3.1.11.1: exodeoxyribonuclease I

This is an abbreviated version!
For detailed information about exodeoxyribonuclease I, go to the full flat file.

Reaction

Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =

Synonyms

3'->5'exonuclease, 3'-to-5' exonuclease, 3'5' exonuclease, 30�50 ssExo, DNA deoxyribophosphodiesterase, DNA polymerase D, DNA polymerase I, dRPase, E. coli exonuclease I, EC 3.1.4.25, Escherichia coli exonuclease I, Exo I, Exo1, EXO1b, ExoA, ExoI, exonuclease 1, exonuclease 1b, exonuclease I, exonuxlease 1, hEXO1, More, OsEXO1, PF2046, PfuExo I, PhoExo I, phosphodiesterase, Pol, Pol BI, POlB1, polD, SbcB15, single-strand DNA 3'-5' exonuclease, single-strand-specific 3'-5' exonuclease, single-stranded DNA-specific 3'-5' exonuclease I, Sso polB1, SSO0552, tthb178, WRN

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters

                3.1.11.1 exodeoxyribonuclease I

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8	Activating Compound
12229	AA Sequence
7	Application
1	CAS Registry Number
26	Cloned(Commentary)
8	Crystallization (Commentary)
7465	Disease/ Diagnostics
31	General Information
4	General Stability
17	IC50 Value
12	Inhibitors
10	kcat/KM [mM/s]
14	KM Value [mM]
11	Localization
17	Metals/Ions
12	Molecular Weight [Da]
69	Natural Substrates/ Products (Substrates)
221	Organism
45	PDB ID
9	pH Optimum
4	Posttranslational Modification
51	Protein Variants
16	Purification (Commentary)
4	Reaction
1	Reaction Type
79	Reference
36	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
14	Subunits
132	Synonyms
8	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
11	Turnover Number [1/s]

General Stability

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General Stability on EC 3.1.11.1 - exodeoxyribonuclease I

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

30% loss of activity after sonification and storage for one day at 0°C

Escherichia coli

-

133950

50% loss of activity within one month when stored at 0°C or at -12°C

Escherichia coli

-

133951, 133952

ultraviolet C radiation, ionizing radiation, cisplatin and methylnitronitrosoguanidine do not affect the stability of the enzyme

Homo sapiens

Q9UQ84

750362