Reference on EC 3.1.13.2 - exoribonuclease H
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Leis, J.P.; Berkower, I.; Hurwitz, J.
Mechanism of action of ribonuclease H isolated from avian myeloblastosis virus and Escherichia coli
Proc. Natl. Acad. Sci. USA
70
466-470
1973
Avian myeloblastosis virus, More
Verma, I.M.
Studies on reverse transcriptase of RNA tumor viruses III. Properties of purified Moloney murine leukemia virus DNA polymerase and associated RNase H
J. Virol.
15
843-854
1975
Moloney murine leukemia virus, Moloney murine leukemia virus M-MuLV, More
Grandgenett, D.P.; Gerard, G.F.; Green, M.
Ribonuclease H: a ubiquitous activity in virions of ribonucleic acid tumor viruses
J. Virol.
10
1136-1142
1972
Avian myeloblastosis virus, feline leukemia virus, Harvey murine sarcoma virus, Mason-Pfizer monkey virus, Moloney murine leukemia virus, More, Rauscher leukemia virus, RD-feline leukemia virus, Rous sarcoma virus, Harvey murine sarcoma virus MSV-MLV(H)
Modak, M.J.; Srivastava, A.
Reverse transcriptase-associated ribonuclease H does not require zinc for catalysis
J. Biol. Chem.
254
4756-4759
1979
Avian myeloblastosis virus, Mason-Pfizer monkey virus, More, mouse mammary tumor virus, Rauscher leukemia virus, Woolly monkey sarcoma virus
Kleinicke, C.; Fischer, H.; Flugel.R.M.
Ribonuclease H activities associated with Herpes simplex virus
Biochem. Biophys. Res. Commun.
60
1491-1498
1974
Herpes simplex virus, Herpes simplex virus HSV
Keller, W.; Crouch, R.
Degradation of DNA RNA hybrids by ribonuclease H and DNA polymerases of cellular and viral origin
Proc. Natl. Acad. Sci. USA
69
3360-3364
1972
Avian myeloblastosis virus, More, Rous-associated virus
Stammers, D.K.; Tisdale, M.; Court, S.; Parmar, V.; Bradley, C.; Ross, C.K.
Rapid purification and characterization of HIV-1 reverse transcriptase and RNaseH engineered to incorporate a C-terminal tripeptide alpha-tubulin epitope
FEBS Lett.
283
298-302
1991
Human immunodeficiency virus 1, More
Wei, X.; Peterson, D.L.
Expression, purification and characterization of an active RNase H domain of the Hepatitis B viral polymerase
J. Biol. Chem.
271
32617-32622
1996
Hepatitis B virus, More, Hepatitis B virus HBV
Zhan, X.; Tan, C.K.; Scott, W.A.; Mian, A.M.; Downey, K.M.; So, A.G.
Catalytically distinct conformations of the ribonuclease H of HIV-1 reverse transcriptase by substrate cleavage patterns and inhibition by azidothymidylate and N-ethylmaleimide
Biochemistry
33
1366-1372
1994
Human immunodeficiency virus 1
Cristofaro, J.V.; Rausch, J.W.; Le Grice, S.F.J.; DeStefano, J.J.
Mutations in the ribonuclease H active site of HIV-RT reveal a role for this site in stabilizing enzyme-primer-template binding
Biochemistry
41
10968-10975
2002
Human Immunodeficiency Virus, Human Immunodeficiency Virus HXB2
Pari, K.; Mueller, G.A.; DeRose, E.F.; Kirby, T.W.; London, R.E.
Solution structure of the RNase H domain of the HIV-1 reverse transcriptase in the presence of magnesium
Biochemistry
42
639-650
2003
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Guaitiao, J.P.; Zuniga, R.A.; Roth, M.J.; Leon, O.
Lysine directed cross-linking of viral DNA-RNA:DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase
Biochemistry
43
1302-1308
2004
Human immunodeficiency virus 1
Arion, D.; Sluis-Cremer, N.; Min, K.L.; Abram, M.E.; Fletcher, R.S.; Parniak, M.A.
Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase: effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones
J. Biol. Chem.
277
1370-1374
2002
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Lener, D.; Budihas, S.R.; Le Grice, S.F.J.
Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events
J. Biol. Chem.
277
26486-26495
2002
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Roda, R.H.; Balakrishnan, M.; Hanson, M.N.; Woehrl, B.M.; Le Grice, S.F.J.; Roques, B.P.; Gorelick, R.J.; Bambara, R.A.
Role of the reverse transcriptase, nucleocapsid protein, and template structure in the two-step transfer mechanism in retroviral recombination
J. Biol. Chem.
278
31536-31546
2003
equine infectious anemia virus, Human immunodeficiency virus 1, equine infectious anemia virus EIAV
Sevilya, Z.; Loya, S.; Hughes, S.H.; Hizi, A.
The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is affected by the thumb subdomain of the small protein subunits
J. Mol. Biol.
311
957-971
2001
Human immunodeficiency virus 1, Human immunodeficiency virus 2
Sevilya, Z.; Loya, S.; Duvshani, A.; Adir, N.; Hizi, A.
Mutagenesis of cysteine 280 of the reverse transcriptase of human immunodeficiency virus type-1: The effects on the ribonuclease H activity
J. Mol. Biol.
327
19-30
2003
Human immunodeficiency virus 1
Julias, J.G.; McWilliams, M.J.; Sarafianos, S.G.; Alvord, W.G.; Arnold, E.; Hughes, S.H.
Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity
J. Virol.
77
8548-8554
2003
Human immunodeficiency virus 1
Wisniewski, M.; Balakrishnan, M.; Palaniappan, C.; Fay, P.J.; Bambara, R.A.
Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H
Proc. Natl. Acad. Sci. USA
97
11978-11983
2000
Human immunodeficiency virus 1
Boyer, P.L.; Stenbak, C.R.; Clark, P.K.; Linial, M.L.; Hughes, S.H.
Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase
J. Virol.
78
6112-6121
2004
human foamy virus
Nakayama, G.R.; Bingham, P.; Tan, D.; Maegley, K.A.
A fluorescence polarization assay for screening inhibitors against the ribonuclease H activity of HIV-1 reverse transcriptase
Anal. Biochem.
351
260-265
2006
Human immunodeficiency virus 1
Didierjean, J.; Isel, C.; Querre, F.; Mouscadet, J.F.; Aubertin, A.M.; Valnot, J.Y.; Piettre, S.R.; Marquet, R.
Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones
Antimicrob. Agents Chemother.
49
4884-4894
2005
Human immunodeficiency virus 1
Hang, J.Q.; Rajendran, S.; Yang, Y.; Li, Y.; In, P.W.K.; Overton, H.; Parkes, K.E.B.; Cammack, N.; Martin, J.A.; Klumpp, K.
Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides
Biochem. Biophys. Res. Commun.
317
321-329
2004
Human Immunodeficiency Virus
Mueller, G.A.; Pari, K.; DeRose, E.F.; Kirby, T.W.; London, R.E.
Backbone dynamics of the RNase H domain of HIV-1 reverse transcriptase
Biochemistry
43
9332-9342
2004
Human immunodeficiency virus 1
Li, T.K.; Barbieri, C.M.; Lin, H.C.; Rabson, A.B.; Yang, G.; Fan, Y.; Gaffney, B.L.; Jones, R.A.; Pilch, D.S.
Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication
Biochemistry
43
9732-9742
2004
Human immunodeficiency virus 1
Somasunderam, A.; Ferguson, M.R.; Rojo, D.R.; Thiviyanathan, V.; Li, X.; O'Brien, W.A.; Gorenstein, D.G.
Combinatorial selection, inhibition, and antiviral activity of DNA thioaptamers targeting the RNase H domain of HIV-1 reverse transcriptase
Biochemistry
44
10388-10395
2005
Human immunodeficiency virus 1
Shaw-Reid, C.A.; Feuston, B.; Munshi, V.; Getty, K.; Krueger, J.; Hazuda, D.J.; Parniak, M.A.; Miller, M.D.; Lewis, D.
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities
Biochemistry
44
1595-1606
2005
Human immunodeficiency virus 1
Purohit, V.; Balakrishnan, M.; Kim, B.; Bambara, R.A.
Evidence that HIV-1 reverse transcriptase employs the DNA 3' end-directed primary/secondary RNase H cleavage mechanism during synthesis and strand transfer
J. Biol. Chem.
280
40534-40543
2005
Human immunodeficiency virus 1
Schultz, S.J.; Zhang, M.; Champoux, J.J.
Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H
J. Biol. Chem.
281
1943-1955
2006
Human immunodeficiency virus 1, Moloney murine leukemia virus
Schultz, S.J.; Zhang, M.; Champoux, J.J.
Recognition of internal cleavage sites by retroviral RNases H
J. Mol. Biol.
344
635-652
2004
Human immunodeficiency virus 1, Moloney murine leukemia virus
Mbisa, J.L.; Nikolenko, G.N.; Pathak, V.K.
Mutations in the RNase H primer grip domain of murine leukemia virus reverse transcriptase decrease efficiency and accuracy of plus-strand DNA transfer
J. Virol.
79
419-427
2005
murine leukemia virus
Budihas, S.R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M.K.; Parniak, M.A.; Crouch, R.J.; McMahon, J.B.; Beutler, J.A.; Le Grice, S.F.J.
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
Nucleic Acids Res.
33
1249-1256
2005
Human Immunodeficiency Virus
Hang, J.Q.; Li, Y.; Yang, Y.; Cammack, N.; Mirzadegan, T.; Klumpp, K.
Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Biochem. Biophys. Res. Commun.
352
341-350
2007
Human immunodeficiency virus 1
Himmel, D.M.; Sarafianos, S.G.; Dharmasena, S.; Hossain, M.M.; McCoy-Simandle, K.; Ilina, T.; Clark, A.D.; Knight, J.L.; Julias, J.G.; Clark, P.K.; Krogh-Jespersen, K.; Levy, R.M.; Hughes, S.H.; Parniak, M.A.; Arnold, E.
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
ACS Chem. Biol.
1
702-712
2006
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Kissel, J.D.; Held, D.M.; Hardy, R.W.; Burke, D.H.
Single-stranded DNA aptamer RT1t49 inhibits RT polymerase and RNase H functions of HIV type 1, HIV type 2, and SIVCPZ RTs
AIDS Res. Hum. Retroviruses
23
699-708
2007
Human immunodeficiency virus 1, Human immunodeficiency virus 2, Simian immunodeficiency virus
Marchand, C.; Beutler, J.A.; Wamiru, A.; Budihas, S.; Moellmann, U.; Heinisch, L.; Mellors, J.W.; Le Grice, S.F.; Pommier, Y.
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H
Antimicrob. Agents Chemother.
52
361-364
2008
Human immunodeficiency virus 1
Purohit, V.; Roques, B.P.; Kim, B.; Bambara, R.A.
Mechanisms that prevent template inactivation by HIV-1 reverse transcriptase RNase H cleavages
J. Biol. Chem.
282
12598-12609
2007
Human immunodeficiency virus 1
Takada, K.; Bermingham, A.; OKeefe, B.R.; Wamiru, A.; Beutler, J.A.; Le Grice, S.F.; Lloyd, J.; Gustafson, K.R.; McMahon, J.B.
An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis
J. Nat. Prod.
70
1647-1649
2007
Human immunodeficiency virus 1, Human immunodeficiency virus 2
Dat, N.T.; Bae, K.; Wamiru, A.; McMahon, J.B.; Le Grice, S.F.; Bona, M.; Beutler, J.A.; Kim, Y.H.
A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H
J. Nat. Prod.
70
839-841
2007
Human immunodeficiency virus 1, Human immunodeficiency virus 2
Lim, D.; Gregorio, G.G.; Bingman, C.; Martinez-Hackert, E.; Hendrickson, W.A.; Goff, S.P.
Crystal structure of the moloney murine leukemia virus RNase H domain
J. Virol.
80
8379-8389
2006
Moloney murine leukemia virus
Wang, J.; Dykes, C.; Domaoal, R.A.; Koval, C.E.; Bambara, R.A.; Demeter, L.M.
The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNALys,3 that correlate with reductions in replication effciciency
Virology
348
462-474
2006
Human immunodeficiency virus 1
Schultz, S.J.; Champoux, J.J.
RNase H activity: structure, specificity, and function in reverse transcription
Virus Res.
134
86-103
2008
Moloney murine leukemia virus, Moloney murine leukemia virus (P03355), Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Wendeler, M.; Lee, H.F.; Bermingham, A.; Miller, J.T.; Chertov, O.; Bona, M.K.; Baichoo, N.S.; Ehteshami, M.; Beutler, J.; OKeefe, B.R.; Goette, M.; Kvaratskhelia, M.; Le Grice, S.
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity
ACS Chem. Biol.
3
635-644
2008
Human immunodeficiency virus 1, Human immunodeficiency virus 2
Heinrich, J.; Mathur, S.; Matskevich, A.A.; Moelling, K.
Oligonucleotide-mediated retroviral RNase H activation leads to reduced HIV-1 titer in patient-derived plasma
AIDS
23
213-221
2009
Human immunodeficiency virus 1
Ehteshami, M.; Goette, M.
Effects of mutations in the connection and RNase H domains of HIV-1 reverse transcriptase on drug susceptibility
AIDS Rev.
10
224-235
2008
Human immunodeficiency virus 1
Updegrove, T.; Wilf, N.; Sun, X.; Wartell, R.M.
Effect of Hfq on RprA-rpoS mRNA pairing: Hfq-RNA binding and the influence of the 5 rpoS mRNA leader region
Biochemistry
47
11184-11195
2008
Escherichia coli
Pena, V.; Rozov, A.; Fabrizio, P.; Luehrmann, R.; Wahl, M.C.
Structure and function of an RNase H domain at the heart of the spliceosome
EMBO J.
27
2929-2940
2008
Saccharomyces cerevisiae (P33334), Saccharomyces cerevisiae
Champoux, J.J.; Schultz, S.J.
Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription
FEBS J.
276
1506-1516
2009
Moloney murine leukemia virus, Avian sarcoma leukosis virus, Human immunodeficiency virus 1 (P03366)
Bochner, R.; Duvshani, A.; Adir, N.; Hizi, A.
Mutagenesis of Gln294 of the reverse transcriptase of human immunodeficiency virus type-2 and its effects on the ribonuclease H activity
FEBS Lett.
582
2799-2805
2008
Human immunodeficiency virus 1, Human immunodeficiency virus 2
Roquebert, B.; Marcelin, A.G.
The involvement of HIV-1 RNAse H in resistance to nucleoside analogues
J. Antimicrob. Chemother.
61
973-975
2008
Human immunodeficiency virus 1
Yasukawa, K.; Mizuno, M.; Inouye, K.
Characterization of Moloney murine leukaemia virus/avian myeloblastosis virus chimeric reverse transcriptases
J. Biochem.
145
315-324
2009
Avian myeloblastosis virus, Moloney murine leukemia virus (P03355), Moloney murine leukemia virus
Ehteshami, M.; Beilhartz, G.L.; Scarth, B.J.; Tchesnokov, E.P.; McCormick, S.; Wynhoven, B.; Harrigan, P.R.; Goette, M.
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3-azido-3-deoxythymidine through both RNase H-dependent and -independent mechanisms
J. Biol. Chem.
283
22222-22232
2008
Human immunodeficiency virus 1
Billamboz, M.; Bailly, F.; Barreca, M.L.; De Luca, L.; Mouscadet, J.F.; Calmels, C.; Andreola, M.L.; Witvrouw, M.; Christ, F.; Debyser, Z.; Cotelle, P.
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain
J. Med. Chem.
51
7717-7730
2008
Human immunodeficiency virus 1
Fuji, H.; Urano, E.; Futahashi, Y.; Hamatake, M.; Tatsumi, J.; Hoshino, T.; Morikawa, Y.; Yamamoto, N.; Komano, J.
Derivatives of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase
J. Med. Chem.
52
1380-1387
2009
murine leukemia virus
Sarafianos, S.G.; Marchand, B.; Das, K.; Himmel, D.M.; Parniak, M.A.; Hughes, S.H.; Arnold, E.
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
J. Mol. Biol.
385
693-713
2009
Human immunodeficiency virus 1
Rigby, S.T.; Rose, A.E.; Hanson, M.N.; Bambara, R.A.
Mechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genome
J. Mol. Biol.
388
30-47
2009
Human immunodeficiency virus 1
Beilhartz, G.L.; Wendeler, M.; Baichoo, N.; Rausch, J.; Le Grice, S.; Goette, M.
HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition
J. Mol. Biol.
388
462-474
2009
Human immunodeficiency virus 1
Bokesch, H.R.; Wamiru, A.; Le Grice, S.F.; Beutler, J.A.; McKee, T.C.; McMahon, J.B.
HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis
J. Nat. Prod.
71
1634-1636
2008
Human immunodeficiency virus 1
Yu, F.; Liu, X.; Zhan, P.; De Clercq, E.
Recent advances in the research of HIV-1 RNase H inhibitors
Mini Rev. Med. Chem.
8
1243-1251
2008
Human immunodeficiency virus 1
Dash, C.; Scarth, B.J.; Badorrek, C.; Goette, M.; Le Grice, S.F.
Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids
Nucleic Acids Res.
36
6363-6371
2008
Human immunodeficiency virus 1
Li, N.; Wang, Y.; Pothukuchy, A.; Syrett, A.; Husain, N.; Gopalakrisha, S.; Kosaraju, P.; Ellington, A.D.
Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
Nucleic Acids Res.
36
6739-6751
2008
Human immunodeficiency virus 1 (P03366), Human immunodeficiency virus 1
Post, K.; Kankia, B.; Gopalakrishnan, S.; Yang, V.; Cramer, E.; Saladores, P.; Gorelick, R.J.; Guo, J.; Musier-Forsyth, K.; Levin, J.G.
Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein
Nucleic Acids Res.
37
1755-1766
2009
Human immunodeficiency virus 1
Lee, J.S.; Hattori, M.; Kim, J.
Inhibition of HIV-1 protease and RNase H of HIV-1 reverse transcriptase activities by long chain phenols from the sarcotestas of Ginkgo biloba
Planta Med.
74
532-534
2008
Human immunodeficiency virus 1
Santos, A.F.; Lengruber, R.B.; Soares, E.A.; Jere, A.; Sprinz, E.; Martinez, A.M.; Silveira, J.; Sion, F.S.; Pathak, V.K.; Soares, M.A.
Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients
PLoS ONE
3
e1781
2008
Human immunodeficiency virus 1
Abdur, R.; Gerlits, O.O.; Gan, J.; Jiang, J.; Salon, J.; Kovalevsky, A.Y.; Chumanevich, A.A.; Weber, I.T.; Huang, Z.
Novel complex MAD phasing and RNase H structural insights using selenium oligonucleotides
Acta Crystallogr. Sect. D
70
354-361
2014
Halalkalibacterium halodurans (Q9KEI9), Halalkalibacterium halodurans DSM 18197 (Q9KEI9)
Kirby, K.A.; Marchand, B.; Ong, Y.T.; Ndongwe, T.P.; Hachiya, A.; Michailidis, E.; Leslie, M.D.; Sietsema, D.V.; Fetterly, T.L.; Dorst, C.A.; Singh, K.; Wang, Z.; Parniak, M.A.; Sarafianos, S.G.
Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase
Antimicrob. Agents Chemother.
56
2048-2061
2012
Human immunodeficiency virus 1, Moloney murine leukemia virus, Xenotropic MuLV-related virus (A1Z651), Xenotropic MuLV-related virus
Alla, N.R.; Nicholson, A.W.
Evidence for a dual functional role of a conserved histidine in RNA-DNA heteroduplex cleavage by human RNase H1
FEBS J.
279
4492-4500
2012
Homo sapiens
Tannous, E.; Yokoyama, K.; You, D.J.; Koga, Y.; Kanaya, S.
A dual role of divalent metal ions in catalysis and folding of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1
FEBS Open Bio
2
345-352
2012
Halobacterium sp., Halobacterium sp. NRC-1
Stafford, K.A.; Ferrage, F.; Cho, J.H.; Palmer, A.G.
Side chain dynamics of carboxyl and carbonyl groups in the catalytic function of Escherichia coli ribonuclease H
J. Am. Chem. Soc.
135
18024-18027
2013
Escherichia coli
Babu, C.S.; Dudev, T.; Lim, C.
Differential role of the protein matrix on the binding of a catalytic aspartate to Mg2+ vs Ca2+: application to ribonuclease H
J. Am. Chem. Soc.
135
6541-6548
2013
Escherichia coli, Moloney murine leukemia virus (P03355)
Rosen, L.E.; Kathuria, S.V.; Matthews, C.R.; Bilsel, O.; Marqusee, S.
Non-native structure appears in microseconds during the folding of E. coli RNase H
J. Mol. Biol.
427
443-453
2015
Escherichia coli (P0A7Y4), Escherichia coli
Zhou, D.; Chung, S.; Miller, M.; Grice, S.F.; Wlodawer, A.
Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus
J. Struct. Biol.
177
638-645
2012
Xenotropic MuLV-related virus (A1Z651), Xenotropic MuLV-related virus
Ko, C.; Shin, Y.C.; Park, W.J.; Kim, S.; Kim, J.; Ryu, W.S.
Residues Arg703, Asp777, and Arg781 of the RNase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis
J. Virol.
88
154-163
2014
Hepatitis B virus
Hayer, J.; Rodriguez, C.; Germanidis, G.; Deleage, G.; Zoulim, F.; Pawlotsky, J.M.; Combet, C.
Ultradeep pyrosequencing and molecular modeling identify key structural features of hepatitis B virus RNase H, a putative target for antiviral intervention
J. Virol.
88
574-582
2014
Hepatitis B virus
Sipova, H.; Springer, T.; Rejman, D.; Simak, O.; Petrova, M.; Novak, P.; Rosenbergova, S.; Pav, O.; Liboska, R.; Barvik, I.; Stepanek, J.; Rosenberg, I.; Homola, J.
5'-O-Methylphosphonate nucleic acids--new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes
Nucleic Acids Res.
42
5378-5389
2014
Escherichia coli
Tannous, E.; Kanaya, S.
Divalent metal ion-induced folding mechanism of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1
PLoS ONE
9
e109016
2014
Halobacterium sp. (Q9HSF6), Halobacterium sp., Halobacterium sp. NRC-1 (Q9HSF6)
Smyshlyaev, G.; Voigt, F.; Blinov, A.; Barabas, O.; Novikova, O.
Acquisition of an Archaea-like ribonuclease H domain by plant L1 retrotransposons supports modular evolution
Proc. Natl. Acad. Sci. USA
110
20140-20145
2013
Arabidopsis thaliana
Nguyen, T.N.; Angkawidjaja, C.; Kanaya, E.; Koga, Y.; Takano, K.; Kanaya, S.
Activity, stability, and structure of metagenome-derived LC11-RNase H1, a homolog of Sulfolobus tokodaii RNase H1
Protein Sci.
21
553-561
2012
Sulfurisphaera tokodaii (F9VN79), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 (F9VN79)
Leo, B.; Hartl, M.J.; Schweimer, K.; Mayr, F.; Woehrl, B.M.
Insights into the structure and activity of prototype foamy virus RNase H
Retrovirology
9
14
2012
Human spumaretrovirus
Leo, B.; Schweimer, K.; Roesch, P.; Hartl, M.J.; Woehrl, B.M.
The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding
Retrovirology
9
73
2012
Human spumaretrovirus (P14350)
Villa, J.A.; Pike, D.P.; Patel, K.B.; Lomonosova, E.; Lu, G.; Abdulqader, R.; Tavis, J.E.
Purification and enzymatic characterization of the hepatitis B virus ribonuclease H, a new target for antiviral inhibitors
Antiviral Res.
132
186-195
2016
Hepatitis B virus
Edwards, T.C.; Mani, N.; Dorsey, B.; Kakarla, R.; Rijnbrand, R.; Sofia, M.J.; Tavis, J.E.
Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors
Antiviral Res.
164
70-80
2019
Hepatitis B virus
Lawler, J.L.; Mukherjee, P.; Coen, D.M.
Herpes simplex virus 1 DNA polymerase RNase H activity acts in a 3'-to-5' direction and is dependent on the 3'-to-5' exonuclease active site
J. Virol.
92
e01813-17
2018
Human alphaherpesvirus 1
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