3.2.1.62: glycosylceramidase

This is an abbreviated version!
For detailed information about glycosylceramidase, go to the full flat file.

Reaction

Synonyms

cerebrosidase, EGC, EGCII, EGCrP1, Egh1, endo-glycoceramidase II, endoglycoceramidase II, endoglycoceramidase-related protein 1, ergosteryl-beta-glucosidase, Gcase, glucocerebrosidase, glycosyl ceramide glycosylhydrolase, glycosyl-N-acylsphingosine glycohydrolase, glycosylceramidase, KLotho lactase phlorizin hydrolase, Klotho-related protein, lactase phlorizin hydrolase, lactase-phlorizin hydrolase, LCT, LPH, LPH1, phloretin-glucosidase, phloridzin glucosidase, phlorizin beta-glucosidase, phlorizin hydrolase, Yir007w

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.62 glycosylceramidase

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Results	in table
11	Activating Compound
15	AA Sequence
7	Application
1	CAS Registry Number
16	Cloned(Commentary)
3	Crystallization (Commentary)
94	Disease/ Diagnostics
9	General Information
2	General Stability
1	IC50 Value
62	Inhibitors
4	kcat/KM [mM/s]
5	Ki Value [mM]
73	KM Value [mM]
27	Localization
1	Metals/Ions
27	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
125	Organism
6	Pathway
15	pH Optimum
2	pH Range
2	pH Stability
13	Posttranslational Modification
23	Protein Variants
22	Purification (Commentary)
4	Reaction
9	Reaction Type
56	Reference
46	Source Tissue
26	Specific Activity [micromol/min/mg]
2	Storage Stability
198	Substrates and Products (Substrate)
16	Subunits
77	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
17	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.2.1.62 - glycosylceramidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

cis-aconitic acid

Macaca radiata

-

more than 2fold stimulation only for phlorizin activity

208763

Citric acid

Macaca radiata

-

highest stimulation at 50 mM and 30°C only for phlorizin activity

208763

EDTA

Cryptococcus neoformans

H1AE12

about 120% activity at 1 mM

732073

isocitric acid

Macaca radiata

-

1.7fold stimulation only for phlorizin activity

208763

L-ascorbic acid

Macaca radiata

-

1.6fold stimulation only for phlorizin activity

208763

L-Tartaric acid

Macaca radiata

-

most stimulating effect only for phlorizin activity

208763

Pyruvic acid

Macaca radiata

-

0.5fold stimulation only for phlorizin activity

208763

sodium cholate

Homo sapiens

-

increases the solubility of the substrates

680835

taurodeoxycholate

Mus musculus

-

activation

208758

additional information

2 entries

-

additional information

Homo sapiens

-

presence of Rab8T22N–CFP results in an increase in LPH–YFP-containing vesicular structures

701338

-

additional information

Rattus norvegicus

-

higher expression and gene transcription of LPH in jejunum of rats fed a high-carbohydrate/low-fat diet compared with those fed a low carbohydrate/high-fat diet. In vitro binding of the caudal homeobox protein Cdx-2, which is important for intestinal gene expression and differentiation, to the homeodomain protein-binding element CE-LPH1 in jejunal nuclear extracts is associated with the higher expression of LPH

699936

-