3.1.4.52: cyclic-guanylate-specific phosphodiesterase This is an abbreviated version! For detailed information about cyclic-guanylate-specific phosphodiesterase, go to the full flat file .
Word Map on EC 3.1.4.52
Reaction
cyclic di-3',5'-guanylate +
H2O =
5'-phosphoguanylyl(3'->5')guanosine
Synonyms Arr, BB0374, BCG_1419c, Bd1817, BifA, BinA, Blrp, BlrP1, blue light-regulated phophodiesterase, BpdA, BpdB, c-di-GMP phosphodiesterase, c-di-GMP-hydrolyzing-phosphodiesterase, c-di-GMP-specific PDE, c-di-GMP-specific phosphodiesterase, CC3396, CD0757, CdgC, CdpA, cyclic di-GMP phosphodiesterase, cyclic di-GMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic-di-GMP phosphodiesterase, diguanylate cyclase/phosphodiesterase, Dos, EAL, EAL domain phosphodiesterase, FimX, GAF/HD-GYP protein, H-NOX-associated cyclic-di-GMP processing enzyme, HaCE, HD-GYP, HD-GYP domain cyclic di-GMP phosphodiesterases, HD-GYP domain cyclic dimeric GMP phosphodiesterase, HD-GYP domain cyclic-di-GMP phosphodiesterase, HD-GYP PDE, HD-GYP phosphodiesterase, MbaA, MtbDGC, MtbPDE, PA2567, PA3947, PA4108, PA4367, PA4781, PAS-GGDEF-EAL domain-containing protein, PDE, PDE-A, PdeA, PDEA1, PdeB, PdeC, PdeH, perma_0986, phosphodiesterase A, PmGH, Putative uncharacterized protein, RapA, RavR, RbdA, RocR, RpfG, RpfR, ScrG, SO0437, TM0186, TM_0186, VieA, YahA, YcgF, YfgF
ECTree
Inhibitors
Inhibitors on EC 3.1.4.52 - cyclic-guanylate-specific phosphodiesterase
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5'-phosphoguanylyl-(3'-5')-guanosine
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the cyclic di-GMP phosphodiesterase activity of YfgFGE and YfgFE is inhibited by the reaction product
Cu2+
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complete inhibition at 10 mM
GTP
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inhibition of the phosphodiesterase, reduction of tobramycin biofilm stimulation, and suppression of biofilm response, overview
N-(4-hydroxyphenyl)-4-(3-oxo-1,2-benzothiazol-2(3H)-yl)butanamide
compound inhibits Pseudomonas. aeruginosa (PAO1) swarming but not swimming or biofilm formation, it does not inhibit other Pseudomonas aeruginosa phosphodiesterases, such as DipA, PvrR and PA4108
Nalidixic acid
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reduction of tobramycin biofilm stimulation and suppression of biofilm response, overview
additional information
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inhibition of the enzyme leads to suppression of induction of biofilm formation
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Ca2+
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strong
Ca2+
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inhibits both YfgF GGDEF-EAL (YfgFGE) and EAL (YfgFE) domains
Ca2+
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complete inhibition at 10 mM
Ca2+
Ca2+ ions inhibit the phosphodiesterase activity
Zn2+
-
complete inhibition at 10 mM
Zn2+
Zn2+ ions inhibit the phosphodiesterase activity