3.1.13.2: exoribonuclease H
This is an abbreviated version!
For detailed information about exoribonuclease H, go to the full flat file.
Word Map on EC 3.1.13.2
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3.1.13.2
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strand
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duplex
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nucleic
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rna-dna
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single-stranded
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integrase
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r-loops
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oligodeoxynucleotides
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retrotransposons
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heteroduplexes
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transcriptases
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phosphorothioate
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retroviruses
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polypurine
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moloney
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phosphodiester
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exonuclease
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rna-dependent
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pre-mrnas
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nucleases
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oligodeoxyribonucleotides
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plus-strand
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nnrti
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template-primer
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nucleocapsids
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minus-strand
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dntp
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spliceosome
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myeloblastosis
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thumb
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endonucleolytic
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oligonucleotide-directed
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2'-o-methylated
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nevirapine
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snrnp
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oligoribonucleotide
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primer-template
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okazaki
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nonnucleoside
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rna-directed
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a-form
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efavirenz
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retroelements
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3'-exonuclease
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heteropolymeric
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phosphoramidite
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pregenomic
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hepadnavirus
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hiv-rt
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pharmacology
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medicine
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drug development
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internucleotide
- 3.1.13.2
- strand
- duplex
- nucleic
- rna-dna
-
single-stranded
-
integrase
-
r-loops
- oligodeoxynucleotides
-
retrotransposons
- heteroduplexes
- transcriptases
- phosphorothioate
- retroviruses
-
polypurine
-
moloney
-
phosphodiester
-
exonuclease
-
rna-dependent
- pre-mrnas
- nucleases
- oligodeoxyribonucleotides
-
plus-strand
-
nnrti
-
template-primer
-
nucleocapsids
-
minus-strand
- dntp
-
spliceosome
-
myeloblastosis
-
thumb
-
endonucleolytic
-
oligonucleotide-directed
-
2'-o-methylated
- nevirapine
-
snrnp
- oligoribonucleotide
-
primer-template
-
okazaki
-
nonnucleoside
-
rna-directed
-
a-form
- efavirenz
-
retroelements
- 3'-exonuclease
-
heteropolymeric
-
phosphoramidite
-
pregenomic
-
hepadnavirus
- hiv-rt
- pharmacology
- medicine
- drug development
-
internucleotide
Reaction
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid =
Synonyms
3'-to-5' RNase H, HIV RNase H, HIV-1 ribonuclease H, HIV-1 RT ribonuclease H, LC11-RNase H1, More, Prp8, retroviral reverse transcriptase RNaseH, retroviral RNase H, reverse transcriptase ribonuclease H, reverse transcriptase-associated ribonuclease H, ribonuclease H, RNase H, RNase H1, RNase HI, RNaseH, RNH, RNH1, RT RNase H, RT/RNase H, T4 RNase H, Ta11
ECTree
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Application
Application on EC 3.1.13.2 - exoribonuclease H
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drug development
medicine
pharmacology
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HIV-1 RNase H is an attractive molecular target for developing anti-HIV agents for potential chemotherapeutic applications
drug development
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HIV-2 RNase H is an attractive molecular target for developing anti-HIV agents for potential chemotherapeutic applications
drug development
the enzyme is a target for anti-HIV drug development
drug development
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development of anti-HIV agents which can be used alone or in the combination with other HIV inhibitors in AIDS chemotherapy
drug development
reverse transcriptase is a primary target for antiretroviral therapy of HIV-1 infected patients. While the vast majority of anti-virals are specific for the polymerase domain, the RNaseH activity of reverse transcriptase represents an excellent target for antiretroviral drugs as well
drug development
reverse transcriptase is a primary target for antiretroviral therapy of HIV-1 infected patients. While the vast majority of anti-virals are specific for the polymerase domain, the RNaseH activity of reverse transcriptase represents an excellent target for antiretroviral drugs as well
drug development
RNase H activity associated with human immunodeficiency virus type 1 is an attractive target for an antiretroviral drug development
drug development
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viruses deficient in RNase H activity are non-infectious making RNase H an interesting target for anti-HIV inhibitors
drug development
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an active recombinant His6-tagged HBV RNaseH is suitable for low-throughput drug screening and can be used to discover enzyme inhibitors, many of which work against viral replication in cells
drug development
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the HBV ribonuclease H (RNaseH) as an antiviral drug target
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the enzyme is a major target for the chemotherapy of human immunodeficiency syndrome, AIDS
medicine
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the enzyme is a major target for the chemotherapy of human immunodeficiency syndrome, AIDS
medicine
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HSV-1 DNA polymerase is a crucial target for antivirals against HSV-1 infection
medicine
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the enzyme is a major target for the chemotherapy of human immunodeficiency syndrome, AIDS
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medicine
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the enzyme is a major target for the chemotherapy of human immunodeficiency syndrome, AIDS
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the enzyme is a target for therapeutic antiviral drug development, design, by combinatorial selection, of dsDNA thioaptamers with selected thiophosphate backbone substitutions inhibiting the RNase activity of the reverse transcriptase and the viral replication, overview
pharmacology
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the enzyme is targeted by drugs via its RNA-DNA hybrid substrates, overview