1.1.1.50: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

This is an abbreviated version, for detailed information about 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific), go to the full flat file.

Reaction

a 3alpha-hydroxysteroid
+
NAD(P)+
=
a 3-oxosteroid
+
NAD(P)H
+
H+

Synonyms

3 alpha-hydroxysteroid dehydrogenase, 3 alphaHD, 3-alpha-HSD, 3alpha-HSD, 3alpha-HSD/CR, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido-reductase, 3alpha-hydroxysteroid oxidoreductase, 3alpha-hydroxysteroid-5beta-oxidoreductase activity, 3alpha-OR, 3alpha-oxidoreductase, 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, AKR1C, AKR1C1-4, AKR1C17, AKR1C2, AKR1C3, AKR1C4, AKR1C9, aldo-keto reductase 1C2, bile-acid binding protein, chlordecone reductase, DD2, DD21, dihydrodiol dehydrogenase, HSD, HSD28, HSD29, hsdA, HSDH, hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)-dependent 3alpha-HSD, NADPH:5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, prostaglandin F2alpha-synthase, PT3HSD, sterognost 3alpha dehydrogenase, 3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type I 3alpha-HSD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

Turnover Number

Turnover Number on EC 1.1.1.50 - 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.004 - 0.507
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
82
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid
Pseudomonas sp.
-
pH 8.5, 37C, with cofactor NAD+
0.115
(5beta,20R)-20-hydroxypregnan-3-one
Rattus norvegicus
-
pH 7.4, 25C, recombinant wild-type AKR1C17
0.13 - 0.59
1-Acenaphthenol
0.09 - 0.21
1-Indanol
0.0833 - 0.183
3alpha-adiol
-
0.008
3alpha-androstanediol
Homo sapiens
-
pH 7.0, 25C, recombinant enzyme
0.000016 - 0.012
3alpha-hydroxytibolone
0.000016 - 0.016
3beta-hydroxytibolone
1.08
4-Nitrobenzaldehyde
Homo sapiens
-
-
0.0023 - 0.0735
4-pregnen-3alpha,20beta-diol
0.42
5alpha-androstane-3,17-dione
Rattus norvegicus
-
pH 7.0, 25, reduction reaction
0.003 - 0.04
5alpha-dihydroprogesterone
0.0038 - 1
5alpha-dihydrotestosterone
0.047
5beta-androstane-3,17-dione
Rattus norvegicus
-
pH 7.4, 25C, recombinant wild-type AKR1C17
0.0167 - 0.05
5beta-dihydroprogesterone
0.105
5beta-pregnane-3,20-dione
Rattus norvegicus
-
pH 7.4, 25C, recombinant wild-type AKR1C17
0.1
6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one
Rattus norvegicus
-
pH 7.4, 25C, recombinant wild-type AKR1C17
0.183 - 18.9
9,10-phenanthrenequinone
0.00017
allopregnanolone
Homo sapiens
-
pH 7.0, 25C
1.9
androstanedione
Homo sapiens
-
detection spectrophotometrically
0.0018 - 318
androsterone
0.015 - 0.05
benzenedihydrodiol
76
chenodeoxycholic acid
Pseudomonas sp.
-
pH 8.5, 37C, with cofactor NAD+
35 - 75
cholic acid
0.022
Dehydrolithocholic acid
Rattus norvegicus
-
pH 7.4, 25C, recombinant wild-type AKR1C17
0.167
diacetyl
Rattus norvegicus
-
pH 7.4, 25C, recombinant wild-type AKR1C17
23 - 25
Fusidic acid
77
glycocholic acid
Pseudomonas sp.
-
pH 8.5, 37C, with cofactor NAD+
0.283
isatin
Rattus norvegicus
-
pH 7.4, 25C, recombinant wild-type AKR1C17
72
lithocholic acid
Pseudomonas sp.
-
pH 8.5, 37C, with cofactor NAD+
0.02 - 63
NADH
0.00017
NADP+
Homo sapiens
-
pH 7.0, 25C
0.003
NADPH
Homo sapiens
-
pH 7.0, 25C
0.14
oxidized 8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-azabenzo[de]anthracen-10-one
Homo sapiens
-
isozyme AKR1C3
0.0167
stanolone
Homo sapiens
-
-
74
taurocholic acid
Pseudomonas sp.
-
pH 8.5, 37C, with cofactor NAD+
0.0757
testosterone
Homo sapiens
-
-
additional information
additional information
-