3.1.11.1: exodeoxyribonuclease I

This is an abbreviated version!
For detailed information about exodeoxyribonuclease I, go to the full flat file.

Reaction

Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =

Synonyms

3'->5'exonuclease, 3'-to-5' exonuclease, 3'5' exonuclease, 30�50 ssExo, DNA deoxyribophosphodiesterase, DNA polymerase D, DNA polymerase I, dRPase, E. coli exonuclease I, EC 3.1.4.25, Escherichia coli exonuclease I, Exo I, Exo1, EXO1b, ExoA, ExoI, exonuclease 1, exonuclease 1b, exonuclease I, exonuxlease 1, hEXO1, More, OsEXO1, PF2046, PfuExo I, PhoExo I, phosphodiesterase, Pol, Pol BI, POlB1, polD, SbcB15, single-strand DNA 3'-5' exonuclease, single-strand-specific 3'-5' exonuclease, single-stranded DNA-specific 3'-5' exonuclease I, Sso polB1, SSO0552, tthb178, WRN

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters

                3.1.11.1 exodeoxyribonuclease I

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Results	in table
8	Activating Compound
12229	AA Sequence
7	Application
1	CAS Registry Number
26	Cloned(Commentary)
8	Crystallization (Commentary)
7465	Disease/ Diagnostics
31	General Information
4	General Stability
17	IC50 Value
12	Inhibitors
10	kcat/KM [mM/s]
14	KM Value [mM]
11	Localization
17	Metals/Ions
12	Molecular Weight [Da]
69	Natural Substrates/ Products (Substrates)
221	Organism
45	PDB ID
9	pH Optimum
4	Posttranslational Modification
51	Protein Variants
16	Purification (Commentary)
4	Reaction
1	Reaction Type
79	Reference
36	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
14	Subunits
132	Synonyms
8	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
11	Turnover Number [1/s]

Turnover Number

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Turnover Number on EC 3.1.11.1 - exodeoxyribonuclease I

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

115.5

single-stranded DNA

Escherichia coli

-

at 37°C, in 20 mM Tris-HCl buffer, pH 8.0, 100 mM NaCl, 3 mM MgCl2, 1 mM 2-mercaptoethanol, 0.1 g/l bovine serum albumin, 10% (v/v) glycerol, 5% (v/v) dimethyl sulfoxide

707503

0.71 - 7.5

ssDNA 10 mer

2 entries

-

0.4 - 5.3

ssDNA 21 mer

2 entries

-

0.23 - 1.9

ssDNA 28 mer

2 entries

-

0.17 - 2.3

ssDNA 40 mer

2 entries

-

0.19 - 1

ssDNA 50 mer

2 entries

-

0.71

ssDNA 10 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 37°C

710152

-

7.5

ssDNA 10 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 60°C

710152

-

0.4

ssDNA 21 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 37°C

710152

-

5.3

ssDNA 21 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 60°C

710152

-

0.23

ssDNA 28 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 37°C

710152

-

1.9

ssDNA 28 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 60°C

710152

-

0.17

ssDNA 40 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 37°C

710152

-

2.3

ssDNA 40 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 60°C

710152

-

0.19

ssDNA 50 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 37°C

710152

-

1

ssDNA 50 mer

Thermus thermophilus

Q53VZ1

pH 7.5, 60°C

710152

-