Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.13.2: exoribonuclease H

This is an abbreviated version!
For detailed information about exoribonuclease H, go to the full flat file.

Word Map on EC 3.1.13.2

Reaction

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid =

Synonyms

3'-to-5' RNase H, HIV RNase H, HIV-1 ribonuclease H, HIV-1 RT ribonuclease H, LC11-RNase H1, More, Prp8, retroviral reverse transcriptase RNaseH, retroviral RNase H, reverse transcriptase ribonuclease H, reverse transcriptase-associated ribonuclease H, ribonuclease H, RNase H, RNase H1, RNase HI, RNaseH, RNH, RNH1, RT RNase H, RT/RNase H, T4 RNase H, Ta11

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.13 Exoribonucleases producing 5′-phosphomonoesters
                3.1.13.2 exoribonuclease H

Inhibitors

Inhibitors on EC 3.1.13.2 - exoribonuclease H

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)acetic acid
-
-
(2E)-2-[(4-chlorophenyl)hydrazono]propanoic acid
-
4-chlorophenylhydrazone of pyruvic acid, shows poor inhibitory activity against HIV-1 RNase H because of the storage of one or two carboxylic acid moieties
(2Z)-2-hydroxy-4-oxopent-2-enoic acid
-
-
(E)-3,4-dihydroxy-N'-((2-methoxynaphthalen-1-yl)methylene)benzohydrazide
i.e. DHBNH, highly specific, noncompetitive, binding site analysis, the inhibitor binds near both the polymerase active site and the non-nucleoside reverse transcriptase inhibitor binding pocket, it specifically interacts with conserved residues Asp186 and Trp229 and has substantial interactions with the backbones of several less well-conserved residues, overview, substituted inhibitor derivatives, that interact with the nucleoside analog RT inhibitor-binding pocket, inhibit both the polymerase and RNH activities of reverse transcriptase, DHBNH interacts with other residues, including Val108, Leu187, Tyr188, Lys223, Phe227, and Leu228
1,3,4,5-tetragalloylapiitol
1,4-Naphthoquinone
-
-
1,6-dihydroxy-4-methyl-5-(N-phenoxyethanimidoyl)pyridin-2(1H)-one
-
-
1,6-dihydroxy-4-methyl-5-[N-[(4-methylphenyl)methoxy]ethanimidoyl]pyridin-2(1H)-one
-
-
1,6-dihydroxy-5-[N-[(2-methoxyphenyl)methoxy]ethanimidoyl]-4-methylpyridin-2(1H)-one
-
-
1,6-dihydroxy-5-[N-[(4-methoxyphenyl)methoxy]ethanimidoyl]-4-methylpyridin-2(1H)-one
-
-
1,9,11,14-tetrahydroxy-3-[(E)-{[(2-hydroxyphenyl)carbonyl]hydrazono}methyl]-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-3-[(E)-{[(4-methylphenyl)sulfonyl]hydrazono}methyl]-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-3-{(E)-[(4-nitrophenyl)hydrazono]methyl}-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-3-(1,2,3,4-tetrahydroquinazolin-2-yl)-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-3-[(E)-(tetracyclo[5.3.1.03,9.05,9]undec-1-ylimino)methyl]-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-3-{(E)-[(phenylcarbonyl)hydrazono]methyl}-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2,3-dicarboxylic acid
-
-
1,9,11,14-tetrahydroxy-7-methoxy-3-[(E)-(methoxyimino)methyl]-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
1-(4-chlorophenyl)-2-(1-methylethylidene)hydrazine
-
4-chlorophenylhydrazone of acetone, shows poor inhibitory activity against HIV-1 RNase H because of the storage of one or two carboxylic acid moieties
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazine-2(1H)-carboximidamide
-
-
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-2,3,4,4a,6,7-hexahydropyrimido[2,1-a]tetraceno[1,2-f]isoindole-9,14,17(1H)-trione
-
-
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-2-phenyl-6,7-dihydrotetraceno[1,2-g]phthalazine-1,9,14(2H)-trione
-
-
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-2-propyl-6,7-dihydrotetraceno[1,2-g]phthalazine-1,9,14(2H)-trione
-
-
10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-6,7-dihydrotetraceno[1,2-g]phthalazine-1,9,14(2H)-trione
-
-
12,14,17,18-tetrahydroxy-10-methoxy-13-methyl-6,6a,8,9-tetrahydrotetraceno[1',2':5,6]isoindolo[2,1-a]quinazoline-11,16,19(5H)-trione
-
-
15,16-dihydroxy-8-methoxy-12-[(methoxycarbonyl)oxy]-11-methyl-1,9,14-trioxo-2-propyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazin-10-yl acetate
-
-
2'-deoxy-4'-ethyl-3,4-dihydrothymidine
-
-
2'-deoxy-4'-ethynyl-2-fluoroadenosine
-
-
2'-deoxy-4'-methyl-3,4-dihydrothymidine
-
-
2,4,17,18-tetrahydroxy-6-methoxy-3-methyl-7,9b-dihydrotetraceno[1',2':5,6]isoindolo[1,2-b][1,3]benzothiazole-5,16,19(8H)-trione
-
-
2,7-dihydroxy-4-isopropylcyclohepta-2,4,6-trienone
2,7-dihydroxyisoquinoline-1,3(2H,4H)-dione
-
-
2-(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)ethyl acetate
-
-
2-(4-fluorophenyl)-N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide
-
-
2-amino-12-ethyl-7-(1-hydroxypropyl)-8-methylindolizino[1,2-b]quinolin-9(11H)-one
-
mappicine analogue
2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
2-aminoisoquinoline-1,3(2H,4H)-dione
-
-
2-chloro-7-(2-cyclohexyl-1-hydroxyethyl)-8-methyl-12-propylindolizino[1,2-b]quinolin-9(11H)-one
-
mappicine analogue
2-hydroxy-4H-isoquinoline-1,3-dione
-
specific inhibition of isolated RNase H domain and of the full length reverse transcriptase, IC50 value for the isolated RNase H domain is 0.00043 mM
2-hydroxy-6-pentadecylbenzoic acid
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
2-hydroxy-6-[(8Z)-pentadec-8-en-1-yl]benzoic acid
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
2-hydroxy-7-(4-hydroxyphenyl)isoquinoline-1,3(2H,4H)-dione
-
-
2-hydroxy-7-iodoisoquinoline-1,3(2H,4H)-dione
-
-
2-hydroxy-7-nitroisoquinoline-1,3(2H,4H)-dione
-
-
2-hydroxy-7-phenylisoquinoline-1,3(2H,4H)-dione
-
-
2-hydroxy-7-[4-(trifluoromethyl)phenyl]isoquinoline-1,3(2H,4H)-dione
-
-
2-hydroxyisoquinoline-1,3(2H,4H)-dione
2-methoxyisoquinoline-1,3(2H,4H)-dione
-
-
2-[(10Z)-heptadec-10-en-1-yl]-6-hydroxybenzoic acid
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
3'-azido-3'-deoxythymidine
3'-azido-3'-deoxythymidine 5'-(dihydrogen phosphate)
-
inhibits RNase H in vitro, but is not selectively active against RNase H. Does not exhibit inhibitory activity against RNase H in the HIV-1 replication process
3'-azido-3'-deoxythymidine 5'-phosphate
-
more sensitive to inhibition with poly(rGdC) than with poly(rAdT) as substrate. Competitive inhibitor with respect to substrate in Mn2+, uncompetitive inhibitor in Mg2+
3,4-dihydroxy-N'-[(E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
-
specific inhibitor of reverse transcriptase RNase H activity (IC50 value is about 0.5 microM) and has relatively limited activity against the DNA polymerase activity of reverse transcriptase. It is non-cytotoxic and inhibits the replication of a variety of drug-resistant HIV-1 reverse transcriptase mutants
3,7-dihydroxytropolones
-
-
3,9,11,14,15-pentahydroxy-7-methoxy-N,N,N,10-tetramethyl-1,8,13-trioxo-1,3,5,6,8,13-hexahydro-2H-tetraceno[1,2-f]isoindol-2-aminium
-
-
3-pentadecylphenol
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
3-tridecylphenol
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
3-[(10Z)-heptadec-10-en-1-yl]phenol
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
3-[(8Z)-pentadec-8-en-1-yl]phenol
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
3-[(E)-(carbamimidoylhydrazono)methyl]-1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
3-[(E)-(tert-butylhydrazono)methyl]-1,9,11,14-tetrahydroxy-7-methoxy-10-methyl-8,13-dioxo-5,6,8,13-tetrahydrobenzo[a]tetracene-2-carboxylic acid
-
-
3-[(E)-[4-[(E)-2-carboxyethenyl]phenyl]diazenyl]-7-[([6-[(E)-[4-[(E)-2-carboxyethenyl]phenyl]diazenyl]-5-hydroxy-7-sulfonatonaphthalen-2-yl]carbamoyl)amino]-4-hydroxynaphthalene-2-sulfonate
-
-
4'-chloro-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]biphenyl-4-carbohydrazide
-
4-(1-chloro-1,1-difluoromethyl)-4-(2-phenylethynyl)-6-chloro-2H-3,1-benzoxazin-2-one
-
i.e. NNRTI, an efavirenz analogue, IC50 values for wild-type enzyme are 0.000002-0.000005 mM with substrates DNA-17-nucleotide-RNA hybrid or DNA-18-nucleotide-RNA hybrid, and 0.001 mm for substrate DNA-15-nucleotide-RNA hybrid or DNA-16-nucleotide-RNA hybrid, effect on mutant enzymes, overview
4-(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)benzoic acid
-
-
4-(5-benzamidothiophen-2-yl)-2,4-dioxobutanoic acid
-
IC50 values determined by two different assay variants
4-(dimethylamino)-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
-
4-methoxy-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
-
4-tert-butyl-N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
-
4-[(4'-aminomethyl-1,1'-biphenyl)methyl]-1-hydroxy-1,8-naphthyridin-2-one
4-[1-(4-fluorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxobutanoic acid
-
L-731,988
4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid
-
a diketo acid RNase H inhibitor, IC50 values for wild-type and mutant enzymes are 0.002-0.0035 mM with all substrates, effect on mutant enzymes, overview
4-[5-(benzoylamino)tien-2-yl]-2,4-dioxobutanoic acid
-
diketo acid derivative
4-[5-benzoylamino) thien-2-yl]-2,4-dioxobutanoic acid
-
inhibits RNase H by binding to the active site and chelating the essential Mg2+
5-chloro-2-hydroxyisoquinoline-1,3(2H,4H)-dione
-
-
5-chloro-2-hydroxyisoquinoline-1,3(2H,4H-dione)
-
is not candidate therapeutics because it is cytotoxic
5-nitrofuran-2-carboxylic acid adamantan-1-carbamoyl methyl ester
5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydro-furan-2-yl-methyl)-carbamoyl] methyl ester
20-25 microM effectively inhibited HIV-1 replication
5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydrofuran-2-ylmethyl)-carbamoyl] methyl ester
-
derivative of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester. 20-25 microM effectively inhibited HIV-1 replication
5-tridecylbenzene-1,3-diol
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
5-[(8Z)-pentadec-8-en-1-yl]benzene-1,3-diol
-
isolated from the CH2Cl2 extracts of the sacrotestas of Ginkgo biloba
5-[N-(4-fluorophenoxy)ethanimidoyl]-1,6-dihydroxy-4-methylpyridin-2(1H)-one
-
-
5-[N-(benzyloxy)ethanimidoyl]-1,6-dihydroxy-4-methylpyridin-2(1H)-one
-
-
5-[N-[(2-aminophenyl)methoxy]ethanimidoyl]-1,6-dihydroxy-4-methylpyridin-2(1H)-one
-
-
5-[N-[(2-fluorophenyl)methoxy]ethanimidoyl]-1,6-dihydroxy-4-methylpyridin-2(1H)-one
-
-
5-[N-[(4-fluorophenyl)methoxy]ethanimidoyl]-1,6-dihydroxy-4-methylpyridin-2(1H)-one
-
-
7-(3,4-dihydroxyphenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione
-
-
7-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione
-
-
7-(furan-2-yl)-2-hydroxy-isoquinoline-1,3(2H,4H)-dione
7-benzamido-N,N-diethyl-2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide
-
-
7-bromo-2-hydroxyisoquinoline-1,3(2H,4H)-dione
-
-
7-chloro-2-hydroxyisoquinoline-1,3(2H,4H)-dione
-
-
8-methoxy-11-methyl-1,9,14-trioxo-2-phenyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazine-10,12,15,16-tetrayl tetraacetate
-
-
8-methoxy-11-methyl-1,9,14-trioxo-2-propyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazine-10,12,15,16-tetrayl tetraacetate
-
-
9,11,14,15-tetrahydroxy-7-methoxy-10-methyl-8,13,16-trioxo-1,2,3a,5,6,8,13,16-octahydrotetraceno[1,2-f][1,3]thiazolo[2,3-a]isoindole-1-carboxylic acid
-
-
acetylshikonin
-
inhibits weakly
alpha-thujaplicin
ardimerin digallate
beta-thujaplicin
beta-thujaplicinol
BPH218
-
potent inhibitor of ATP-mediated phosphorolytic excision of 3'-terminal zidovudine 5'-monophosphate (in vitro IC50 value is about 2 microM)
capravirine
-
a nonnucleoside reverse transcriptase inhibitor, inhibits the 5' to 3' directed RNase H activity
Cl-
-
the wild-type and mutant enzymes bind the substrate considerably less tightly at higher concentrations
deoxyshikonin
-
inhibits weakly
Dextran sulfate
-
inhibits RNase H in vitro, but is not selectively active against RNase H. Does not exhibit inhibitory activity against RNase H in the HIV-1 replication process
-
dihydroxy benzoyl naphthyl hydrazone
-
also have inhibitory activity against drug-resistant HIV-1 RT variants Y181C RT and Y188l RT. NNRTI Efavirenz shows no inhibitory effect under the same conditions
efavirenz
ethyl (5E)-6-[1-(4-fluorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoate
-
RDS 1643, good selectivity and high potency in enzyme and cell culture assay
ethyl 3-(10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl)propanoate
-
-
ethyl 6-hydroxy-2-methoxy-5,7-dioxo-5,6,7,8-tetrahydro-1,6-naphthyridine-8-carboxylate
-
-
gamma-thujaplicin
GW8248
-
a nonnucleoside reverse transcriptase inhibitor, inhibits the 5' to 3' directed RNase H activity
heparin
-
inhibits RNase H in vitro, but is not selectively active against RNase H. Does not exhibit inhibitory activity against RNase H in the HIV-1 replication process
hyemaloside A
-
isolated from the evergreen tree Eugenia hyemalis
hyemaloside B
-
isolated from the evergreen tree Eugenia hyemalis
hyemaloside C
-
isolated from the evergreen tree Eugenia hyemalis
illimaquinone
juglone
-
poor inhibitory activity
madurahydroxylactone
-
a secondary metabolite from the soil bacterium Nonomuraea rubra, belonging to the family of benzo[a]naphthacenequinone antibiotics
manicol
methyl 10,15,16-trihydroxy-8-methoxy-11-methyl-1,9,14-trioxo-2-phenyl-1,2,6,7,9,14-hexahydrotetraceno[1,2-g]phthalazin-12-yl carbonate
-
-
methyl 7-benzamido-2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate
-
-
Mg2+
-
inhibitory at concentrations greater than 10 mM
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]-4-methylbenzohydrazide
-
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]-4-phenoxybenzohydrazide
-
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]benzohydrazide
-
N'-[(1E)-(2-methoxynaphthalen-1-yl)methylidene]biphenyl-4-carbohydrazide
-
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-phenylacetamide
-
-
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-nitrobenzamide
-
-
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-fluorobenzamide
-
-
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide
-
-
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide
-
-
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)pentanamide
-
-
N-(4-chlorophenyl)-6-hydroxy-2-methoxy-5,7-dioxo-5,6,7,8-tetrahydro-1,6-naphthyridine-8-carboxamide
-
-
N-(4-fluorophenyl)-6-hydroxy-2-methoxy-5,7-dioxo-5,6,7,8-tetrahydro-1,6-naphthyridine-8-carboxamide
-
-
N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone
N-(4-tert-butylbenzoyl)-2-hydroxynaphthaldehyde hydrazone
BBNH, the residue Tyr501 is integral in the binding interaction, mechanism
N-acyl hydrazone analogues
-
-
N-[(4-fluorophenyl)methyl]-2,6-dihydroxy-5,7-dioxo-5,6,7,8-tetrahydro-1,6-naphthyridine-8-carboxamide
-
-
N-[3-(aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-furancarboxamide
naphthazarin
-
inhibits weakly
nevirapine
non-nucleoside reverse transcriptase inhibitors
-
non-nucleotide or non-nucleoside reverse transcriptase inhibitor
-
nonnucleoside reverse transcriptase inhibitor
-
NNRTI
-
nootkatin
-
i.e. 2-hydroxy-5-(3-methyl-2-butenyl)-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one
nucleoside analog reverse transcriptase inhibitor
-
NRTI
-
nucleoside analog RT inhibitors
-
nucleotide or nucleoside reverse transcriptase inhibitor
-
p-hydroxymercuribenzoate
Herpes simplex virus
-
5 mM lead to 90% inhibition
Phosphonoformate
-
the inhibitor that bind in the reverse transcriptase polymerase domain inhibits also RNase H activity, IC value for the wild-type enzyme is 0.0015 mM versus substrate DNA-18-nucleotide-RNA hybrid, with the other substrates the IC50 value is above 0.025 mM
Phosphonoformic acid
-
inhibits both the polymerase and the RNase H activities
Plumbagin
-
poor inhibitory activity
RNA-DNA duplex with bound drugs
-
two chimeric RNA-DNA duplexes mimicking intermediates of the reverse trancriptase reaction with bound 4,5-disubstituted 2-deoxystreptamine aminoglycosides, i.e. neomycin, paromomycin, and ribostamycin, inhibit specifically and competitively the RNase H cleavage reaction by 60-95% and 15-91%, respectively, overview
-
shikometabolin C
-
inhibits weakly
shikometabolin D
-
inhibits weakly
shikonin
-
inhibits weakly
single-stranded DNA aptamer RT1t49
-
single-stranded RNA aptamer RT1t49
-
tert-butyl [7-(1-hydroxypropyl)-8-methyl-9-oxo-12-(trimethylsilyl)-9,11-dihydroindolizino[1,2-b]quinolin-2-yl]carbamate
-
mappicine analogue
TMC-125
-
a nonnucleoside reverse transcriptase inhibitor, inhibits the 5' to 3' directed RNase H activity
trihydroxybenzoylbiphenyl carboxylate hydrazone
trihydroxybenzoylnaphthyl hydrazone
tropolone
zidovudine triphosphate
-
i.e. AZTTP
[(4-chlorophenyl) hydrazono] propanedioic acid
-
inhibits the RNase H of HIV-1 reverse transcriptase with potency similar to that of N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone. It is specific for RNase H and does not inhibit the DNA polymerase activity of reverse transcriptase. Inhibits RNase H by binding to the active site and chelating the essential Mg2+
[(4-chlorophenyl)hydrazono]propanedioic acid
-
inhibits by directly chelating Mg2+
[10,12,15,16-tetrakis(cyclohexyloxy)-8-methoxy-11-methyl-1,9,14-trioxo-6,7,9,14-tetrahydrotetraceno[1,2-g]phthalazin-2(1H)-yl]acetic acid
-
-
additional information
-