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Literature summary for 3.3.2.9 extracted from

  • Liang, S.H.; Hassett, C.; Omiecinski, C.J.
    Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1) (2005), Mol. Pharmacol., 67, 220-230.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.9

Cloned(Commentary)

Cloned (Comment) Organism
the E1-b promoter functions as the primary driver of EPHX1 expression in human tissues, E1 promoter directs expression only in the liver, analysis of promoters and regulation enzyme expression in tissues, expression in Hep-G2 cells and 293A cells, co-expression of GATA-4, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information HNF3 negatively regulates the transactivation of E1 promoter by GATA-4 in hepatoma cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cis-stilbene oxide + H2O Homo sapiens
-
 (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07099 mEH is single gene-encoded
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell hepatoma cell line Homo sapiens
-
liver tissue-specific expression of the enzyme in liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-stilbene oxide + H2O
-
 Homo sapiens (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Synonyms

Synonyms Comment Organism
EPHX1
-
 Homo sapiens
mEH
-
 Homo sapiens