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3.3.2.9: microsomal epoxide hydrolase

This is an abbreviated version!
For detailed information about microsomal epoxide hydrolase, go to the full flat file.

Word Map on EC 3.3.2.9

Reaction

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine
+
H2O
=
2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol

Synonyms

alpha,beta fold epoxide hydrolase, alpha,beta-fold type EH, E1-b', EC 3.3.2.3, EC 4.2.1.63, EC 4.2.1.64, EH1, EH2, Eha, EHb, EPHX, EPHX 1, EPHX1, EPOX, epoxide hydrolase, HYL1, JH epoxide hydrolase, JHEH, juvenile hormone epoxide hydrolase, mEH, mEH-like protein, mEH1, mEPHX, microsomal, microsomal EH, microsomal EPHX1, Microsomal epoxide hydrolase, microsomal epoxide hydrolase 1, microsomal epoxide hydrolase-like protein, microsomal xenobiotic epoxide hydrolase, More, PNSO hydrolase, SEH, styrene-epoxide hydrolase, Tcjheh-r1, Tcjheh-r3, XEHase, xenobiotic epoxide hydrolase

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.9 microsomal epoxide hydrolase

IC50 Value

IC50 Value on EC 3.3.2.9 - microsomal epoxide hydrolase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0005 - 0.14
(9E)-octadec-9-enamide
0.00016
1,3-dicyclohexylurea
Homo sapiens
-
pH and temperature not specified in the publication
0.0012
1,3-diphenylurea
Homo sapiens
-
pH and temperature not specified in the publication
0.0011 - 0.2
12-hydroxyoctadecanamide
0.0004 - 0.006
2-(nonylsulfanyl)propanamide
0.0022
7-oxabicyclo[4.1.0]heptane
Mus musculus
-
IC50 is 0.0022 mM
6.99
beta-dimethylstyrene oxide
Karenia brevis
-
pH 7.0, 30°C
3.05
cis-beta-methylstyrene oxide
Karenia brevis
-
pH 7.0, 30°C
0.0000079
methoxyarachidonyl fluorophosphate
Homo sapiens
-
at pH 7.4 and 37°C
0.00235
N-(phenylcarbamothioyl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00129
N-(phenylcarbamothioyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00207
N-(pyridin-4-ylcarbamothioyl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00228
N-(pyridin-4-ylcarbamothioyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0027
N-(tert-butylcarbamothioyl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00158
N-(tert-butylcarbamothioyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00112
N-acetyl-N'-adamantyl thiourea
Homo sapiens
-
pH and temperature not specified in the publication
0.00139
N-acetyl-N'-[(3-trifluoromethyl-4-bromo)phenyl] thiourea
Homo sapiens
-
pH and temperature not specified in the publication
0.00101
N-benzoyl-N'-adamantyl thiourea
Homo sapiens
-
pH and temperature not specified in the publication
0.00117
N-benzoyl-N'-[(3-trifluoromethyl-4-bromo)phenyl] thiourea
Homo sapiens
-
pH and temperature not specified in the publication
0.00229
N-[(2,6-dichlorophenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00215
N-[(2,6-dichlorophenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00253
N-[(2,6-diethoxyphenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00204
N-[(2,6-diethoxyphenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00169
N-[(2-methoxy-4-methylphenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00254
N-[(2-methoxy-4-methylphenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00187
N-[(2-methoxy-4-nitrophenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00165
N-[(2-methoxy-4-nitrophenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0015
N-[(2-methylphenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00354
N-[(2-methylphenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00242
N-[(4-bromonaphthalen-1-yl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00188
N-[(4-bromonaphthalen-1-yl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00164
N-[(4-bromophenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00344
N-[(4-bromophenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00221
N-[(4-chlorophenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00164
N-[(4-chlorophenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0037
N-[(4-phenoxyphenyl)carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0021
N-[(4-phenoxyphenyl)carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00259
N-[[4-(morpholin-4-yl)phenyl]carbamothioyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00172
N-[[4-(morpholin-4-yl)phenyl]carbamothioyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
14.28
trans-beta-methylstyrene oxide
Karenia brevis
-
pH 7.0, 30°C