1.1.1.50: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

This is an abbreviated version, for detailed information about 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific), go to the full flat file.

Reaction

a 3alpha-hydroxysteroid
+
NAD(P)+
=
a 3-oxosteroid
+
NAD(P)H
+
H+

Synonyms

3 alpha-hydroxysteroid dehydrogenase, 3 alphaHD, 3-alpha-HSD, 3alpha-HSD, 3alpha-HSD/CR, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido-reductase, 3alpha-hydroxysteroid oxidoreductase, 3alpha-hydroxysteroid-5beta-oxidoreductase activity, 3alpha-OR, 3alpha-oxidoreductase, 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, AKR1C, AKR1C1-4, AKR1C17, AKR1C2, AKR1C3, AKR1C4, AKR1C9, aldo-keto reductase 1C2, bile-acid binding protein, chlordecone reductase, DD2, DD21, dihydrodiol dehydrogenase, HSD, HSD28, HSD29, hsdA, HSDH, hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)-dependent 3alpha-HSD, NADPH:5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, prostaglandin F2alpha-synthase, PT3HSD, sterognost 3alpha dehydrogenase, 3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type I 3alpha-HSD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

Cloned

Cloned on EC 1.1.1.50 - 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
co-expression of the enzyme with the LXR alpha receptor in HuH7 and HepG2 cells; expressed in Hu-H7 cells and Hep-G2 cells
-
D249A, D249S, and D249K mutants are expressed in Escherichia coli BL21(DE3) cells
-
expressed in COS-7 cells
expressed in Escherichia coli BL21 (DE3) cells
-
expression in baculovirus system with Sf9 cells
-
expression in Cos-1 cells
-
expression in Escherichia coli
expression of His-tagged wild-type and mutant enzymes in Escherichia coli
-
expression of isozyme AKR1C2 in Escherichia coli
-
expression of isozymes AKR1C1-4 in Escherichia coli
-
expression of type II isoform in Escherichia coli
-
expression of wild-type and mutant AKR1C17s in Escherichia coli strain BL21(DE3)
-
expression of wild-type and mutant enzymes in Escherichia coli
-
expression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
-
from human cDNA library, expression as GST-fusion protein in Escherichia coli strain BL21(DE3)
-
isozymes AKR1C1-AKR1C4, genetic organization, transient expression in COS-1 cells
-
overexpression as His-tagged fusion protein in Escherichia coli
-
overexpression in Escherichia coli
-
overexpression in Escherichia coli strain C41(DE3)
-
overexpression of AKR1C9 in Escherichia coli
-
overexpression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
-
overexpression of isozymes AKR1C1-AKR1C4 in Escherichia coli
-
overexpression of isozymes AKR1C1-AKR1C4 in Escherichia coli C41(DE3)
-
stable expression of AKR1C2 and AKR1C3 in androgen insensitive human prostate cancer PC-3 cells
-
stable expression of wild-type and mutant enzymes in HEK-293 cells
-
subclones revealed enzyme function in inflammation due to sequence homology to hydroxyprostaglandin dehydrogenase, prostaglandin F2alpha synthase
-
transient functional expression in COS-1 cells, stable functional expression in PC-3 cells and in LNCaP cells
-