3.1.4.52: cyclic-guanylate-specific phosphodiesterase

This is an abbreviated version!
For detailed information about cyclic-guanylate-specific phosphodiesterase, go to the full flat file.

Reaction

Synonyms

Arr, BB0374, BCG_1419c, Bd1817, BifA, BinA, Blrp, BlrP1, blue light-regulated phophodiesterase, BpdA, BpdB, c-di-GMP phosphodiesterase, c-di-GMP-hydrolyzing-phosphodiesterase, c-di-GMP-specific PDE, c-di-GMP-specific phosphodiesterase, CC3396, CD0757, CdgC, CdpA, cyclic di-GMP phosphodiesterase, cyclic di-GMP-specific phosphodiesterase, cyclic nucleotide phosphodiesterase, cyclic-di-GMP phosphodiesterase, diguanylate cyclase/phosphodiesterase, Dos, EAL, EAL domain phosphodiesterase, FimX, GAF/HD-GYP protein, H-NOX-associated cyclic-di-GMP processing enzyme, HaCE, HD-GYP, HD-GYP domain cyclic di-GMP phosphodiesterases, HD-GYP domain cyclic dimeric GMP phosphodiesterase, HD-GYP domain cyclic-di-GMP phosphodiesterase, HD-GYP PDE, HD-GYP phosphodiesterase, MbaA, MtbDGC, MtbPDE, PA2567, PA3947, PA4108, PA4367, PA4781, PAS-GGDEF-EAL domain-containing protein, PDE, PDE-A, PdeA, PDEA1, PdeB, PdeC, PdeH, perma_0986, phosphodiesterase A, PmGH, Putative uncharacterized protein, RapA, RavR, RbdA, RocR, RpfG, RpfR, ScrG, SO0437, TM0186, TM_0186, VieA, YahA, YcgF, YfgF

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.52 cyclic-guanylate-specific phosphodiesterase

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Results	in table
5	Activating Compound
21324	AA Sequence
1	CAS Registry Number
28	Cloned(Commentary)
2	Cofactor
4	Crystallization (Commentary)
4	Expression
38	General Information
15	Inhibitors
9	kcat/KM [mM/s]
41	KM Value [mM]
5	Localization
22	Metals/Ions
11	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
65	Organism
30	PDB ID
12	pH Optimum
3	pH Range
1	Posttranslational Modification
115	Protein Variants
16	Purification (Commentary)
2	Reaction
5	Reaction Type
55	Reference
1	Renatured (Commentary)
1	Source Tissue
3	Specific Activity [micromol/min/mg]
53	Substrates and Products (Substrate)
26	Subunits
134	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
48	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.1.4.52 - cyclic-guanylate-specific phosphodiesterase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

3',5'-di-cGMP + H2O

5'-phosphoguanylyl-(3'->5')guanosine

3 entries

5'-phosphoguanylyl-(3'->5')guanosine + H2O

2 5'-GMP

3 entries

c-di-GMP + H2O

?

2 entries

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

6 entries

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'->5')guanosine

4 entries

cyclic di-3',5'-guanylate + H2O

5'phosphoguanylyl(3'-5')guanosine

2 entries

additional information

?

-

8 entries

3',5'-di-cGMP + H2O

5'-phosphoguanylyl-(3'->5')guanosine

Thermotoga maritima

Q9WY30

-

749912

-

-

?

3',5'-di-cGMP + H2O

5'-phosphoguanylyl-(3'->5')guanosine

Thermotoga maritima ATCC 43589

Q9WY30

-

749912

-

-

?

3',5'-di-cGMP + H2O

5'-phosphoguanylyl-(3'->5')guanosine

Thermotoga maritima DSM 3109

Q9WY30

-

749912

-

-

?

5'-phosphoguanylyl-(3'->5')guanosine + H2O

2 5'-GMP

Thermotoga maritima

Q9WY30

-

749912

-

-

?

5'-phosphoguanylyl-(3'->5')guanosine + H2O

2 5'-GMP

Thermotoga maritima ATCC 43589

Q9WY30

-

749912

-

-

?

5'-phosphoguanylyl-(3'->5')guanosine + H2O

2 5'-GMP

Thermotoga maritima DSM 3109

Q9WY30

-

749912

-

-

?

c-di-GMP + H2O

?

Xanthomonas campestris pv. campestris

Q8P947, Q8P9A5

-

700282

-

-

?

c-di-GMP + H2O

?

Xanthomonas campestris pv. campestris XC1

Q8P947

-

700282

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

Borreliella burgdorferi

-

BB0374/PdeB specifically hydrolyzed cyclic di-GMP

715164

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

Clostridioides difficile

-

-

716668

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

Pseudomonas aeruginosa

-

-

713841

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

Pseudomonas aeruginosa

-

degradation

695094

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

Pseudomonas aeruginosa

Q9HX69

RocR, an EAL domain protein that regulates the expression of virulence genes and biofilm formation in Pseudomonas aeruginosa PAO1, catalyzes the hydrolysis of cyclic di-GMP by using a general base-catalyzed mechanism with the assistance of Mg2+ ion

692857

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'-5')guanosine

Vibrio cholerae serotype O1

-

-

703997

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'->5')guanosine

Persephonella marina

-

-

730416

final product is GMP

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'->5')guanosine

Persephonella marina EX-H1

-

-

730416

final product is GMP

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'->5')guanosine

Shewanella oneidensis

Q8EJM6

-

729929

-

-

?

cyclic di-3',5'-guanylate + H2O

5'-phosphoguanylyl(3'->5')guanosine

Shewanella oneidensis MR-1 / ATCC 700550

Q8EJM6

-

729929

-

-

?

cyclic di-3',5'-guanylate + H2O

5'phosphoguanylyl(3'-5')guanosine

Vibrio cholerae serotype O1

-

-

698608

-

-

?

cyclic di-3',5'-guanylate + H2O

5'phosphoguanylyl(3'-5')guanosine

Vibrio cholerae serotype O1 El Tor C6706

-

-

698608

-

-

?

additional information

?

-

Escherichia coli

-

enzyme and cyclic guanylate cyclase YvvD a may be part of a fine-tuning mechanism for regulating the intracellular levels of cyclic diguanylate

680795

-

-

?

additional information

?

-

Escherichia coli

-

enzyme plays a protective role in response to oxidative stress

682265

-

-

?

additional information

?

-

Escherichia coli

-

purified YfgF GGDEF-EAL (YfgFGE) and EAL (YfgFE) domains possess cyclic di-GMP-specific phosphodiesterase activity, but lack diguanylate cyclase activity

716140

-

-

?

additional information

?

-

Mycobacterium tuberculosis

-

Protein Rv 1357c, named as MtbPDE, is an EAL domain protein and degrades cyclic di-GMP to pGpG in vitro. MtbDGC is a bifunctional protein, which can synthesize and degrade cyclic di-GMP in vitro

716686

-

-

?

additional information

?

-

Pseudomonas aeruginosa

-

Arr is required for induction of biofilms under DNA replication stress by a mechanism of stimulated adhesion of planktonic filaments having impaired DNA replication, the induction is suppressed by either inhibition or mutation of the c-di-GMP phosphodiesterase, overview

695094

-

-

?

additional information

?

-

Pseudomonas fluorescens

-

phosphodiesterase RapA is an inhibitor of biofilm formation in response to limiting phosphate supply. Enzyme lowers the levels of cyclic diguanylate which in turn inhibits the secretion of protein LapA required fro biofilm formation

681999

-

-

?

additional information

?

-

Pseudomonas fluorescens Pf0-1

-

phosphodiesterase RapA is an inhibitor of biofilm formation in response to limiting phosphate supply. Enzyme lowers the levels of cyclic diguanylate which in turn inhibits the secretion of protein LapA required fro biofilm formation

681999

-

-

?

additional information

?

-

Vibrio cholerae serotype O1

-

CdgC regulates expression of genes required for Vibrio cholerae polysaccharide synthesis and the transcriptional regulator genes vpsR, vpsT, and hapR. CdgC also regulates expression of genes involved in extracellular protein secretion, flagellar biosynthesis, and virulence factor production. The regulons of CdgC and MbaA overlap, but with different timing

680505

-

-

?