3.1.11.1: exodeoxyribonuclease I

This is an abbreviated version!
For detailed information about exodeoxyribonuclease I, go to the full flat file.

Reaction

Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =

Synonyms

3'->5'exonuclease, 3'-to-5' exonuclease, 3'5' exonuclease, 30�50 ssExo, DNA deoxyribophosphodiesterase, DNA polymerase D, DNA polymerase I, dRPase, E. coli exonuclease I, EC 3.1.4.25, Escherichia coli exonuclease I, Exo I, Exo1, EXO1b, ExoA, ExoI, exonuclease 1, exonuclease 1b, exonuclease I, exonuxlease 1, hEXO1, More, OsEXO1, PF2046, PfuExo I, PhoExo I, phosphodiesterase, Pol, Pol BI, POlB1, polD, SbcB15, single-strand DNA 3'-5' exonuclease, single-strand-specific 3'-5' exonuclease, single-stranded DNA-specific 3'-5' exonuclease I, Sso polB1, SSO0552, tthb178, WRN

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters

                3.1.11.1 exodeoxyribonuclease I

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8	Activating Compound
12229	AA Sequence
7	Application
1	CAS Registry Number
26	Cloned(Commentary)
8	Crystallization (Commentary)
7465	Disease/ Diagnostics
31	General Information
4	General Stability
17	IC50 Value
12	Inhibitors
10	kcat/KM [mM/s]
14	KM Value [mM]
11	Localization
17	Metals/Ions
12	Molecular Weight [Da]
69	Natural Substrates/ Products (Substrates)
221	Organism
45	PDB ID
9	pH Optimum
4	Posttranslational Modification
51	Protein Variants
16	Purification (Commentary)
4	Reaction
1	Reaction Type
79	Reference
36	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
14	Subunits
132	Synonyms
8	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
11	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.1.11.1 - exodeoxyribonuclease I

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

14-3-3 isoform eta

Homo sapiens

Q9UQ84

-

750362

-

14-3-3 isoform sigma

Homo sapiens

Q9UQ84

-

750362

-

E. coli single-stranded binding protein

Escherichia coli

-

four molecules bind to exonuclease, carboxy terminus is the recognition site for the exonuclease, binds ssDNA to establish a conformation suitable for replication, recombination and repair

133942

-

proliferating cell nuclear antigen

Homo sapiens

Q9UQ84

-

750362

-

additional information

5 entries

-

additional information

Escherichia coli

P04995

ssDNA-binding protein stimulates ExoI by recruiting the enzyme. ExoI/ssDNA-binding protein complex formation is necessary, but not sufficient for ssDNA-binding protein stimulation of ExoI activity

700988

-

additional information

Escherichia coli

-

ssDNA-binding protein stimulates ExoI by recruiting the enzyme. ExoI/ssDNA-binding protein complex formation is necessary, but not sufficient for ssDNA-binding protein stimulation of ExoI activity

700988

-

additional information

Escherichia coli

-

ExoI enzymatic activity is stimulated by single-stranded DNA-binding protein, whereby the hydrophobic C-terminal residues play critical roles in ExoI binding

707503

-

additional information

Homo sapiens

-

human BLM helicase, a member of the RecQ family, stimulates the nucleolytic activity of Exo1. Stimulation of hExo1 by BLM does not require ATP. Stimulation is specific because other RecQ homologs (human WRN, RecQ1, RecQ4 and RecQ5beta and Escherichia coli RecQ) fail to stimulate Exo1. RPA does not affect the nuclease activity of Exo1 alone, nor does it appreciably change substrate utilization by Exo1 in the presence of BLM helicase. BLM helicase physically interacts with Exo1

700958

-

additional information

Homo sapiens

-

human EXO1 excision depends on the presence of a G loop, requires a nick and depends on transcription and transcriptional orientation

700957

-