1.1.1.50: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

This is an abbreviated version, for detailed information about 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific), go to the full flat file.

Reaction

a 3alpha-hydroxysteroid
+
NAD(P)+
=
a 3-oxosteroid
+
NAD(P)H
+
H+

Synonyms

3 alpha-hydroxysteroid dehydrogenase, 3 alphaHD, 3-alpha-HSD, 3alpha-HSD, 3alpha-HSD/CR, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido-reductase, 3alpha-hydroxysteroid oxidoreductase, 3alpha-hydroxysteroid-5beta-oxidoreductase activity, 3alpha-OR, 3alpha-oxidoreductase, 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, AKR1C, AKR1C1-4, AKR1C17, AKR1C2, AKR1C3, AKR1C4, AKR1C9, aldo-keto reductase 1C2, bile-acid binding protein, chlordecone reductase, DD2, DD21, dihydrodiol dehydrogenase, HSD, HSD28, HSD29, hsdA, HSDH, hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)-dependent 3alpha-HSD, NADPH:5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, prostaglandin F2alpha-synthase, PT3HSD, sterognost 3alpha dehydrogenase, 3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type I 3alpha-HSD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

Reference

Reference on EC 1.1.1.50 - 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
MacDonald, I.A.; Jellett, J.F.; Mahony, D.E.; Holdeman, L.V.
Bile salt 3alpha- and 12alpha-hydroxysteroid dehydrogenases from Eubacterium lentum and related organisms
Appl. Environ. Microbiol.
37
992-1000
1979
Eggerthella lenta
Manually annotated by BRENDA team
Mahony, D.E.; Meier, C.E.; MacDonald, I.A.; Holdeman, L.V.
Bile salt degradation by nonfermentative clostridia
Appl. Environ. Microbiol.
34
419-423
1977
Asaccharospora irregularis
Manually annotated by BRENDA team
MacDonald, I.A.; Mahony, D.E.; Jellet, J.F.; Meier, C.E.
NAD-dependent 3alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Eubacterium lentum ATCC no. 25559
Biochim. Biophys. Acta
489
466-476
1977
Eggerthella lenta
Manually annotated by BRENDA team
Mallonee, D.H.; Lijewski, M.A.; Hylemon, P.B.
Expression in Escherichia coli and characterization of a bile acid-inducible 3alpha-hydroxysteroid dehydrogenase from Eubacterium sp. strain VPI 12708
Curr. Microbiol.
30
259-263
1995
Eubacterium sp., Eubacterium sp. VPI 12708
Manually annotated by BRENDA team
Boutin, J.A.; Shikita, M.; Talalay, P.
Rat liver microsomal 3alpha-hydroxysteroid dehydrogenase and dihydrodiol dehydrogenase: solubilization, separation and partial purification
Biochem. Biophys. Res. Commun.
135
795-801
1986
Rattus norvegicus
Manually annotated by BRENDA team
Uwajima, T.; Terada, O.
Properties of crystalline 3alpha-hydroxysteroid dehydrogenase from Pseudomonas putida
Agric. Biol. Chem.
43
1521-1528
1979
Pseudomonas putida
-
Manually annotated by BRENDA team
Uwajima, T.; Takayama, K.; Terada, O.
Production, purification and crystallization of a 3alpha-hydroxysteroid dehydrogenase of Pseudomonas putida
Agric. Biol. Chem.
42
1577-1583
1978
Pseudomonas putida
-
Manually annotated by BRENDA team
Skalhegg, B.A.
On the 3alpha-hydroxysteroid dehydrogenase from Pseudomonas testosteroni. Purification and properties
Eur. J. Biochem.
46
117-125
1974
Comamonas testosteroni
Manually annotated by BRENDA team
Penning, T.M.; Sharp, R.B.; Krieger, N.R.
Purification and properties of 3alpha-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins
J. Biol. Chem.
260
15266-15272
1985
Rattus norvegicus
Manually annotated by BRENDA team
Ikeda, M.; Hattori, H.; Ikeda, N.; Hayakawa, S.; Ohmori, S.
Purification and characterization of the multiple forms of 3alpha-hydroxysteroid dehydrogenase in rat liver cytosol
Hoppe-Seyler's Z. Physiol. Chem.
365
377-391
1984
Rattus norvegicus
Manually annotated by BRENDA team
Hara, A.; Inoue, Y.; Nakagawa, M.; Naganeo, F.; Sawada, H.
Purification and characterization of NADP+-dependent 3alpha-hydroxysteroid dehydrogenase from mouse liver cytosol
J. Biochem.
103
1027-1034
1988
Mus musculus
Manually annotated by BRENDA team
Hastings, C.; Hansson, V.
Kinetic properties of the soluble 3alpha-hydroxysteroid dehydrogenase from rat testis and epididymis
J. Steroid Biochem.
14
705-711
1981
Rattus norvegicus
Manually annotated by BRENDA team
Jacobi, G.H.; Moore, R.J.; Wilson, J.D.
Characterization of the 3alpha-hydroxysteroid dehydrogenase of dog prostate
J. Steroid Biochem.
8
719-723
1977
Canis lupus familiaris
Manually annotated by BRENDA team
Nimrod, A.; Lamprecht, S.A.; Lindner, H.R.
Separation and characterization of two 3-hydroxysteroid oxidoreductases from the soluble fraction of rat ovarian cells
J. Steroid Biochem.
6
1205-1209
1975
Rattus norvegicus
Manually annotated by BRENDA team
Inano, H.; Hayashi, S.; Tamaoki, B.
Prostate 3alpha-hydroxysteroid dehydrogenase: its partial purification and properties
J. Steroid Biochem.
8
41-46
1977
Rattus norvegicus
Manually annotated by BRENDA team
Golf, S.W.; Graef, V.; Nowotny, E.
Solubilization and purification of a 3alpha-hydroxysteroid dehydrogenase in rat liver microsomes
Hoppe-Seyler's Z. Physiol. Chem.
357
35-40
1976
Rattus norvegicus
Manually annotated by BRENDA team
Skalhegg, B.A.
3alpha-Hydroxysteroid dehydrogenase from Pseudomonas testosteroni: kinetic properties with NAD and its thionicotinamide analogue
Eur. J. Biochem.
50
603-609
1975
Comamonas testosteroni
Manually annotated by BRENDA team
Jarabak, J.; Talalay, P.
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenase
J. Biol. Chem.
235
2147-2151
1960
Comamonas testosteroni
Manually annotated by BRENDA team
Squire, P.G.; Dehlin, S.; Porath, J.
Physical and chemical characterization of hydroxysteroid dehydrogenases from Pseudomonas testosteroni
Biochim. Biophys. Acta
89
409-421
1964
Comamonas testosteroni
Manually annotated by BRENDA team
Biswas, M.G.; Russel, D.W.
Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenase from rat and human prostate
J. Biol. Chem.
272
15959-15966
1997
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Chetyrkin, S.V.; Belyaeva, O.V.; Gough, W.H.; Kedishvili, N.Y.
Characterization of a novel type of human microsomal 3alpha-hydroxysteroid dehydrogenase
J. Biol. Chem.
276
22278-22286
2001
Homo sapiens
Manually annotated by BRENDA team
Campbell, J.S.; Karavolas, H.J.
Purification of the NADPH:5alpha-dihydroxyprogesterone 3alpha-hydroxysteroid oxidoreductase from female rat pituitary cytosol
J. Steroid Biochem. Mol. Biol.
37
215-222
1990
Rattus norvegicus
Manually annotated by BRENDA team
Iyer, R.B.; Binstock, J.M.; Schwartz, I.S.; Gordon, G.G.; Weinstein, B.I.; Southern, A.L.
Purification and properties of human hepatic 3alpha-hydroxysteroid dehydrogenase
J. Steroid Biochem. Mol. Biol.
43
343-349
1992
Homo sapiens
Manually annotated by BRENDA team
Maser, E.; Mobus, E.; Xiong, G.
Functional expression, purification, and characterization of 3alpha-hydroxysteroid dehydrogenase/Carbonyl reductase from Comamonas testosteroni
Biochem. Biophys. Res. Commun.
272
622-628
2000
Comamonas testosteroni
Manually annotated by BRENDA team
Lin, H.K.; Jez, J.M.; Schlegel, B.P.; Peehl, D.M.; Pachter, J.A.; Penning, T.M.
Expression and characterization of recombinant type 2: 3alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3alpha/17beta-HSD activity and cellular distribution
Mol. Endocrinol.
11
1971-1984
1997
Homo sapiens
Manually annotated by BRENDA team
Adachi, O.; Toyama, H.; Matsushita, K.
Purification and properties of 3alpha-hydroxysteroid dehydrogenase from Pseudomonas putida
Biosci. Biotechnol. Biochem.
61
131-137
1997
Pseudomonas putida
-
Manually annotated by BRENDA team
Nanjo, H.; Terada, T.; Umemura, T.; Nishinaka, T.; Mizoguchi, T.; Nishihara, T.
Characterization of bovine liver cytosolic 3alpha-hydroxysteroid dehydrogenase and its aldo-keto reductase activity
Int. J. Biochem.
24
815-820
1992
Bos taurus
Manually annotated by BRENDA team
Jin, Y.; Stayrook, S.E.; Albert, J.H.; Palackal, N.T.; Penning, T.M.; Lewis, M.
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate
Biochemistry
40
10161-10168
2001
Homo sapiens
Manually annotated by BRENDA team
Zhu, D.W.; Cantin, L.; Nahoum, V.; Rehse, P.; Luu-The, V.; Labrie, F.; Breton, R.; Lin S.X.
Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3alpha-hydroxysteroid dehydrogenase at 1.8 A resolution
Acta Crystallogr. Sect. D
57
589-591
2001
Homo sapiens
Manually annotated by BRENDA team
Gao, X.; Liu, J.; Li, G.
Purification and properties of 3alpha-hydroxysteroid dehydrogenase and 3-keto-5beta-steroid-DELTA4-dehydrogenase
Ann. N. Y. Acad. Sci.
864
383-392
1998
Pseudomonas sp.
Manually annotated by BRENDA team
Pawlowski, J.; Huizinga, M.; Penning, T.M.
Isolation and partial characterization of a full length cDNA clone for 3alpha-hydroxysteroid dehydrogenase: a potential target enzyme for nonsteroidal anti.inflammatory drugs
Agents Actions
34
289-293
1991
Rattus norvegicus
Manually annotated by BRENDA team
Sugimoto, Y.; Ohta, Y.; Morikawa, T.; Yamashita, T.; Yoshida, M.; Tamaoki, B.
In vitro metabolism of testosterone on hepatic tissue of chicken (Gallus domesticus)
J. Steroid Biochem.
35
271-279
1990
Gallus gallus
Manually annotated by BRENDA team
Stolz, A.; Takikawa, H.; Sugiyama, Y.; Kuhlenkamp, J.; Kaplowitz, N.
3alpha-hydroxysteroid dehydrogenase activity of the Y'bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance
J. Clin. Invest.
79
427-434
1987
Rattus norvegicus
Manually annotated by BRENDA team
Li, X.; Bertics, P.J.; Karavolas, H.J.
Regional distribution of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductases in female rat brain
J. Steroid Biochem. Mol. Biol.
60
311-318
1997
Rattus norvegicus
Manually annotated by BRENDA team
Krause, J.E.; Karavolas, H.J.
Subcellular location of hypothalamic progesterone metabolizing enzymes and evidence for distinct NADH- and NADPH-linked 3alpha-hydroxysteroid oxidoreductase activities
J. Steroid Biochem.
13
271-280
1980
Rattus norvegicus
Manually annotated by BRENDA team
Karavolas, H.J.; Hodges, D.R.
Changes in pituitary, hypothalamic and brain progestin-metabolizing enzyme activities during lactation
J. Steroid Biochem. Mol. Biol.
44
299-303
1993
Rattus norvegicus
Manually annotated by BRENDA team
Seitz, H.U.; Gaertner, D.E.
Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea
Plant Cell Tissue Organ Cult.
38
337-344
1994
Digitalis purpurea
-
Manually annotated by BRENDA team
Bertics, P.J.; Edman, C.F.; Karavolas, H.J.
Potent inhibition of the hypothalamic progesterone 5alpha-reductase by a 5alpha-dihydroprogesterone analog
J. Biol. Chem.
259
107-111
1984
Rattus norvegicus
Manually annotated by BRENDA team
Stuhlemmer, U.; Kreis, W.
Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata
Plant Physiol. Biochem.
34
85-91
1996
Digitalis lanata
-
Manually annotated by BRENDA team
Lindemann, P.; Luckner, M.
Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata
Phytochemistry
46
507-513
1997
Digitalis lanata
-
Manually annotated by BRENDA team
Morikawa, T.; Tamaoki, B.
Purification and characterization of 3alpha-hydroxysteroid dehydrogenase from chicken hepatic cytosol
J. Steroid Biochem. Mol. Biol.
37
569-574
1990
Gallus gallus
Manually annotated by BRENDA team
Ueda, S.; Oda, M.; Imamura, S.; Ohnishi, M.
Kinetic study of the enzymatic cycling reaction conducted with 3alpha-hydroxysteroid dehydrogenase in the presence of excessive thio-NAD+ and NADH
Anal. Biochem.
332
84-89
2004
Pseudomonas sp., Pseudomonas sp. B-0831
Manually annotated by BRENDA team
Trauger, J.W.; Jiang, A.; Stearns, B.A.; LoGrasso, P.V.
Kinetics of allopregnanolone formation catalyzed by human 3alpha-hydroxysteroid dehydrogenase type III (AKR1C2)
Biochemistry
41
13451-13459
2002
Homo sapiens
Manually annotated by BRENDA team
Usami, N.; Yamamoto, T.; Shintani, S.; Ishikura, S.; Higaki, Y.; Katagiri, Y.; Hara, A.
Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines
Biol. Pharm. Bull.
25
441-445
2002
Homo sapiens
Manually annotated by BRENDA team
Jin, Y.; Cooper, W.C.; Penning, T.M.
Examination of the differences in structure-function of human and rat 3alpha-hydroxysteroid dehydrogenase
Chem. Biol. Interact.
143-144
383-392
2003
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Heredia, V.V.; Kruger, R.G.; Penning, T.M.
Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9)
Chem. Biol. Interact.
143-144
393-400
2003
Rattus norvegicus
Manually annotated by BRENDA team
Rizner, T.L.; Lin, H.K.; Peehl, D.M.; Steckelbroeck, S.; Bauman, D.R.; Penning, T.M.
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells
Endocrinology
144
2922-2932
2003
Homo sapiens
Manually annotated by BRENDA team
Yee, D.J.; Balsanek, V.; Sames, D.
New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3a-hydroxysteroid dehydrogenases
J. Am. Chem. Soc.
126
2282-2283
2004
Comamonas testosteroni, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Steckelbroeck, S.; Jin, Y.; Gopishetty, S.; Oyesanmi, B.; Penning, T.M.
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action
J. Biol. Chem.
279
10784-10795
2004
Homo sapiens, Homo sapiens (Q04828)
Manually annotated by BRENDA team
Ueda, S.; Oda, M.; Imamura, S.; Ohnishi, M.
Steady-state kinetic properties of 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831: Steroid substrate specificity and nucleotide cofactor dependency
J. Biol. Macromol.
4
23-28
2004
Pseudomonas sp., Pseudomonas sp. B-0831
-
Manually annotated by BRENDA team
Gao, C.Q.; Dhooge, W.S.; Kaufman, J.M.; Weyne, J.J.; Eechaute, W.P.
Hypothalamic 5alpha-reductase and 3alpha-oxidoreductase activity in the male rat
J. Steroid Biochem. Mol. Biol.
80
91-98
2002
Rattus norvegicus
Manually annotated by BRENDA team
Lou, Z.; Johnson, J.V.; James, M.O.
Intestinal and hepatic microsomal metabolism of testosterone and progesterone by a 3alpha-hydroxysteroid dehydrogenase to the 3alpha-hydroxy derivatives in the channel catfish, Ictalurus punctatus
J. Steroid Biochem. Mol. Biol.
82
413-424
2002
Ictalurus punctatus
Manually annotated by BRENDA team
Penning, T.M.; Jin, Y.; Heredia, V.V.; Lewis, M.
Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms
J. Steroid Biochem. Mol. Biol.
85
247-255
2003
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Penning, T.M.; Jin, Y.; Steckelbroeck, S.; Lanisnik Rizner, T.; Lewis, M.
Structure-function of human 3alpha-hydroxysteroid dehydrogenases: genes and proteins
Mol. Cell. Endocrinol.
215
63-72
2004
Homo sapiens
Manually annotated by BRENDA team
Steckelbroeck, S.; Jin, Y.; Oyesanmi, B.; Kloosterboer, H.J.; Penning, T.M.
Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: Inversion of stereospecificity with a DELTA5(10)-3-ketosteroid
Mol. Pharmacol.
66
1702-1711
2004
Homo sapiens, Homo sapiens (Q04828)
Manually annotated by BRENDA team
Hwang, C.; Chang, Y.; Hsu, C.; Hsu, H.; Li, C.; Pon, H.
Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni
J. Biol. Chem.
280
3522-3528
2005
Comamonas testosteroni
Manually annotated by BRENDA team
Kataoka, S.; Nakamura, S.; Ohkubo, T.; Ueda, S.; Uchiyama, S.; Kobayashi, Y.; Oda, M.
Crystallization and preliminary X-ray analysis of the complex of NADH and 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831
Acta Crystallogr. Sect. F
62
569-571
2006
Pseudomonas sp., Pseudomonas sp. B-0831
Manually annotated by BRENDA team
Jin, Y.; Penning, T.M.
Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens
Biochemistry
45
13054-13063
2006
Homo sapiens
Manually annotated by BRENDA team
Papari-Zareei, M.; Brandmaier, A.; Auchus, R.J.
Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells
Endocrinology
147
1591-1597
2006
Rattus norvegicus
Manually annotated by BRENDA team
Nakamura, S.; Oda, M.; Kataoka, S.; Ueda, S.; Uchiyama, S.; Yoshida, T.; Kobayashi, Y.; Ohkubo, T.
Apo- and holo-structures of 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831. Loop-helix transition induced by coenzyme binding
J. Biol. Chem.
281
31876-31884
2006
Pseudomonas sp. (Q59718), Pseudomonas sp. B-0831 (Q59718)
Manually annotated by BRENDA team
Okochi, M.; Nakagawa, I.; Kobayashi, T.; Hayashi, S.; Furusaki, S.; Honda, H.
Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (l)-lactate in aqueous phase of biphasic systems for reductive production of steroids
J. Biotechnol.
128
376-382
2006
Comamonas testosteroni
Manually annotated by BRENDA team
Steckelbroeck, S.; Oyesanmi, B.; Jin, Y.; Lee, S.H.; Kloosterboer, H.J.; Penning, T.M.
Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily
J. Pharmacol. Exp. Ther.
316
1300-1309
2006
Homo sapiens
Manually annotated by BRENDA team
Yee, D.J.; Balsanek, V.; Bauman, D.R.; Penning, T.M.; Sames, D.
Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells
Proc. Natl. Acad. Sci. USA
103
13304-13309
2006
Homo sapiens
Manually annotated by BRENDA team
Sanai, M.; Endo, S.; Matsunaga, T.; Ishikura, S.; Tajima, K.; El-Kabbani, O.; Hara, A.
Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol
Arch. Biochem. Biophys.
464
122-129
2007
Rattus norvegicus
Manually annotated by BRENDA team
Uwai, K.; Konno, N.; Yasuta, Y.; Takeshita, M.
Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase
Bioorg. Med. Chem.
16
1084-1089
2008
Rattus norvegicus
Manually annotated by BRENDA team
Cooper, W.C.; Jin, Y.; Penning, T.M.
Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9)
J. Biol. Chem.
282
33484-33493
2007
Rattus norvegicus
Manually annotated by BRENDA team
Chang, Y.H.; Chuang, L.Y.; Hwang, C.C.
Mechanism of proton transfer in the 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni
J. Biol. Chem.
282
34306-34314
2007
Comamonas testosteroni (P80702)
Manually annotated by BRENDA team
Hoffmann, F.; Sotriffer, C.; Evers, A.; Xiong, G.; Maser, E.
Understanding oligomerization in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: an in silico approach and evidence for an active protein
J. Biotechnol.
129
131-139
2007
Comamonas testosteroni (P80702)
Manually annotated by BRENDA team
Azzarello, J.; Fung, K.M.; Lin, H.K.
Tissue distribution of human AKR1C3 and rat homolog in adult genitourinary system
J. Histochem. Cytochem.
56
853-861
2008
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Wang, S.; Yang, Q.; Fung, K.M.; Lin, H.K.
AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells
Mol. Cell. Endocrinol.
289
60-66
2008
Homo sapiens
Manually annotated by BRENDA team
Stayrook, K.R.; Rogers, P.M.; Savkur, R.S.; Wang, Y.; Su, C.; Varga, G.; Bu, X.; Wei, T.; Nagpal, S.; Liu, X.S.; Burris, T.P.
Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha
Mol. Pharmacol.
73
607-612
2008
Homo sapiens
Manually annotated by BRENDA team
Meyer, L.; Venard, C.; Schaeffer, V.; Patte-Mensah, C.; Mensah-Nyagan, A.G.
The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury
Neurobiol. Dis.
30
30-41
2008
Rattus norvegicus
Manually annotated by BRENDA team
Hwang, C.C.; Hsu, C.N.; Huang, T.J.; Chiou, S.J.; Hong, Y.R.
Interactions across the interface contribute the stability of homodimeric 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase
Arch. Biochem. Biophys.
490
36-41
2009
Comamonas testosteroni (P80702)
Manually annotated by BRENDA team
Chang, Y.H.; Huang, T.J.; Chuang, L.Y.; Hwang, C.C.
Role of S114 in the NADH-induced conformational change and catalysis of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni
Biochim. Biophys. Acta
1794
1459-1466
2009
Comamonas testosteroni (P80702)
Manually annotated by BRENDA team
Hidai, C.; Kitano, H.; Kokubun, S.
The Del1 deposition domain can immobilize 3alpha-hydroxysteroid dehydrogenase in the extracellular matrix without interfering with enzymatic activity
Bioprocess Biosyst. Eng.
32
569-573
2009
Homo sapiens, Mus musculus (Q91WR5)
Manually annotated by BRENDA team
Xiong, G.; Draus, E.; Luo, Y.; Maser, E.
3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase as a tool for isolation and characterization of a new marine steroid degrading bacterial strain
Chem. Biol. Interact.
178
206-210
2009
Comamonas testosteroni
Manually annotated by BRENDA team
Xiong, G.; Luo, Y.; Jin, S.; Maser, E.
Cis- and trans-regulatory elements of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase as biosensor system for steroid determination in the environment
Chem. Biol. Interact.
178
215-220
2009
Comamonas testosteroni, Comamonas testosteroni (P80702)
Manually annotated by BRENDA team
Chang, Y.H.; Wang, C.Z.; Chiu, C.C.; Chuang, L.Y.; Hwang, C.C.
Contributions of active site residues to cofactor binding and catalysis of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase
Biochim. Biophys. Acta
1804
235-241
2010
Comamonas testosteroni (P80702)
Manually annotated by BRENDA team
Mundaca, R.A.; Moreno-Guzman, M.; Eguilaz, M.; Yanez-Sedeno, P.; Pingarron, J.M.
Enzyme biosensor for androsterone based on 3alpha-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode
Talanta
99
697-702
2012
Comamonas testosteroni (P80702)
Manually annotated by BRENDA team