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3.3.2.9: microsomal epoxide hydrolase

This is an abbreviated version!
For detailed information about microsomal epoxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.9

Reaction

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine
+
H2O
=
2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol

Synonyms

alpha,beta fold epoxide hydrolase, alpha,beta-fold type EH, E1-b', EC 3.3.2.3, EC 4.2.1.63, EC 4.2.1.64, EH1, EH2, Eha, EHb, EPHX, EPHX 1, EPHX1, EPOX, epoxide hydrolase, HYL1, JH epoxide hydrolase, JHEH, juvenile hormone epoxide hydrolase, mEH, mEH-like protein, mEH1, mEPHX, microsomal, microsomal EH, microsomal EPHX1, Microsomal epoxide hydrolase, microsomal epoxide hydrolase 1, microsomal epoxide hydrolase-like protein, microsomal xenobiotic epoxide hydrolase, More, PNSO hydrolase, SEH, styrene-epoxide hydrolase, Tcjheh-r1, Tcjheh-r3, XEHase, xenobiotic epoxide hydrolase

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.9 microsomal epoxide hydrolase

Expression

Expression on EC 3.3.2.9 - microsomal epoxide hydrolase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
4-vinylcyclohexene diepoxide (VCD) increases mRNA and protein expression of microsomal epoxide hydrolase (mEH). mEH mRNA and enzyme activity expression are shown to increase in small pre-antral follicles of mouse ovaries following repeated daily dosing (15d) with VCD
CEBPA (116897) interacts with DNA-bound NFY (A subunit, 189903, B subunit, 189904, C subunit, 605344) as an additional regulator of EPHX1 expression. Nuclear receptors HNF4A (600281), CAR (NR1I3, 603881), and RXR (RXRA, 180245 and RXRB, 180246) also bind to the proximal EPHX1 promoter region and regulate its expression in human hepatocytes
enzyme mRNA and protein level do not change until 4 days after 4-vinylcyclohexene diepoxide exposure (0.03 mM)
exposure to 4-vinylcyclohexene results in increased mRNA and protein expression of microsomal epoxide hydrolase
-
GATA4 (OMIM: 600576) is the major activator of EPHX1 expression. EPHX1 expression is induced by phenobarbital, beta-naphthoflavone, benzanthracene, and trans-stilbene oxide in human fetal hepatocytes in vitro
HNF3 (FOXA1, 602294 and FOXB1, 600288) acts as a co-repressor in HepG2 cells
increase of mEH expression after treatment with medroxy-progesterone 17-acetate in the estrogene receptor alpha-containing ECC1-PRAB72 cells, but not in estrogene receptor alpha-negative IKPRAB-36 cells
-
inhibition of PI3K signaling increases mEH mRNA and protein expression. In a post-natal day 4 Fischer 344 rat whole ovary culture system, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days
mEH expression is regulated by progesterone, but only in the presence of the progesterone receptors as well as estrogene receptor alpha, overview
-
methyl-2-cyano-3,12-dioxooleana-1,9(11)dien-28-oate is a potent inducer of transcription factor Nrf2 (nuclear factor, erythroid derived 2) and significantly alters the expression of EPHX1 protein in mice indicating a potential role of redox homeostasis in EPHX1 expression
relative to controls, meh mRNA is increased on day 4 of 4-vinylcyclohexene diepoxide exposure, followed by increased mEH protein after 6 days. Inhibition of phosphatidyinositol-3 kinase signaling increases mEH mRNA and protein expression
repeated administration of methamphetamine, METH, results in an increase in mEH-positive glia-like cells, mobilization of astroglial cells to synthesize mEH in response to METH
-
the enzyme's protein level is significantly increased by phosphatidyinositol-3 kinase inhibition by 221% on day 4 and 14% on day 6 relative to control-treated ovaries
transcripts of Eha can be detected under the ligninolytic and nonligninolytic conditions as well as induced by anthracene