3.1.11.1: exodeoxyribonuclease I
This is an abbreviated version!
For detailed information about exodeoxyribonuclease I, go to the full flat file.
Word Map on EC 3.1.11.1
-
3.1.11.1
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camp
-
cyclase
-
adenylate
-
monophosphate
-
agonist
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forskolin
-
ibmx
-
cardiac
-
arterial
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theophylline
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pulmonary
-
rolipram
-
ventricular
-
calmodulin
-
prostaglandin
-
inotropic
-
guanosine
-
3-isobutyl-1-methylxanthine
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milrinone
-
vasodilator
-
isoproterenol
-
klenow
-
camp-dependent
-
contractile
-
polymerases
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adenylyl
-
sildenafil
-
isobutylmethylxanthine
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guanylate
-
dibutyryl
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papaverine
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beta-adrenergic
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erectile
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hemodynamic
-
calmodulin-dependent
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prostacyclin
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rhodopsin
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guanylyl
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beta-adrenoceptor
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3',5'-monophosphate
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pentoxifylline
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isoprenaline
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dipyridamole
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dntp
-
drug development
-
transducin
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molecular biology
-
tadalafil
-
phototransduction
-
chronotropic
-
bronchodilator
-
analysis
-
dobutamine
- 3.1.11.1
- camp
- cyclase
- adenylate
- monophosphate
- agonist
- forskolin
- ibmx
- cardiac
- arterial
- theophylline
- pulmonary
- rolipram
- ventricular
- calmodulin
- prostaglandin
-
inotropic
- guanosine
- 3-isobutyl-1-methylxanthine
- milrinone
-
vasodilator
- isoproterenol
-
klenow
-
camp-dependent
-
contractile
- polymerases
-
adenylyl
- sildenafil
- isobutylmethylxanthine
-
guanylate
-
dibutyryl
- papaverine
-
beta-adrenergic
-
erectile
-
hemodynamic
-
calmodulin-dependent
- prostacyclin
- rhodopsin
-
guanylyl
-
beta-adrenoceptor
-
3',5'-monophosphate
- pentoxifylline
- isoprenaline
- dipyridamole
- dntp
- drug development
- transducin
- molecular biology
- tadalafil
-
phototransduction
-
chronotropic
-
bronchodilator
- analysis
- dobutamine
Reaction
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =
Synonyms
3'->5'exonuclease, 3'-to-5' exonuclease, 3'5' exonuclease, 30–50 ssExo, DNA deoxyribophosphodiesterase, DNA polymerase D, DNA polymerase I, dRPase, E. coli exonuclease I, EC 3.1.4.25, Escherichia coli exonuclease I, Exo I, Exo1, EXO1b, ExoA, ExoI, exonuclease 1, exonuclease 1b, exonuclease I, exonuxlease 1, hEXO1, More, OsEXO1, PF2046, PfuExo I, PhoExo I, phosphodiesterase, Pol, Pol BI, POlB1, polD, SbcB15, single-strand DNA 3'-5' exonuclease, single-strand-specific 3'-5' exonuclease, single-stranded DNA-specific 3'-5' exonuclease I, Sso polB1, SSO0552, tthb178, WRN
ECTree
3.1.11.1 exodeoxyribonuclease IAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.1.11.1 - exodeoxyribonuclease I
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-end 3'-dAMP-labeled 7,8-dihydro-8-oxoguanine-cytosine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled alpha-anomeric 2'-deoxyadenosine-thymidine duplex + H2O
?
low efficiency
-
-
?
3'-sticky-ended double-strand DNA + H2O
3'-blunt-ended double-strand DNA + nucleoside 5'-monophosphate
-
-
-
?
damaged DNA + H2O
?
-
requirement of the Mre11 complex and exonuclease 1, playing overlapping roles, for activation of the Mec1 signaling pathway, Mre11 and Exo1 collaborate in producing long single-stranded DNA tails at double-strand breaks of DNA and promote Mec1 association with the double-strand break, Mre11 and Exo1 contribute to the activation of the replication checkpoint pathway, modeling of complex activity
-
-
?
DNA containing mismatches + H2O
?
-
the enzyme is involved in mismatch repair and participates directly in somatic hypermutation and class-switch recombination
-
-
?
nicked circular single stranded DNA containing mismatches + H2O
?
-
-
-
?
nicked DNA containing mismatches
?
-
the enzyme is part of the mismatch repair machinery, MMR, the replication factors PCNA and RFC, and Ku70/80 modulate the directionality of the enzyme-mediated excision in DNA mismatch repair, complex components and reaction process, overview
-
-
?
nicked double stranded DNA containing mismatches + H2O
?
-
-
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
single-stranded polydeoxyribonucleotide + H2O
single-stranded oligodeoxynucleotide + nucleoside 5'-monophosphate
3'-end 3'-dAMP-labeled (5R,6S)-thymine glycol-thymidine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled (5R,6S)-thymine glycol-thymidine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 1,N6-ethenoadenine-thymidine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 1,N6-ethenoadenine-thymidine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrothymine-adenosine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrothymine-adenosine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrouracil-guanine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 5,6-dihydrouracil-guanine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 5-hydroxycytosine-guanine duplex + H2O
?
-
-
-
?
3'-end 3'-dAMP-labeled 5-hydroxycytosine-guanine duplex + H2O
?
-
-
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
nucleic acid binding requires two distinct recognition sites in oligodeoxyribonucleotides
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
nucleic acid binding requires two distinct recognition sites in oligodeoxyribonucleotides
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
E. coli exonuclease I, III and V are required for stable maintenance of ColE1-related plasmids
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
inactivation of exonuclease I diverts most of plasmid replication activity from circular monomer production to synthesis of linear multimers
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
implicated in DNA repair and recombination pathways
-
?
single-stranded oligodeoxyribonucleotide + H2O
single-stranded oligodeoxyribonucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded polydeoxyribonucleotide + H2O
single-stranded oligodeoxynucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded polydeoxyribonucleotide + H2O
single-stranded oligodeoxynucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded polydeoxyribonucleotide + H2O
single-stranded oligodeoxynucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded polydeoxyribonucleotide + H2O
single-stranded oligodeoxynucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded polydeoxyribonucleotide + H2O
single-stranded oligodeoxynucleotide + nucleoside 5'-monophosphate
-
-
-
?
single-stranded polydeoxyribonucleotide + H2O
single-stranded oligodeoxynucleotide + nucleoside 5'-monophosphate
-
-
-
?
ssDNA + H2O
?
TTHB178 possesses 3'–5'-ssExo activity that degrades ssDNAs containing deaminated and methylated bases, but not ssDNA containing oxidized bases or abasic sites. The enzyme functions in various DNA repair systems in cooperation with or independently of RecJ
-
-
?
ssDNA + H2O
?
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
TTHB178 possesses 3'–5'-ssExo activity that degrades ssDNAs containing deaminated and methylated bases, but not ssDNA containing oxidized bases or abasic sites. The enzyme functions in various DNA repair systems in cooperation with or independently of RecJ
-
-
?
additional information
?
-
-
the enzyme is part of the mismatch repair machinery, MMR, the replication factors PCNA and RFC modulate the directionality of the enzyme-mediated excision in DNA mismatch repair, complex components and reaction process, overview
-
-
?
additional information
?
-
-
role for the single-stranded exonuclease in guarding the genome against mutagenesis by removing excess single-stranded DNA that, if left, leads to SOS induction and PolIV-dependent mutagenesis
-
-
?
additional information
?
-
ssDNA-binding protein stimulates ExoI by recruiting the enzyme to its substrate and provides a structural paradigm for understanding ssDNA-binding protein's organizational role in genome maintenance
-
-
?
additional information
?
-
-
ssDNA-binding protein stimulates ExoI by recruiting the enzyme to its substrate and provides a structural paradigm for understanding ssDNA-binding protein's organizational role in genome maintenance
-
-
?
additional information
?
-
-
the enzyme is involved in repair of DNA which is damaged by UV radiation, the constitutive enzyme is phosphorylated and rapidly degraded upon arrest of DNA replication in S phase via the ubiquitin-proteasome pathway, regulation, overview
-
-
?
additional information
?
-
-
hEXO1 does not exhibit endonuclease activity on 5'-flaps bearing structures formed by CTG or CGG repeats, although it can excise these substrates. hEXO1 is not affected by the stem-loops formed by CTG repeats interrupting duplex regions adjacent to 5'-flaps, but the enzymes is inhibited by G4 structures formed by CGG repeats in analogous positions
-
-
?
additional information
?
-
the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo
-
-
?
additional information
?
-
-
the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo
-
-
?
additional information
?
-
the enzyme has 5'->3' exonuclease activity, as well as 5' structure specific DNA endonuclease activity and 5'->3' RNase H activity
-
-
?
additional information
?
-
-
the enzyme has 5'->3' exonuclease activity, as well as 5' structure specific DNA endonuclease activity and 5'->3' RNase H activity
-
-
?
additional information
?
-
-
the enzyme is associated to Mlh1 and binds to mutating V regions of DNA in BL2 cells
-
-
?
additional information
?
-
-
Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals
-
-
?
additional information
?
-
-
Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals
-
-
?
additional information
?
-
OsEXO1 interacts with DNA polymerase lambda and replication protein A subunits. OsEXO1 plays an important role in both cell proliferation and UV-damaged nuclear DNA repair pathway under dark conditions
-
-
?
additional information
?
-
-
OsEXO1 interacts with DNA polymerase lambda and replication protein A subunits. OsEXO1 plays an important role in both cell proliferation and UV-damaged nuclear DNA repair pathway under dark conditions
-
-
?
additional information
?
-
-
the enzyme is part of the mismatch repair complex, Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective rad53 mutant cells by resecting newly synthesized chains and resolving the sister chromatid junctions that cause regression of collapsed forks, mechanism modeling, overview
-
-
?
additional information
?
-
-
Exo1 is involved in 5' strand resection. Sgs1 and Exo1 can act independently to remove the 5' strand. Exo1 promotes resection in the absence of Dna2. Dna2 and Exo1 nucleases process 5' strands at a DSB
-
-
?
additional information
?
-
-
yeast Exo1 interacts with human MLH1 through its Mlh1 interacting protein box (R-SK-[Y/F]-F-motif). A mutant of MLH1 targeted at site S2 (Mlh1-E682A) behaves as a hypomorphic form of Exo1. The site S2 in Mlh1 mediates Exo1 recruitment in order to optimize mismatch repair-dependent mutation avoidance
-
-
?
additional information
?
-
-
Exo1 possesses both 5'-3' exonuclease and 5' flap endonuclease activities
-
-
?
additional information
?
-
Ku restricts the access of the enzyme to DNA ends. DNA with ends occluded by the DNA end-joining factor Ku70-Ku80 is a suitable substrate for long-range 5'->3' resection when a nick is introduced at a locale proximal to one of the Ku-bound DNA ends
-
-
?
additional information
?
-
-
Ku restricts the access of the enzyme to DNA ends. DNA with ends occluded by the DNA end-joining factor Ku70-Ku80 is a suitable substrate for long-range 5'->3' resection when a nick is introduced at a locale proximal to one of the Ku-bound DNA ends
-
-
?
additional information
?
-
the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo
-
-
?
additional information
?
-
-
the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo
-
-
?
additional information
?
-
-
Exo1 possesses both 5'-3' exonuclease and 5' flap endonuclease activities
-
-
?
