Reference on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter and Organism(s) Homo sapiens and UniProt Accession O15440
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Sharma, R.; Singhal, S.; Cheng, J.; Yang, Y.; Sharma, A.; Zimniak, P.; Awasthi, S.; Awasthi, Y.
RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes
Arch. Biochem. Biophys.
391
171-179
2001
Homo sapiens (Q15311), Homo sapiens
Hessel, S.; John, A.; Seidel, A.; Lampen, A.
Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells
Arch. Toxicol.
87
269-280
2013
Homo sapiens (O15438), Homo sapiens (P33527), Homo sapiens (Q92887), Homo sapiens (Q9UNQ0)
Zhang, Y.; Callaway, E.
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate
Biochem. J.
364
301-307
2002
Homo sapiens (Q8HXQ5), Homo sapiens
Karwatsky, J.; Daoud, R.; Cai, J.; Gros, P.; Georges, E.
Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17
Biochemistry
42
3286-3294
2003
Homo sapiens (P33527)
Peklak-Scott, C.; Townsend, A.; Morrow, C.
Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide Contributions of glutathione, glutathione S-transferase, and MRP1
Biochemistry
44
4426-4433
2005
Homo sapiens
Schmitt, S.M.; Stefan, K.; Wiese, M.
Pyrrolopyrimidine derivatives and purine analogs as novel activators of multidrug resistance-associated protein 1 (MRP1, ABCC1)
Biochim. Biophys. Acta
1859
69-79
2017
Homo sapiens (P33527), Canis lupus familiaris (Q6UR05)
Homolya, L.; Varadi, A.; Sarkadi, B.
Multidrug resistance-associated proteins Export pumps for conjugates with glutathione, glucuronate or sulfate
Biofactors
17
103-114
2003
Homo sapiens (O15439), Homo sapiens (O15440), Homo sapiens (O95255), Homo sapiens (P33527), Homo sapiens (Q92887)
Keppler, D.; Leier, I.; Jedlitschky, G.
Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2
Biol. Chem.
378
787-791
1997
Homo sapiens (Q92887), Homo sapiens
Renes, J.; De Vries, E.; Nienhuis, E.; Jansen, P.; Mueller, M.
ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1
Br. J. Pharmacol.
126
681-688
1999
Homo sapiens (P33527)
Awasthi, Y.; Singhal, S.; Zimniak, P.; Piper, J.; Pikula, S.; Bandorowicz-Pikula, J.; Lin, J.; Srivastava, S.; Singh, S.; Awasthi, S.
Glutathione-linked pathways in drug resistance Characterization and functional reconstitution of human erythrocyte glutathione-conjugate transporter
Clin. Chem. Enzymol. Commun.
8
431-448
1999
Homo sapiens
-
Vaidya, S.; Walsh, S.; Gerk, P.
Application of human placental villous tissue explants to study ABC transporter mediated efflux of 2,4-dinitrophenyl-S-glutathione
Curr. Pharm. Biotechnol.
12
814-823
2011
Homo sapiens (Q92887), Homo sapiens
Cool, R.; Veenstra, M.; Van Klompenburg, W.; Heyne, R.; Mueller, M.; De Vries, E.; Van Veen, H.; Konings, W.
S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1)
Eur. J. Biochem.
269
3470-3478
2002
Homo sapiens (P33527)
-
Zamek-Gliszczynski, M.; Hoffmaster, K.; Nezasa, K.; Tallman, M.; Brouwer, K.
Integration of hepatic drug transporters and phase II metabolizing enzymes Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
Eur. J. Pharm. Sci.
27
447-486
2006
Mus musculus, Mus musculus (P04095), Mus musculus (Q7TMS5), Mus musculus (Q8VI47), Homo sapiens (O15438), Homo sapiens (O15439), Homo sapiens (Q92887), Homo sapiens (Q9UNQ0), Rattus norvegicus (Q63120), Rattus norvegicus (Q6QMG6), Rattus norvegicus (Q80W57), Rattus norvegicus (Q88563)
Deeley, R.; Cole, S.
Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
FEBS Lett.
580
1103-1111
2006
Homo sapiens (P08183)
Fallatah, O.; Georges, E.
Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum
Int. J. Antimicrob. Agents
50
673-677
2017
Homo sapiens (P08183)
Van Luyn, M.; Muller, M.; Renes, J.; Meijer, C.; Scheper, R.; Nienhuis, E.; Mulder, N.; Jansen, P.; De Vries, E.
Transport of glutathione conjugates into secretory vesicles is mediated by the multidrug-resistance protein 1
Int. J. Cancer
76
55-62
1998
Homo sapiens (P33527), Homo sapiens
Manciu, L.; Chang, X.; Buyse, F.; Hou, Y.; Gustot, A.; Riordani, J.; Ruysschaert, J.
Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione
J. Biol. Chem.
278
3347-3356
2003
Homo sapiens (P33527)
Leslie, E.; Haimeur, A.; Waalkes, M.
Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1) Evidence that a tri-glutathione conjugate is required
J. Biol. Chem.
279
32700-32708
2004
Homo sapiens (P33527), Homo sapiens (Q92887)
Cole, S.
Multidrug resistance protein 1 (MRP1, ABCC1), a multitasking ATP-binding cassette (ABC,) transporter
J. Biol. Chem.
289
30880-30888
2014
Homo sapiens (P33527)
Ballatori, N.; Krance, S.; Marchan, R.; Hammond, C.
Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology
Mol. Aspects Med.
30
13-28
2009
Homo sapiens, Homo sapiens (O95255), Homo sapiens (P33527), Homo sapiens (Q15439), Homo sapiens (Q15440), Homo sapiens (Q92887)
Vaidya, S.; Walsh, S.; Gerk, P.
Formation and efflux of ATP-binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments
Mol. Pharm.
6
1689-1702
2009
Homo sapiens (P33527), Homo sapiens (Q92887)
Morrow, C.; Peklak-Scott, C.; Bishwokarma, B.; Kute, T.; Smitherman, P.; Townsend, A.
Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux
Mol. Pharmacol.
69
1499-1505
2006
Homo sapiens (P33527)
Koley, D.; Bard, A.
Inhibition of the MRP1-mediated transport of the menadione-glutathione conjugate (thiodione) in HeLa cells as studied by SECM
Proc. Natl. Acad. Sci. USA
109
11522-11527
2012
Homo sapiens (P33527)
Hong, Y.; Lai, Y.; Chan, G.; Sun, H.
Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells
Proc. Natl. Acad. Sci. USA
112
3211-3216
2015
Homo sapiens
Ballatori, N.; Hammond, C.; Cunningham, J.; Krance, S.; Marchan, R.
Molecular mechanisms of reduced glutathione transport Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
Toxicol. Appl. Pharmacol.
204
238-255
2005
Saccharomyces cerevisiae, Rattus norvegicus, Homo sapiens (O15439), Homo sapiens (O15440), Homo sapiens (P33527), Homo sapiens (Q92887), Homo sapiens