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3.1.13.2: exoribonuclease H

This is an abbreviated version!
For detailed information about exoribonuclease H, go to the full flat file.

Word Map on EC 3.1.13.2

Reaction

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid =

Synonyms

3'-to-5' RNase H, HIV RNase H, HIV-1 ribonuclease H, HIV-1 RT ribonuclease H, LC11-RNase H1, More, Prp8, retroviral reverse transcriptase RNaseH, retroviral RNase H, reverse transcriptase ribonuclease H, reverse transcriptase-associated ribonuclease H, ribonuclease H, RNase H, RNase H1, RNase HI, RNaseH, RNH, RNH1, RT RNase H, RT/RNase H, T4 RNase H, Ta11

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.13 Exoribonucleases producing 5′-phosphomonoesters
                3.1.13.2 exoribonuclease H

IC50 Value

IC50 Value on EC 3.1.13.2 - exoribonuclease H

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0005
(E)-3,4-dihydroxy-N'-((2-methoxynaphthalen-1-yl)methylene)benzohydrazide
Human immunodeficiency virus 1
-
0.00013 - 0.00024
1,3,4,5-tetragalloylapiitol
0.0095
1,4-Naphthoquinone
Human immunodeficiency virus 1
-
-
0.0374
2,7-dihydroxyisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0353
2-(4-fluorophenyl)-N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.002 - 0.1967
2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
0.00043
2-hydroxy-4H-isoquinoline-1,3-dione
Human Immunodeficiency Virus
-
specific inhibition of isolated RNase H domain and of the full length reverse transcriptase, IC50 value for the isolated RNase H domain is 0.00043 mM
0.1703
2-hydroxy-6-pentadecylbenzoic acid
Human immunodeficiency virus 1
-
-
0.0337
2-hydroxy-6-[(8Z)-pentadec-8-en-1-yl]benzoic acid
Human immunodeficiency virus 1
-
-
0.0072
2-hydroxy-7-(4-hydroxyphenyl)isoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.058
2-hydroxy-7-iodoisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.048
2-hydroxy-7-nitroisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0107
2-hydroxy-7-[4-(trifluoromethyl)phenyl]isoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00043 - 0.0059
2-hydroxyisoquinoline-1,3(2H,4H)-dione
0.0585
2-[(10Z)-heptadec-10-en-1-yl]-6-hydroxybenzoic acid
Human immunodeficiency virus 1
-
-
0.0005
3,4-dihydroxy-N'-[(E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
Human immunodeficiency virus 1
-
IC50 value is about 0.5 microM
0.0075
4'-chloro-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]biphenyl-4-carbohydrazide
Human immunodeficiency virus 1
-
0.00002 - 0.001
4-(1-chloro-1,1-difluoromethyl)-4-(2-phenylethynyl)-6-chloro-2H-3,1-benzoxazin-2-one
0.002
4-(dimethylamino)-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
Human immunodeficiency virus 1
-
0.012
4-methoxy-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
Human immunodeficiency virus 1
-
0.003
4-tert-butyl-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
Human immunodeficiency virus 1
-
0.002 - 0.0035
4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid
Human immunodeficiency virus 1
-
a diketo acid RNase H inhibitor, IC50 values for wild-type and mutant enzymes are 0.002-0.0035 mM with all substrates, effect on mutant enzymes, overview
0.0032 - 0.0047
4-[5-(benzoylamino)tien-2-yl]-2,4-dioxobutanoic acid
0.00038
5-chloro-2-hydroxyisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
inhibits the isolated HIV RNase H domain
0.0038 - 0.0296
5-nitrofuran-2-carboxylic acid adamantan-1-carbamoyl methyl ester
0.0026 - 0.0322
5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydro-furan-2-yl-methyl)-carbamoyl] methyl ester
0.0086
5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydrofuran-2-ylmethyl)-carbamoyl] methyl ester
murine leukemia virus
-
for murine leukemia virus reverse transcriptase
0.0066
7-(3,4-dihydroxyphenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0222
7-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0289
7-chloro-2-hydroxyisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0011 - 0.0015
ardimerin digallate
0.000308 - 0.00047
beta-thujaplicinol
0.002
BPH218
Human immunodeficiency virus 1
-
in vitro IC50 value is about 2 microM
0.0000084 - 0.000091
capravirine
0.0005 - 0.0012
dihydroxy benzoyl naphthyl hydrazone
0.0000045 - 0.0000637
efavirenz
0.013
ethyl (5E)-6-[1-(4-fluorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoate
Human immunodeficiency virus 1
-
-
0.0000076 - 0.0000238
GW8248
0.00146
hyemaloside A
Human immunodeficiency virus 1
-
-
0.00119
hyemaloside C
Human immunodeficiency virus 1
-
-
0.05
illimaquinone
Human immunodeficiency virus 1
-
-
0.015
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]-4-methylbenzohydrazide
Human immunodeficiency virus 1
-
0.007
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]-4-phenoxybenzohydrazide
Human immunodeficiency virus 1
-
0.015
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
Human immunodeficiency virus 1
-
0.005
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]biphenyl-4-carbohydrazide
Human immunodeficiency virus 1
-
0.0108
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-nitrobenzamide
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0071
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-fluorobenzamide
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0407
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0057
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.003
N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone
Human immunodeficiency virus 1
-
IC50 is about 3 microM
0.0032 - 0.005
N-[3-(aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-furancarboxamide
0.000216 - 0.01
nevirapine
0.025
Phosphonoformate
Human immunodeficiency virus 1
-
the inhibitor that bind in the reverse transcriptase polymerase domain inhibits also RNase H activity, IC value for the wild-type enzyme is 0.0015 mM versus substrate DNA-18-nucleotide-RNA hybrid, with the other substrates the IC50 value is above 0.025 mM
0.0000471 - 0.000147
TMC-125
additional information
additional information
-