3.1.11.1: exodeoxyribonuclease I
This is an abbreviated version!
For detailed information about exodeoxyribonuclease I, go to the full flat file.
Word Map on EC 3.1.11.1
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3.1.11.1
-
camp
-
cyclase
-
adenylate
-
monophosphate
-
agonist
-
forskolin
-
ibmx
-
cardiac
-
arterial
-
theophylline
-
pulmonary
-
rolipram
-
ventricular
-
calmodulin
-
prostaglandin
-
inotropic
-
guanosine
-
3-isobutyl-1-methylxanthine
-
milrinone
-
vasodilator
-
isoproterenol
-
klenow
-
camp-dependent
-
contractile
-
polymerases
-
adenylyl
-
sildenafil
-
isobutylmethylxanthine
-
guanylate
-
dibutyryl
-
papaverine
-
beta-adrenergic
-
erectile
-
hemodynamic
-
calmodulin-dependent
-
prostacyclin
-
rhodopsin
-
guanylyl
-
beta-adrenoceptor
-
3',5'-monophosphate
-
pentoxifylline
-
isoprenaline
-
dipyridamole
-
dntp
-
drug development
-
transducin
-
molecular biology
-
tadalafil
-
phototransduction
-
chronotropic
-
bronchodilator
-
analysis
-
dobutamine
- 3.1.11.1
- camp
- cyclase
- adenylate
- monophosphate
- agonist
- forskolin
- ibmx
- cardiac
- arterial
- theophylline
- pulmonary
- rolipram
- ventricular
- calmodulin
- prostaglandin
-
inotropic
- guanosine
- 3-isobutyl-1-methylxanthine
- milrinone
-
vasodilator
- isoproterenol
-
klenow
-
camp-dependent
-
contractile
- polymerases
-
adenylyl
- sildenafil
- isobutylmethylxanthine
-
guanylate
-
dibutyryl
- papaverine
-
beta-adrenergic
-
erectile
-
hemodynamic
-
calmodulin-dependent
- prostacyclin
- rhodopsin
-
guanylyl
-
beta-adrenoceptor
-
3',5'-monophosphate
- pentoxifylline
- isoprenaline
- dipyridamole
- dntp
- drug development
- transducin
- molecular biology
- tadalafil
-
phototransduction
-
chronotropic
-
bronchodilator
- analysis
- dobutamine
Reaction
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =
Synonyms
3'->5'exonuclease, 3'-to-5' exonuclease, 3'5' exonuclease, 30–50 ssExo, DNA deoxyribophosphodiesterase, DNA polymerase D, DNA polymerase I, dRPase, E. coli exonuclease I, EC 3.1.4.25, Escherichia coli exonuclease I, Exo I, Exo1, EXO1b, ExoA, ExoI, exonuclease 1, exonuclease 1b, exonuclease I, exonuxlease 1, hEXO1, More, OsEXO1, PF2046, PfuExo I, PhoExo I, phosphodiesterase, Pol, Pol BI, POlB1, polD, SbcB15, single-strand DNA 3'-5' exonuclease, single-strand-specific 3'-5' exonuclease, single-stranded DNA-specific 3'-5' exonuclease I, Sso polB1, SSO0552, tthb178, WRN
ECTree
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Reference on EC 3.1.11.1 - exodeoxyribonuclease I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brody, R.S.
Nucleotide positions responsible for the processivity of the reaction of exonuclease I with oligodeoxyribonucleotides
Biochemistry
30
7072-7080
1991
Escherichia coli
Phillips, G.J.; Prasher, D.C.; Kushner, S.R.
Physical and biochemical characterization of cloned sbcB and xonA mutations from Escherichia coli K-12
J. Bacteriol.
170
2089-2094
1988
Escherichia coli
Phillips, G.J.; Kushner, S.R.
Determination of the nucleotide sequence for the exonuclease I structural gene (sbcB) of Escherichia coli K12
J. Biol. Chem.
262
455-459
1987
Escherichia coli
Genschel, J.; Curth, U.; Urbanke, C.
Interaction of E. coli single-stranded DNA binding protein (SSB) with exonuclease I. The carboxy-terminus of SSB is the recognition site for the nuclease
Biol. Chem.
381
183-192
2000
Escherichia coli
Silberstein, Z.; Cohen, A.
Synthesis of linear multimers of OriC and pBR322 derivatives in Escherichia coli K-12: Role of recombination and replication functions
J. Bacteriol.
169
3131-3137
1987
Escherichia coli
Brody, R.S.; Doherty, K.G.; Zimmermann, P.D.
Processivity and kinetics of the reaction of exonuclease I from Escherichia coli with polydeoxyribonucleotides
J. Biol. Chem.
261
7136-7143
1986
Escherichia coli
Brody, R.S.; Doherty, K.G.
Stereochemical course of hydrolysis of DNA by exonuclease I from Escherichia coli
Biochemistry
24
2072-2076
1985
Escherichia coli
Bassett, C.L.; Kushner, S.R.
Exonucleases I, III, and V are required for stability of ColE1-related plasmids in Escherichia coli
J. Bacteriol.
157
661-664
1984
Escherichia coli
Prasher, D.C.; Conarro L.; Kushner, S.R.
Amplification and purification of exonuclease I from Escherichia coli
J. Biol. Chem.
2558
6340-6343
1983
Escherichia coli
Mackay, V.; Linn, S.
Molecular structure of exonuclease I from Escherichia coli B
Biochim. Biophys. Acta
349
131-134
1974
Escherichia coli
Ray, R.K.; Reuben, R.; Molineux, I.; Gefter, M.
The purification of exonuclease I from Escherichia coli by affinity chromatography
J. Biol. Chem.
249
5379-5381
1974
Escherichia coli
Yajko, D.M.; Valentine, M.C.; Weiss, B.
Mutants of Escherichia coli with altered deoxyribonucleases. II. Isolation and characterization of mutants for exonuclease I
J. Mol. Biol.
85
323-342
1974
Escherichia coli
Lehman, I.R.
Exonuclease I (phosphodiesterase) (I) from Escherichia coli
Procedures in Nucleic Acid Research (Cantoni, G. L. , Davies, D. R. , eds. )
203-211
1966
Escherichia coli
-
Lehman, I.R.; Nussbaum, A.L.
The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase)
J. Biol. Chem.
239
2628-2636
1964
Escherichia coli
Viswanathan, M.; Burdett, V.; Baitinger, C.; Modrich, P.; Lovett, S.T.
Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair
J. Biol. Chem.
276
31053-31058
2001
Escherichia coli
Schmutte, C.; Sadoff, M.M.; Shim, K.S.; Acharya, S.; Fishel, R.
The interaction of DNA mismatch repair proteins with human exonuclease I
J. Biol. Chem.
276
33011-33018
2001
Homo sapiens
Breyer, W.A.; Matthews, B.W.
Structure of Escherichia coli exonuclease I suggests how processivity is achieved
Nat. Struct. Biol.
7
1125-1128
2000
Escherichia coli
Feschenko, V.V.; Rajman, L.A.; Lovett, S.T.
Stabilization of perfect and imperfect tandem repeats by single-strand DNA exonucleases
Proc. Natl. Acad. Sci. USA
100
1134-1139
2003
Escherichia coli
Burdett, V.; Baitinger, C.; Viswanathan, M.; Lovett, S.T.; Modrich, P.
In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair
Proc. Natl. Acad. Sci. USA
98
6765-6770
2001
Escherichia coli
Werner, J.H.; Cai, H.; Keller, R.A.; Goodwin, P.M.
Exonuclease I hydrolyzes DNA with a distribution of rates
Biophys. J.
88
1403-1412
2005
Homo sapiens
El-Shemerly, M.; Janscak, P.; Hess, D.; Jiricny, J.; Ferrari, S.
Degradation of human exonuclease 1b upon DNA synthesis inhibition
Cancer Res.
65
3604-3609
2005
Homo sapiens
Surtees, J.A.; Alani, E.
Replication factors license exonuclease I in mismatch repair
Mol. Cell
15
164-166
2004
Escherichia coli, Homo sapiens
Cotta-Ramusino, C.; Fachinetti, D.; Lucca, C.; Doksani, Y.; Lopes, M.; Sogo, J.; Foiani, M.
Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells
Mol. Cell
17
153-159
2005
Saccharomyces cerevisiae
Nakada, D.; Hirano, Y.; Sugimoto, K.
Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway
Mol. Cell. Biol.
24
10016-10025
2004
Saccharomyces cerevisiae
Bardwell, P.D.; Woo, C.J.; Wei, K.; Li, Z.; Martin, A.; Sack, S.Z.; Parris, T.; Edelmann, W.; Scharff, M.D.
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
Nat. Immunol.
5
224-229
2004
Mus musculus
Busam, R.D.
Structure of Escherichia coli exonuclease I in complex with thymidine 5-monophosphate
Acta Crystallogr. Sect. D
64
206-210
2008
Escherichia coli, Escherichia coli (P04995)
Tran, P.T.; Fey, J.P.; Erdeniz, N.; Gellon, L.; Boiteux, S.; Liskay, R.M.
A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair
DNA Repair
6
1572-1583
2007
Saccharomyces cerevisiae (P39875)
Hersh, M.N.; Morales, L.D.; Ross, K.J.; Rosenberg, S.M.
Single-strand-specific exonucleases prevent frameshift mutagenesis by suppressing SOS induction and the action of DinB/DNA polymerase IV in growing cells
J. Bacteriol.
188
2336-2342
2006
Escherichia coli
Misra, H.S.; Khairnar, N.P.; Kota, S.; Shrivastava, S.; Joshi, V.P.; Apte, S.K.
An exonuclease I-sensitive DNA repair pathway in Deinococcus radiodurans: a major determinant of radiation resistance
Mol. Microbiol.
59
1308-1316
2006
Escherichia coli
Yao, Y.; Wang, Q.; Hao, Y.; Tan, Z.
An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules
Nucleic Acids Res.
35
e68/1-e68/9
2007
Escherichia coli (P04995)
El-Shemerly, M.; Hess, D.; Pyakurel, A.K.; Moselhy, S.; Ferrari, S.
ATR-dependent pathways control hEXO1 stability in response to stalled forks
Nucleic Acids Res.
36
511-519
2008
Homo sapiens (Q9UQ84), Homo sapiens
Furukawa, T.; Imamura, T.; Kitamoto, H.K.; Shimada, H.
Rice exonuclease-1 homologue, OsEXO1, that interacts with DNA polymerase lambda and RPA subunit proteins, is involved in cell proliferation
Plant Mol. Biol.
66
519-531
2008
Oryza sativa (Q60GC1), Oryza sativa
Ramirez-Santos, J.; Garcia-Mata, V.; Poggio, S.; Camarena, L.; Gomez-Eichelmann, M.C.
Role of single-strand DNA 3-5 exonuclease ExoI and nuclease SbcCD in stationary-phase mutation in Escherichia coli K-12
Arch. Microbiol.
191
185-190
2009
Escherichia coli K-12
Yang, X.; Meng, X.; Li, B.; Chen, Z.; Zhao, D.; Tan, X.; Yu, Q.
Inhibition of in vitro amplification of targeted DNA fragment and activity of exonuclease I by a fullerene-oligonucleotide conjugate
Biologicals
36
223-226
2008
Escherichia coli
Wang, M.; Adikane, H.V.; Duhamel, J.; Chen, P.
Protection of oligodeoxynucleotides against nuclease degradation through association with self-assembling peptides
Biomaterials
29
1099-1108
2008
Escherichia coli
Zhu, Z.; Chung, W.H.; Shim, E.Y.; Lee, S.E.; Ira, G.
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
Cell
134
981-994
2008
Saccharomyces cerevisiae
Segurado, M.; Diffley, J.F.
Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks
Genes Dev.
22
1816-1827
2008
Saccharomyces cerevisiae
Dherin, C.; Gueneau, E.; Francin, M.; Nunez, M.; Miron, S.; Liberti, S.E.; Rasmussen, L.J.; Zinn-Justin, S.; Gilquin, B.; Charbonnier, J.B.; Boiteux, S.
Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair
Mol. Cell. Biol.
29
907-918
2009
Saccharomyces cerevisiae, Homo sapiens
Vallur, A.C.; Maizels, N.
Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions
Proc. Natl. Acad. Sci. USA
105
16508-16512
2008
Homo sapiens, Mus musculus
Nimonkar, A.V.; Ozsoy, A.Z.; Genschel, J.; Modrich, P.; Kowalczykowski, S.C.
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
Proc. Natl. Acad. Sci. USA
105
16906-16911
2008
Homo sapiens
Lu, D.; Keck, J.L.
Structural basis of Escherichia coli single-stranded DNA-binding protein stimulation of exonuclease I
Proc. Natl. Acad. Sci. USA
105
9169-9174
2008
Escherichia coli (P04995), Escherichia coli
Klapacz, J.; Meira, L.B.; Luchetti, D.G.; Calvo, J.A.; Bronson, R.T.; Edelmann, W.; Samson, L.D.
O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo
Proc. Natl. Acad. Sci. USA
106
576-581
2009
Mus musculus, Mus musculus C57/BL6J
Lu, D.; Windsor, M.A.; Gellman, S.H.; Keck, J.L.
Peptide inhibitors identify roles for SSB C-terminal residues in SSB/exonuclease I complex formation
Biochemistry
48
6764-6771
2009
Escherichia coli
Shimada, A.; Masui, R.; Nakagawa, N.; Takahata, Y.; Kim, K.; Kuramitsu, S.; Fukui, K.
A novel single-stranded DNA-specific 3'-5' exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways
Nucleic Acids Res.
38
5692-5705
2010
Thermus thermophilus (Q53VZ1), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q53VZ1)
Orans, J.; McSweeney, E.A.; Iyer, R.R.; Hast, M.A.; Hellinga, H.W.; Modrich, P.; Beese, L.S.
Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family
Cell
145
212-223
2011
Homo sapiens (Q9UQ84), Homo sapiens
Nakai, W.; Westmoreland, J.; Yeh, E.; Bloom, K.; Resnick, M.A.
Chromosome integrity at a double-strand break requires exonuclease 1 and MRX
DNA Repair
10
102-110
2011
Saccharomyces cerevisiae
Keelagher, R.E.; Cotton, V.E.; Goldman, A.S.; Borts, R.H.
Separable roles for exonuclease I in meiotic DNA double-strand break repair
DNA Repair
10
126-137
2011
Saccharomyces cerevisiae, Saccharomyces cerevisiae SK1
Liberti, S.E.; Andersen, S.D.; Wang, J.; May, A.; Miron, S.; Perderiset, M.; Keijzers, G.; Nielsen, F.C.; Charbonnier, J.B.; Bohr, V.A.; Rasmussen, L.J.
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks
DNA Repair
10
73-86
2011
Homo sapiens (Q9UQ84), Homo sapiens
Eid, W.; Steger, M.; El-Shemerly, M.; Ferretti, L.P.; Pena-Diaz, J.; Koenig, C.; Valtorta, E.; Sartori, A.A.; Ferrari, S.
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
EMBO Rep.
11
962-968
2010
Homo sapiens
Vallur, A.C.; Maizels, N.
Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats
J. Biol. Chem.
285
28514-28519
2010
Homo sapiens
Bahmed, K.; Seth, A.; Nitiss, K.C.; Nitiss, J.L.
End-processing during non-homologous end-joining: a role for exonuclease 1
Nucleic Acids Res.
39
970-978
2011
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Vallur, A.C.; Maizels, N.
Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA
PLoS ONE
5
e8908
2010
Homo sapiens
Sertic, S.; Pizzi, S.; Cloney, R.; Lehmann, A.R.; Marini, F.; Plevani, P.; Muzi-Falconi, M.
Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation
Proc. Natl. Acad. Sci. USA
108
13647-13652
2011
Homo sapiens
Lou, H.; Duan, Z.; Sun, T.; Huang, L.
Cleavage of double-stranded DNA by the intrinsic 3-5 exonuclease activity of DNA polymerase B1 from the hyperthermophilic archaeon Sulfolobus solfataricus at high temperature
FEMS Microbiol. Lett.
231
111-117
2004
Saccharolobus solfataricus (P26811), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (P26811), Saccharolobus solfataricus P2
Tori, K.; Ishino, S.; Kiyonari, S.; Tahara, S.; Ishino, Y.
A novel single-strand specific 3'-5' exonuclease found in the hyperthermophilic archaeon, Pyrococcus furiosus
PLoS One
8
e58497
2013
Pyrococcus furiosus (Q8TZE9), Pyrococcus furiosus
Komori, K.; Ishino, Y.
Functional interdependence of DNA polymerizing and 3-->5 exonucleolytic activities in Pyrococcus furiosus DNA polymerase I
Protein Eng.
13
41-47
2000
Pyrococcus furiosus
Lou, H.; Duan, Z.; Huo, X.; Huang, L.
Modulation of hyperthermophilic DNA polymerase activity by archaeal chromatin proteins
J. Biol. Chem.
279
127-132
2003
Saccharolobus solfataricus (P26811), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (P26811)
Miyazono, K.I.; Tsutsumi, K.; Ishino, Y.; Tanokura, M.
Expression, high-pressure refolding, purification, crystallization and preliminary X-ray analysis of a novel single-strand-specific 3'-5' exonuclease PhoExo I from Pyrococcus horikoshii OT3
Acta Crystallogr. Sect. F
70
1076-1079
2014
Pyrococcus horikoshii, Pyrococcus horikoshii DSM 12428
Korada, S.K.; Johns, T.D.; Smith, C.E.; Jones, N.D.; McCabe, K.A.; Bell, C.E.
Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion
Nucleic Acids Res.
41
5887-5897
2013
Escherichia coli (P04995), Escherichia coli
Tang, X.; Shen, Y.; Matsui, E.; Matsui, I.
Domain topology of the DNA polymerase D complex from a hyperthermophilic archaeon Pyrococcus horikoshii
Biochemistry
43
11818-11827
2004
Pyrococcus horikoshii
Redrejo-Rodriguez, M.; Vigouroux, A.; Mursalimov, A.; Grin, I.; Alili, D.; Koshenov, Z.; Akishev, Z.; Maksimenko, A.; Bissenbaev, A.; Matkarimov, B.; Saparbaev, M.; Ishchenko, A.; Morera, S.
Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA
Biochimie
128-129
20-33
2016
Bacillus subtilis (P37454), Bacillus subtilis 168 (P37454)
Keijzers, G.; Bohr, V.A.; Rasmussen, L.J.
Human exonuclease 1 (EXO1) activity characterization and its function on flap structures
Biosci. Rep.
35
e00206
2015
Homo sapiens (Q9UQ84), Homo sapiens
Keijzers, G.; Liu, D.; Rasmussen, L.
Exonuclease 1 and its versatile roles in DNA repair
Crit. Rev. Biochem. Mol. Biol.
51
440-451
2016
Homo sapiens (Q9UQ84)
-
Goellner, E.M.; Putnam, C.D.; Kolodner, R.D.
Exonuclease 1-dependent and independent mismatch repair
DNA Repair
32
24-32
2015
Saccharomyces cerevisiae (P39875), Saccharomyces cerevisiae, Homo sapiens (Q9UQ84), Homo sapiens
Keijzers, G.; Bakula, D.; Petr, M.A.; Madsen, N.G.K.; Teklu, A.; Mkrtchyan, G.; Osborne, B.; Scheibye-Knudsen, M.
Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer
Int. J. Mol. Sci.
20
E74
2018
Homo sapiens (Q9UQ84), Homo sapiens
Wang, W.; Daley, J.M.; Kwon, Y.; Xue, X.; Krasner, D.S.; Miller, A.S.; Nguyen, K.A.; Williamson, E.A.; Shim, E.Y.; Lee, S.E.; Hromas, R.; Sung, P.
A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection
J. Biol. Chem.
293
17061-17069
2018
Saccharomyces cerevisiae (P39875), Saccharomyces cerevisiae
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