Application | Comment | Organism |
---|---|---|
drug development | HIV-1 RNase H is an attractive molecular target for developing anti-HIV agents for potential chemotherapeutic applications | Human immunodeficiency virus 1 |
drug development | HIV-2 RNase H is an attractive molecular target for developing anti-HIV agents for potential chemotherapeutic applications | Human immunodeficiency virus 2 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3,4,5-tetragalloylapiitol | isolated from the aqueous extract of leaves of the plant Hylodendron gabunensis | Human immunodeficiency virus 1 | |
1,3,4,5-tetragalloylapiitol | isolated from the aqueous extract of leaves of the plant Hylodendron gabunensis | Human immunodeficiency virus 2 | |
additional information | natural product extracts screening for detection of inhibitors specific for HIV-1 RNase H | Human immunodeficiency virus 1 | |
additional information | natural product extracts screening for detection of inhibitors specific for HIV-2 RNase H | Human immunodeficiency virus 2 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Human immunodeficiency virus 1 | the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome | ? | - |
? | |
additional information | Human immunodeficiency virus 2 | the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
i.e. HIV-1 | - |
Human immunodeficiency virus 2 | - |
i.e. HIV-2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-RNA hybrid + H2O | RNase H specifically hydrolyzes the RNA strand of a RNA/DNA heteroduplex, the ribonuclease H hydrolytic activity is part of the reverse transcriptase | Human immunodeficiency virus 1 | ? | - |
? | |
DNA-RNA hybrid + H2O | RNase H specifically hydrolyzes the RNA strand of a RNA/DNA heteroduplex, the ribonuclease H hydrolytic activity is part of the reverse transcriptase | Human immunodeficiency virus 2 | ? | - |
? | |
additional information | the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome | Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome | Human immunodeficiency virus 2 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNase H | - |
Human immunodeficiency virus 1 |
RNase H | - |
Human immunodeficiency virus 2 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Human immunodeficiency virus 1 |
25 | - |
assay at | Human immunodeficiency virus 2 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00013 | - |
25°C | Human immunodeficiency virus 2 | 1,3,4,5-tetragalloylapiitol | |
0.00024 | - |
25°C | Human immunodeficiency virus 1 | 1,3,4,5-tetragalloylapiitol |