3.1.4.52: cyclic-guanylate-specific phosphodiesterase
This is an abbreviated version!
For detailed information about cyclic-guanylate-specific phosphodiesterase, go to the full flat file.
Reaction
Synonyms
Arr, BB0374, BCG_1419c, Bd1817, BifA, BinA, Blrp, BlrP1, blue light-regulated phophodiesterase, BpdA, BpdB, c-di-GMP phosphodiesterase, c-di-GMP-hydrolyzing-phosphodiesterase, c-di-GMP-specific PDE, c-di-GMP-specific phosphodiesterase, CC3396, CD0757, CdgC, CdpA, cyclic di-GMP phosphodiesterase, cyclic di-GMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic-di-GMP phosphodiesterase, diguanylate cyclase/phosphodiesterase, Dos, EAL, EAL domain phosphodiesterase, FimX, GAF/HD-GYP protein, H-NOX-associated cyclic-di-GMP processing enzyme, HaCE, HD-GYP, HD-GYP domain cyclic di-GMP phosphodiesterases, HD-GYP domain cyclic dimeric GMP phosphodiesterase, HD-GYP domain cyclic-di-GMP phosphodiesterase, HD-GYP PDE, HD-GYP phosphodiesterase, MbaA, MtbDGC, MtbPDE, PA2567, PA3947, PA4108, PA4367, PA4781, PAS-GGDEF-EAL domain-containing protein, PDE, PDE-A, PdeA, PDEA1, PdeB, PdeC, PdeH, perma_0986, phosphodiesterase A, PmGH, Putative uncharacterized protein, RapA, RavR, RbdA, RocR, RpfG, RpfR, ScrG, SO0437, TM0186, TM_0186, VieA, YahA, YcgF, YfgF
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Reference on EC 3.1.4.52 - cyclic-guanylate-specific phosphodiesterase
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chang, A.L.; Tuckerman, J.R.; Gonzalez, G.; Mayer, R.; Weinhouse, H.; Volman, G.; Amikam, D.; Benziman, M.; Gilles-Gonzalez, M.A.
Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, Is a heme-based sensor
Biochemistry
40
3420-3426
2001
Komagataeibacter xylinus
Schmidt, A.J.; Ryjenkov, D.A.; Gomelsky, M.
The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains
J. Bacteriol.
187
4774-4781
2005
Escherichia coli
Kim, Y.K.; McCarter, L.L.
ScrG, a GGDEF-EAL protein, participates in regulating swarming and sticking in Vibrio parahaemolyticus
J. Bacteriol.
189
4094-4107
2007
Vibrio parahaemolyticus
Lim, B.; Beyhan, S.; Yildiz, F.H.
Regulation of Vibrio polysaccharide synthesis and virulence factor production by CdgC, a GGDEF-EAL domain protein, in Vibrio cholerae
J. Bacteriol.
189
717-729
2007
Vibrio cholerae serotype O1
Kuchma, S.L.; Brothers, K.M.; Merritt, J.H.; Liberati, N.T.; Ausubel, F.M.; O'Toole, G.A.
BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14
J. Bacteriol.
189
8165-8178
2007
Pseudomonas aeruginosa
Christen, M.; Christen, B.; Folcher, M.; Schauerte, A.; Jenal, U.
Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP
J. Biol. Chem.
280
30829-30837
2005
Caulobacter vibrioides
Tamayo, R.; Tischler, A.D.; Camilli, A.
The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase
J. Biol. Chem.
280
33324-33330
2005
Vibrio cholerae serotype O1
Mendez-Ortiz, M.M.; Hyodo, M.; Hayakawa, Y.; Membrillo-Hernandez, J.
Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3', 5'-cyclic diguanylic acid. [Erratum to document cited in CA144:426702]
J. Biol. Chem.
282
22248
2007
Escherichia coli
-
Kazmierczak, B.I.; Lebron, M.B.; Murray, T.S.
Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosa
Mol. Microbiol.
60
1026-1043
2006
Pseudomonas aeruginosa
Andrade, M.O.; Alegria, M.C.; Guzzo, C.R.; Docena, C.; Rosa, M.C.P.; Ramos, C.H.I.; Farah, C.S.
The HD-GYP domain of RpfG mediates a direct linkage between the Rpf quorum-sensing pathway and a subset of diguanylate cyclase proteins in the phytopathogen Xanthomonas axonopodis pv citri
Mol. Microbiol.
62
537-551
2006
Xanthomonas axonopodis
Monds, R.D.; Newell, P.D.; Gross, R.H.; O'Toole, G.A.
Phosphate-dependent modulation of c-di-GMP levels regulates Pseudomonas fluorescens Pf0-1 biofilm formation by controlling secretion of the adhesin LapA
Mol. Microbiol.
63
656-679
2007
Pseudomonas fluorescens, Pseudomonas fluorescens Pf0-1
Rajagopal, S.; Key, J.M.; Purcell, E.B.; Boerema, D.J.; Moffat, K.
Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli
Photochem. Photobiol.
80
542-547
2004
Escherichia coli
Rao, F.; Yang, Y.; Qi, Y.; Liang, Z.X.
Catalytic Mechanism of c-di-GMP specific phosphodiesterase: a study of the EAL domain-containing RocR from Pseudomonas aeruginosa
J. Bacteriol.
190
3622-3631
2008
Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9HX69)
Gotoh, H.; Zhang, Y.; Dallo, S.F.; Hong, S.; Kasaraneni, N.; Weitao, T.
Pseudomonas aeruginosa, under DNA replication inhibition, tends to form biofilms via Arr
Res. Microbiol.
159
294-302
2008
Pseudomonas aeruginosa
Hammer, B.K.; Bassler, B.L.
Distinct sensory pathways in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation
J. Bacteriol.
191
169-177
2009
Vibrio cholerae serotype O1, Vibrio cholerae serotype O1 El Tor C6706
He, Y.W.; Boon, C.; Zhou, L.; Zhang, L.H.
Co-regulation of Xanthomonas campestris virulence by quorum sensing and a novel two-component regulatory system RavS/RavR
Mol. Microbiol.
71
1464-1476
2009
Xanthomonas campestris pv. campestris, Xanthomonas campestris pv. campestris (Q8P947), Xanthomonas campestris pv. campestris (Q8P9A5), Xanthomonas campestris pv. campestris XC1 (Q8P947), Xanthomonas campestris pv. campestris ATCC 33913, Xanthomonas campestris pv. campestris X1 (Q8P9A5)
Tamayo, R.; Schild, S.; Pratt, J.T.; Camilli, A.
Role of cyclic di-GMP during el tor biotype Vibrio cholerae infection: characterization of the in vivo-induced cyclic di-GMP phosphodiesterase CdpA
Infect. Immun.
76
1617-1627
2008
Vibrio cholerae serotype O1
Lee, H.S.; Gu, F.; Ching, S.M.; Lam, Y.; Chua, K.L.
CdpA is a Burkholderia pseudomallei cyclic di-GMP phosphodiesterase involved in autoaggregation, flagellum synthesis, motility, biofilm formation, cell invasion, and cytotoxicity
Infect. Immun.
78
1832-1840
2010
Burkholderia pseudomallei, Burkholderia pseudomallei KHW
Rao, F.; Qi, Y.; Chong, H.S.; Kotaka, M.; Li, B.; Li, J.; Lescar, J.; Tang, K.; Liang, Z.X.
The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase
J. Bacteriol.
191
4722-4731
2009
Pseudomonas aeruginosa
Barends, T.R.; Hartmann, E.; Griese, J.J.; Beitlich, T.; Kirienko, N.V.; Ryjenkov, D.A.; Reinstein, J.; Shoeman, R.L.; Gomelsky, M.; Schlichting, I.
Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase
Nature
459
1015-1018
2009
Klebsiella pneumoniae
An, S.; Wu, J.; Zhang, L.H.
Modulation of Pseudomonas aeruginosa biofilm dispersal by a cyclic-di-GMP phosphodiesterase with a putative hypoxia-sensing domain
Appl. Environ. Microbiol.
76
8160-8173
2010
Pseudomonas aeruginosa
Sultan, S.Z.; Pitzer, J.E.; Boquoi, T.; Hobbs, G.; Miller, M.R.; Motaleb, M.A.
Analysis of the HD-GYP domain cyclic dimeric GMP phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi
Infect. Immun.
79
3273-3283
2011
Borreliella burgdorferi
Bassis, C.M.; Visick, K.L.
The cyclic-di-GMP phosphodiesterase BinA negatively regulates cellulose-containing biofilms in Vibrio fischeri
J. Bacteriol.
192
1269-1278
2010
Aliivibrio fischeri
Petersen, E.; Chaudhuri, P.; Gourley, C.; Harms, J.; Splitter, G.
Brucella melitensis cyclic di-GMP phosphodiesterase BpdA controls expression of flagellar genes
J. Bacteriol.
193
5683-5691
2011
Brucella melitensis
Lovering, A.L.; Capeness, M.J.; Lambert, C.; Hobley, L.; Sockett, R.E.
The structure of an unconventional HD-GYP protein from Bdellovibrio reveals the roles of conserved residues in this class of cyclic-di-GMP phosphodiesterases
mBio
2
e00163
2011
Bdellovibrio bacteriovorus (Q6MM30), Bdellovibrio bacteriovorus
Lacey, M.M.; Partridge, J.D.; Green, J.
Escherichia coli K-12 YfgF is an anaerobic cyclic di-GMP phosphodiesterase with roles in cell surface remodelling and the oxidative stress response
Microbiology
156
2873-2886
2010
Escherichia coli
Bordeleau, E.; Fortier, L.; Malouin, F.; Burrus, V.
c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases
PLoS Genet.
7
e1002039
2011
Clostridioides difficile
Gupta, K.; Kumar, P.; Chatterji, D.
Identification, activity and disulfide connectivity of c-di-GMP regulating proteins in Mycobacterium tuberculosis
PLoS ONE
5
e15072
2010
Mycobacterium tuberculosis
Gao, X.; Dong, X.; Subramanian, S.; Matthews, P.M.; Cooper, C.A.; Kearns, D.B.; Dann, C.E.
Engineering of Bacillus subtilis strains to allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterases
Appl. Environ. Microbiol.
80
6167-6174
2014
Clostridioides difficile, Clostridioides difficile 360
Lahiri, T.; Luan, B.; Raleigh, D.P.; Boon, E.M.
A structural basis for the regulation of an H-NOX-associated cyclic-di-GMP synthase/phosphodiesterase enzyme by nitric oxide-bound H-NOX
Biochemistry
53
2126-2135
2014
Shewanella woodyi
Chao, L.; Rakshe, S.; Leff, M.; Spormann, A.M.
PdeB, a cyclic Di-GMP-specific phosphodiesterase that regulates Shewanella oneidensis MR-1 motility and biofilm formation
J. Bacteriol.
195
3827-3833
2013
Shewanella oneidensis (Q8EJM6), Shewanella oneidensis, Shewanella oneidensis MR-1 / ATCC 700550 (Q8EJM6)
Bellini, D.; Caly, D.L.; McCarthy, Y.; Bumann, M.; An, S.Q.; Dow, J.M.; Ryan, R.P.; Walsh, M.A.
Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre
Mol. Microbiol.
91
26-38
2014
Persephonella marina, Persephonella marina EX-H1
Stelitano, V.; Giardina, G.; Paiardini, A.; Castiglione, N.; Cutruzzola, F.; Rinaldo, S.
C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG
PLoS ONE
8
e74920
2013
Pseudomonas aeruginosa (Q9HV27), Pseudomonas aeruginosa (Q9HWS0), Pseudomonas aeruginosa
Miner, K.D.; Kurtz, D.M.
Active site metal occupancy and cyclic di-GMP phosphodiesterase activity of Thermotoga maritima HD-GYP
Biochemistry
55
970-979
2016
Thermotoga maritima (Q9WY30), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WY30), Thermotoga maritima ATCC 43589 (Q9WY30)
Zheng, Y.; Tsuji, G.; Opoku-Temeng, C.; Sintim, H.O.
Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative
Chem. Sci.
7
6238-6244
2016
Pseudomonas aeruginosa (Q9HX69), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 (Q9HX69)
Herbst, S.; Lorkowski, M.; Sarenko, O.; Nguyen, T.; Jaenicke, T.; Hengge, R.
Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase
EMBO J.
37
e97825
2018
Escherichia coli (P32701)
Jimenez-Fernandez, A.; Lopez-Sanchez, A.; Calero, P.; Govantes, F.
The c-di-GMP phosphodiesterase BifA regulates biofilm development in Pseudomonas putida
Environ. Microbiol. Rep.
7
78-84
2015
Pseudomonas putida, Pseudomonas putida KT2442
Flores-Valdez, M.A.; Aceves-Sanchez, M.d.e. .J.; Pedroza-Roldan, C.; Vega-Dominguez, P.J.; Prado-Montes de Oca, E.; Bravo-Madrigal, J.; Laval, F.; Daffe, M.; Koestler, B.; Waters, C.M.
The cyclic di-GMP phosphodiesterase gene Rv1357c/BCG1419c affects BCG pellicle production and in vivo maintenance
IUBMB Life
67
129-138
2015
Mycobacterium tuberculosis variant bovis (A0A0H3M3N9)
Jung, H.I.; Kim, Y.J.; Lee, Y.J.; Lee, H.S.; Lee, J.K.; Kim, S.K.
Mutation of the cyclic di-GMP phosphodiesterase gene in Burkholderia lata SK875 attenuates virulence and enhances biofilm formation
J. Microbiol.
55
800-808
2017
Burkholderia lata
Aragon, I.; Perez-Mendoza, D.; Gallegos, M.; Ramos, C.
The c-di-GMP phosphodiesterase BifA is involved in the virulence of bacteria from the Pseudomonas syringae complex
Mol. Plant Pathol.
16
604-615
2015
Pseudomonas syringae pv. tomato, Pseudomonas savastanoi pv. savastanoi, Pseudomonas syringae pv. tomato DC3000
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