J.
The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter
J. Pharmacol. Exp. Ther.
330
23-30
2009
Homo sapiens
Graziano, C.; Comin, C.E.; Crisci, C.; Novelli, L.; Politi, L.; Messerini, L.; Andreani, M.; Porfirio, B.
Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series
Lung Cancer
63
187-193
2009
Homo sapiens
Pushparajah, D.S.; Umachandran, M.; Plant, K.E.; Plant, N.; Ioannides, C.
Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices
Mutat. Res.
640
153-161
2008
Homo sapiens, Rattus norvegicus
Ockenga, J.; Strunck, S.; Post, C.; Schulz, H.U.; Halangk, J.; Pfuetzer, R.H.; Loehr, M.; Oettle, H.; Kage, A.; Rosendahl, J.; Keim, V.; Drenth, J.P.; Jansen, J.B.; Lochs, H.; Witt, H.
The role of epoxide hydrolase Y113H gene variant in pancreatic diseases
Pancreas
38
e97-e101
2009
Homo sapiens
Morisseau, C.; Hammock, B.D.
Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical
Pest Manag. Sci.
64
594-609
2008
Homo sapiens, Mus musculus
Hu, G.; Shi, Z.; Hu, J.; Zou, G.; Peng, G.; Ran, P.
Association between polymorphisms of microsomal epoxide hydrolase and COPD: results from meta-analyses
Respirology
13
837-850
2008
Homo sapiens
Keating, A.F.; Sipes, I.G.; Hoyer, P.B.
Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F(1) mice
Toxicol. Appl. Pharmacol.
230
109-116
2008
Mus musculus, Mus musculus B6C3F1
Jain, M.; Tilak, A.R.; Upadhyay, R.; Kumar, A.; Mittal, B.
Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer
Toxicol. Appl. Pharmacol.
230
247-251
2008
Homo sapiens
Keating, A.F.; Rajapaksa, K.S.; Sipes, I.G.; Hoyer, P.B.
Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure
Toxicol. Sci.
105
351-359
2008
Mus musculus, Mus musculus 129S1/SvImJ
Makmor-Bakry, M.; Sills, G.J.; Hitiris, N.; Butler, E.; Wilson, E.A.; Brodie, M.J.
Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing
Clin. Neuropharmacol.
32
205-212
2009
Homo sapiens
Kiran, M.; Chawla, Y.K.; Jain, M.; Kaur, J.
Haplotypes of microsomal epoxide hydrolase and x-ray cross-complementing group 1 genes in Indian hepatocellular carcinoma patients
DNA Cell Biol.
28
573-577
2009
Homo sapiens
Lee, J.; Nordestgaard, B.G.; Dahl, M.
EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis
Eur. Respir. J.
37
18-25
2011
Homo sapiens
Popp, S.L.; Abele, I.S.; Buck, M.B.; Stope, M.B.; Blok, L.J.; Hanifi-Moghaddam, P.; Burger, C.W.; Fritz, P.; Knabbe, C.
Microsomal epoxide hydrolase expression in the endometrial uterine corpus is regulated by progesterone during the menstrual cycle
J. Mol. Histol.
41
111-119
2010
Homo sapiens
Shin, E.J.; Bing, G.; Chae, J.S.; Kim, T.W.; Bach, J.H.; Park, D.H.; Yamada, K.; Nabeshima, T.; Kim, H.C.
Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice
J. Neurosci. Res.
87
3679-3686
2009
Mus musculus
Marowsky, A.; Burgener, J.; Falck, J.R.; Fritschy, J.M.; Arand, M.
Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism
Neuroscience
163
646-661
2009
Mus musculus, Mus musculus C57BL/6
Morisseau, C.; Bernay, M.; Escaich, A.; Sanborn, J.R.; Lango, J.; Hammock, B.D.
Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies
Anal. Biochem.
414
154-162
2011
Homo sapiens, Rattus norvegicus
Abdull Razis, A.F.; Bagatta, M.; De Nicola, G.R.; Iori, R.; Ioannides, C.
Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality
Arch. Toxicol.
85
919-927
2011
Rattus norvegicus
Tsubota, T.; Nakakura, T.; Shiotsuki, T.
Molecular characterization and enzymatic analysis of juvenile hormone epoxide hydrolase genes in the red flour beetle Tribolium castaneum
Insect Mol. Biol.
19
399-408
2010
Tribolium castaneum (D0W011), Tribolium castaneum (D0W013), Tribolium castaneum (D0W014), Tribolium castaneum
Bhattacharya, P.; Sen, N.; Hoyer, P.B.; Keating, A.F.
Ovarian expressed microsomal epoxide hydrolase: Role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling
Toxicol. Appl. Pharmacol.
258
118-123
2011
Mus musculus, Rattus norvegicus, Rattus norvegicus (P07687)
Kamita, S.G.; Oshita, G.H.; Wang, P.; Morisseau, C.; Hammock, B.D.; Nandety, R.S.; Falk, B.W.
Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis
Arch. Insect Biochem. Physiol.
83
171-179
2013
Homalodisca vitripennis (S4UPN4), Homalodisca vitripennis
Chen, J.Y.; Chen, W.N.; Jiao, B.Y.; Lin, W.S.; Wu, Y.L.; Liu, L.L.; Lin, X.
Hepatitis B spliced protein (HBSP) promotes the carcinogenic effects of benzo [alpha] pyrene by interacting with microsomal epoxide hydrolase and enhancing its hydrolysis activity
BMC Cancer
14
282
2014
Mus musculus, Homo sapiens (P07099)
Kamita, S.G.; Yamamoto, K.; Dadala, M.M.; Pha, K.; Morisseau, C.; Escaich, A.; Hammock, B.D.
Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens
Insect Biochem. Mol. Biol.
43
219-228
2013
Heliothis virescens (L7R9X8), Heliothis virescens
Nithipatikom, K.; Endsley, M.P.; Pfeiffer, A.W.; Falck, J.R.; Campbell, W.B.
A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol
J. Lipid Res.
55
2093-2102
2014
Homo sapiens
Shen, W.; Fang, Y.; Tong, A.; Zhu, Q.
Synthesis and structure-activity relationship of acylthiourea derivatives as inhibitors of microsomal epoxide hydrolase
Med. Chem. Res.
21
4214-4218
2012
Homo sapiens
-
Nguyen, H.L.; Yang, X.; Omiecinski, C.J.
Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5-untranslated region
RNA
19
752-766
2013
Homo sapiens
Duan, H.; Takagi, A.; Kayano, H.; Koyama, I.; Morisseau, C.; Hammock, B.D.; Akatsuka, T.
Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase
Toxicol. Appl. Pharmacol.
260
27-34
2012
Homo sapiens
Li, X.Q.; Hayes, M.A.; Groenberg, G.; Berggren, K.; Castagnoli, N.Jr.; Weidolf, L.
Discovery of a novel microsomal epoxide hydrolase-catalyzed hydration of a spiro oxetane
Drug Metab. Dispos.
44
1341-1348
2016
Homo sapiens
Li, N.; Zhang, Y.; Feng, H.
Biochemical characterization and transcriptional analysis of the epoxide hydrolase from white-rot fungus Phanerochaete chrysosporium
Acta Biochim. Biophys. Sin. (Shanghai)
41
638-647
2009
Phanerodontia chrysosporium (B0FSQ0)
Marowsky, A.; Haenel, K.; Bockamp, E.; Heck, R.; Rutishauser, S.; Mule, N.; Kindler, D.; Rudin, M.; Arand, M.
Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation
Arch. Toxicol.
90
3017-3027
2016
Mus musculus (Q9D379)
Toselli, F.; Fredenwall, M.; Svensson, P.; Li, X.Q.; Johansson, A.; Weidolf, L.; Hayes, M.A.
Oxetane substrates of human microsomal epoxide hydrolase
Drug Metab. Dispos.
45
966-973
2017
Homo sapiens (P07099), Homo sapiens
Manickam, M.; Pillaiyar, T.; Boggu, P.; Venkateswararao, E.; Jalani, H.B.; Kim, N.D.; Lee, S.K.; Jeon, J.S.; Kim, S.K.; Jung, S.H.
Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase
Eur. J. Med. Chem.
117
113-124
2016
Oryctolagus cuniculus (P04068)
Vaclavikova, R.; Hughes, D.J.; Soucek, P.
Microsomal epoxide hydrolase 1 (EPHX1) Gene, structure, function, and role in human disease
Gene
571
1-8
2015
Agrobacterium tumefaciens (O31243), Homo sapiens (P07099), Homo sapiens, Aspergillus niger (Q5EC68), Mus musculus (Q9D379)
Levy, D.
The role of microsomal epoxide hydrolase, Na+-taurocholate cotransporting polypeptide, and organic anion transporting polypeptide in hepatic sodium-dependent bile acid transport
Hepatology
67
1184-1185
2018
Homo sapiens (P07099)
Yamanashi, H.; Boeglin, W.E.; Morisseau, C.; Davis, R.W.; Sulikowski, G.A.; Hammock, B.D.; Brash, A.R.
Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function
J. Lipid Res.
59
684-695
2018
Homo sapiens (P07099)
Nabi, S.; Bhat, G.A.; Iqbal, B.; Lone, M.M.; Lone, G.N.; Khan, M.A.; Dar, N.A.
Association of activity altering genotypes - Tyr113His and His139Arg in microsomal epoxide hydrolase enzyme with esophageal squamous cell carcinoma
Nutr. Cancer
71
806-817
2019
Homo sapiens (P07099), Homo sapiens
Sun, P.; Leeson, C.; Zhi, X.; Leng, F.; Pierce, R.H.; Henry, M.S.; Rein, K.S.
Characterization of an epoxide hydrolase from the Florida red tide dinoflagellate, Karenia brevis
Phytochemistry
122
11-21
2016
Karenia brevis
Peng, H.; Zhu, Q.S.; Zhong, S.; Levy, D.
Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by PARP-1 and histone H1.2. association with sodium-dependent Bile acid transport
PLoS ONE
10
e0125318
2015
Homo sapiens (P07099), Homo sapiens
Saenz-Mendez, P.; Katz, A.; Perez-Kempner, M.L.; Ventura, O.N.; Vazquez, M.
Structural insights into human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations
Proteins
85
720-730
2017
Homo sapiens (P07099), Homo sapiens
Bhattacharya, P.; Sen, N.; Hoyer, P.B.; Keating, A.F.
Ovarian expressed microsomal epoxide hydrolase role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling
Toxicol. Appl. Pharmacol.
258
118-23
2012
Rattus norvegicus (P07687), Mus musculus (Q9D379), Mus musculus, Rattus norvegicus Fischer 344 (P07687)
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