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Literature summary for 3.3.2.9 extracted from

  • Nabi, S.; Bhat, G.A.; Iqbal, B.; Lone, M.M.; Lone, G.N.; Khan, M.A.; Dar, N.A.
    Association of activity altering genotypes - Tyr113His and His139Arg in microsomal epoxide hydrolase enzyme with esophageal squamous cell carcinoma (2019), Nutr. Cancer, 71, 806-817 .
    View publication on PubMed
Search for more literature for 3.3.2.9

Cloned(Commentary)

Cloned (Comment) Organism
gene EPHX1, mEH genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
H139R naturally occuring enzyme mutation, a polymorphism in exon 4, involved in development of esophageal squamous cell carcinoma Homo sapiens
additional information significant interaction is seen between mEH exon 3 and exon 4 genotypes and between predicted mEH activity and positive family history of cancer suggesting an association of ESCC risk with mEH polymorphisms which get modified by tobacco smoking and positive family history of cancer Homo sapiens
Y113H naturally occuring enzyme mutation, a polymorphism in exon 3, involved in development of esophageal squamous cell carcinoma (ESCC), exon 3 slow genotype predicts low mEH activity associated with the ESCC risk. Elevated ESCC risk estimates are seen in smokers independent of genotypes but the association is stronger among smokers with exon 3 variant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme mEH in collaboration with cytochrome-P-450 (CYP) converts benzo(a)pyrene to more reactive intermediate, benzo(a)pyrene-7,8-dihydrodiol 8,9-epoxide (benzo(a)pyrene diolepoxide, BPDE) which displays higher mutagenic and carcinogenic potential than its substrate ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07099
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-

Source Tissue

Source Tissue Comment Organism Textmining
esophageal squamous cell carcinoma cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme mEH in collaboration with cytochrome-P-450 (CYP) converts benzo(a)pyrene to more reactive intermediate, benzo(a)pyrene-7,8-dihydrodiol 8,9-epoxide (benzo(a)pyrene diolepoxide, BPDE) which displays higher mutagenic and carcinogenic potential than its substrate Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
EPHX1
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 Homo sapiens
mEH
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 Homo sapiens
Microsomal epoxide hydrolase
-
 Homo sapiens

General Information

General Information Comment Organism
additional information mEH phenotyping of wild-type and naturally occuring mutants Y113H and H139R Homo sapiens