3.1.4.52: cyclic-guanylate-specific phosphodiesterase

This is an abbreviated version!
For detailed information about cyclic-guanylate-specific phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.52

3.1.4.52

cyclases

c-di-gmp-dependent

dsf

diguanosine

c-di-gmp-binding

Reaction

Synonyms

Arr, BB0374, BCG_1419c, Bd1817, BifA, BinA, Blrp, BlrP1, blue light-regulated phophodiesterase, BpdA, BpdB, c-di-GMP phosphodiesterase, c-di-GMP-hydrolyzing-phosphodiesterase, c-di-GMP-specific PDE, c-di-GMP-specific phosphodiesterase, CC3396, CD0757, CdgC, CdpA, cyclic di-GMP phosphodiesterase, cyclic di-GMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic-di-GMP phosphodiesterase, diguanylate cyclase/phosphodiesterase, Dos, EAL, EAL domain phosphodiesterase, FimX, GAF/HD-GYP protein, H-NOX-associated cyclic-di-GMP processing enzyme, HaCE, HD-GYP, HD-GYP domain cyclic di-GMP phosphodiesterases, HD-GYP domain cyclic dimeric GMP phosphodiesterase, HD-GYP domain cyclic-di-GMP phosphodiesterase, HD-GYP PDE, HD-GYP phosphodiesterase, MbaA, MtbDGC, MtbPDE, PA2567, PA3947, PA4108, PA4367, PA4781, PAS-GGDEF-EAL domain-containing protein, PDE, PDE-A, PdeA, PDEA1, PdeB, PdeC, PdeH, perma_0986, phosphodiesterase A, PmGH, Putative uncharacterized protein, RapA, RavR, RbdA, RocR, RpfG, RpfR, ScrG, SO0437, TM0186, TM_0186, VieA, YahA, YcgF, YfgF

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.52 cyclic-guanylate-specific phosphodiesterase

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Results	in table
5	Activating Compound
21324	AA Sequence
1	CAS Registry Number
28	Cloned(Commentary)
2	Cofactor
4	Crystallization (Commentary)
4	Expression
38	General Information
15	Inhibitors
9	kcat/KM [mM/s]
41	KM Value [mM]
5	Localization
22	Metals/Ions
11	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
65	Organism
30	PDB ID
12	pH Optimum
3	pH Range
1	Posttranslational Modification
115	Protein Variants
16	Purification (Commentary)
2	Reaction
5	Reaction Type
55	Reference
1	Renatured (Commentary)
1	Source Tissue
3	Specific Activity [micromol/min/mg]
53	Substrates and Products (Substrate)
26	Subunits
134	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
48	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.1.4.52 - cyclic-guanylate-specific phosphodiesterase

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3',5'-di-cGMP + H2O

5'-phosphoguanylyl-(3'->5')guanosine

3 entries

5'-phosphoguanylyl(3'-5')guanosine + H2O

guanosine 5'-monophosphate + guanosine

Caulobacter vibrioides

680630

5'-phosphoguanylyl(3'->5')guanosine + H2O

GMP + guanosine

Pseudomonas aeruginosa

Q9HV27, Q9HWS0

the isozyme hydrolyses c-di-GMP in a two-step reaction via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine, it produces GMP in vitro at a low rate, reaction of EC 3.1.4.1

730749

5'-phosphoguanylyl-(3'->5')guanosine + H2O

2 5'-GMP

3 entries

c-di-GMP + H2O

2 entries

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

15 entries

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'->5')guanosine

6 entries

cyclic di-3',5'-guanylate + H2O

5'phosphoguanylyl(3'-5')guanosine

2 entries

cyclic-di-GMP + H2O

5'-pGpG

Pseudomonas aeruginosa

Q9HX69

692857

additional information

16 entries