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Literature summary for 1.1.1.50 extracted from

  • Cooper, W.C.; Jin, Y.; Penning, T.M.
    Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9) (2007), J. Biol. Chem., 282, 33484-33493.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information steady-state, transient state kinetics, and kinetic isotope effects, kinetic analysis and mechanism, ordered bi-bi mechanism, detailed overview Rattus norvegicus
0.00065
-
5alpha-androstane-3,17-dione pH 7.0, 25, reduction reaction Rattus norvegicus
0.0041
-
androsterone pH 7.0, 25, oxidation reaction Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
androsterone + NADP+ Rattus norvegicus
-
5alpha-androstane-3,17-dione + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ bi bi ordered mechanism, kinetic analysis, overview Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androsterone + NADP+
-
Rattus norvegicus 5alpha-androstane-3,17-dione + NADPH
-
r

Synonyms

Synonyms Comment Organism
3alpha-HSD
-
Rattus norvegicus
AKR1C9
-
Rattus norvegicus
More cf. EC 1.1.1.213, the enzyme is a member of the aldo-keto reductase superfamily Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.42
-
5alpha-androstane-3,17-dione pH 7.0, 25, reduction reaction Rattus norvegicus
0.82
-
androsterone pH 7.0, 25, oxidation reaction Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+ loose association of the NADP(H) is followed by two conformational changes, which increases cofactor affinity by 86fold Rattus norvegicus
NADPH loose association of the NADP(H) is followed by two conformational changes, which increases cofactor affinity by 86fold Rattus norvegicus