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Literature summary for 3.1.11.1 extracted from

  • Keelagher, R.E.; Cotton, V.E.; Goldman, A.S.; Borts, R.H.
    Separable roles for exonuclease I in meiotic DNA double-strand break repair (2011), DNA Repair, 10, 126-137.
    View publication on PubMed
Search for more literature for 3.1.11.1

Protein Variants

Protein Variants Comment Organism
D173A site-directed mutagenesis, the exo1-D173A mutant defective in nuclease activity is able to maintain crossing-over at wild-type levels in a number of genetic intervals. Exo1-D173A cells are able to maintain crossing-over despite reducedhDNAformation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae Exo1 possesses both 5'-3' exonuclease and 5' flap endonuclease activities ?
-
 ?
additional information Saccharomyces cerevisiae SK1 Exo1 possesses both 5'-3' exonuclease and 5' flap endonuclease activities ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 diverse genotypes, overview
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Saccharomyces cerevisiae SK1
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 diverse genotypes, overview
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Exo1 possesses both 5'-3' exonuclease and 5' flap endonuclease activities Saccharomyces cerevisiae ?
-
 ?
additional information Exo1 possesses both 5'-3' exonuclease and 5' flap endonuclease activities Saccharomyces cerevisiae SK1 ?
-
 ?

Synonyms

Synonyms Comment Organism
Exo1
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 Saccharomyces cerevisiae
exonuclease I
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 Saccharomyces cerevisiae
More Exo1 is a member of the Rad2 protein family Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function in addition to performing a variety of functions during mitotic growth, Exo1 is also important for the production of crossovers during meiosis, the nuclease activity of exonuclease I is essential for normal 5'-3' resection at the Spo11-dependent HIS4 hotspot in otherwise wild-type cells. This same activity is also required for normal levels of gene conversion at the locus. Exo1 also plays a nuclease-independent role in crossover promotion Saccharomyces cerevisiae