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Literature summary for 3.1.11.1 extracted from

  • Cotta-Ramusino, C.; Fachinetti, D.; Lucca, C.; Doksani, Y.; Lopes, M.; Sogo, J.; Foiani, M.
    Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells (2005), Mol. Cell, 17, 153-159.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the enzyme is part of the mismatch repair complex, Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective rad53 mutant cells by resecting newly synthesized chains and resolving the sister chromatid junctions that cause regression of collapsed forks, mechanism modeling, overview ?
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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several wild-type and mutant strains
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mismatched DNA + H2O the enzyme shows 5' to 3' exonuclease activity Saccharomyces cerevisiae ?
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?
additional information the enzyme is part of the mismatch repair complex, Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective rad53 mutant cells by resecting newly synthesized chains and resolving the sister chromatid junctions that cause regression of collapsed forks, mechanism modeling, overview Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
Exo1
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Saccharomyces cerevisiae
exonuclease 1
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Saccharomyces cerevisiae