3.2.1.62: glycosylceramidase

This is an abbreviated version!
For detailed information about glycosylceramidase, go to the full flat file.

Reaction

Synonyms

cerebrosidase, EGC, EGCII, EGCrP1, Egh1, endo-glycoceramidase II, endoglycoceramidase II, endoglycoceramidase-related protein 1, ergosteryl-beta-glucosidase, Gcase, glucocerebrosidase, glycosyl ceramide glycosylhydrolase, glycosyl-N-acylsphingosine glycohydrolase, glycosylceramidase, KLotho lactase phlorizin hydrolase, Klotho-related protein, lactase phlorizin hydrolase, lactase-phlorizin hydrolase, LCT, LPH, LPH1, phloretin-glucosidase, phloridzin glucosidase, phlorizin beta-glucosidase, phlorizin hydrolase, Yir007w

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.62 glycosylceramidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
11	Activating Compound
15	AA Sequence
7	Application
1	CAS Registry Number
16	Cloned(Commentary)
3	Crystallization (Commentary)
94	Disease/ Diagnostics
9	General Information
2	General Stability
1	IC50 Value
62	Inhibitors
4	kcat/KM [mM/s]
5	Ki Value [mM]
73	KM Value [mM]
27	Localization
1	Metals/Ions
27	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
125	Organism
6	Pathway
15	pH Optimum
2	pH Range
2	pH Stability
13	Posttranslational Modification
23	Protein Variants
22	Purification (Commentary)
4	Reaction
9	Reaction Type
56	Reference
46	Source Tissue
26	Specific Activity [micromol/min/mg]
2	Storage Stability
198	Substrates and Products (Substrate)
16	Subunits
77	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
17	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Systematic Name on EC 3.2.1.62 - glycosylceramidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

beta-D-glucosyl-N-acylsphingosine glycohydrolase (configuration-retaining)

The enzyme, found in the intestinal mucosa, hydrolyses beta-D-glucosyl and beta-D-galactosyl residues from a very broad range of substrates using a retaining mechanism. Characterized substrates include glucosyl- and galactosyl-ceramides [3], O3-, O4'- and O7-glucosylated flavonoids [6], and the 2'-O-glucosylated dihydrochalcone phlorizin [1]. The enzyme includes two glycosyl hydrolase domains, both belonging to the GH1 family. While one domain is responsible for the activity described here, the other catalyses the reaction of EC 3.2.1.108, lactase [4,5]. cf. EC 3.2.1.45, glucosylceramidase and EC 3.2.1.46, galactosylceramidase.