Reference on EC 5.2.1.8 - peptidylprolyl isomerase and Organism(s) Homo sapiens and UniProt Accession Q9UNP9
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Harding, M.W.; Handschumacher, R.E.; Speicher, D.W.
Isolation and amino acid sequence of cyclophilin
J. Biol. Chem.
261
8547-8555
1986
Bos taurus, Homo sapiens
Schutkowski, M.; Wllner, S.; Fischer, G.
Inhibition of peptidyl-prolyl cis/trans isomerase activity by substrate analog structures: thioxo tetrapeptide-4-nitroanilides
Biochemistry
34
13016-13026
1995
Homo sapiens
Levy, M.A.; Brandt, M.; Livi, G.P.; Bergsma, D.J.
Purification and characterization of human T-cell cyclophilin expressed in Escherichia coli
Transplant. Proc.
23
319-322
1991
Homo sapiens
Huss, R.
Inhibition of cyclophilin function in HIV-I infection by cyclosporin A
Trends Immunol.
17
259-260
1996
Homo sapiens
Schmidt, B.; Tradler, T.; Rahfeld, J.U.; Ludwig, B.; Jain, B.; Mann, K.; Rucknagel, K.P.; Janowski, B.; Schierhorn, A.; Kullertz, G.; Hacker, J.M.; Fischer, G.
A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila - characterization, molecular cloning and overexpression
Mol. Microbiol.
21
1147-1160
1996
Homo sapiens, Legionella pneumophila
Kofron, J.L.; Kuzmic, P.; Kishore, V.; Gemmecker, G.; Fesik, S.W.; Rich, D.H.
Lithium chloride pertubation of cis-trans peptide bond equilibria: effect on conformational equilibria in cyclosporin A and on time-dependent inhibition of cyclophilin
J. Am. Chem. Soc.
114
2670-2675
1992
Homo sapiens
-
Holzman, T.F.; Egan, D.A.; Edalji, R.; Simmer, R.L.; Helfrich, R.; Taylor, A.; Burres, N.S.
Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin
J. Biol. Chem.
266
2474-2479
1991
Homo sapiens
Bergsma, D.J.; Eder, C.; Gross, M.; Kersten, H.; Sylvester, D.; Appelbaum, E.; Cusimano, D.; Livi, G.P.; McLaughlin, M.M.; Kasyan, K.; Porter, T.G.; Silverman, C.; Dunnington, D.; Hand, A.; Prichett, W.P.; Bossard, M.J.; Brandt, M.; Levy, M.A.
The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms
J. Biol. Chem.
266
23204-23214
1991
Homo sapiens
Liu, J.; Albers, M.W.; Chen, C.M.; Schreiber, S.L.; Walsh, C.T.
Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis
Proc. Natl. Acad. Sci. USA
87
2304-2308
1990
Homo sapiens
Vajdos, F.F.; Yoo, S.; Houseweart, M.; Sundquist, W.I.; Hill, C.P.
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein
Protein Sci.
6
2297-2307
1997
Homo sapiens
Gamble, T.R.; Vajdos, F.F.; Yoo, S.; Worthylake, D.K.; Houseweart, M.; Sundquist, W.I.; Hill, C.P.
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid
Cell
87
1285-1294
1996
Homo sapiens (P62937), Homo sapiens
Ke, H.; Mayrose, D.; Belshaw, P.J.; Alberg, D.G.; Schreiber, S.L.; Chang, Z.Y.; Etzkorn, F.A.; Ho, S.; Walsh, C.T.
Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
Structure
2
33-44
1994
Homo sapiens
Mikol, V.; Kallen, J.; Pfugl, G.; Walkinshaw, M.D.
X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 A resolution
J. Mol. Biol.
234
1119-1130
1993
Homo sapiens
Pflugl, G.; Kallen, J.; Schirmer, T.; Jansonius, J.N.; Zurini, M.G.; Walkinshaw, M.D.
X-ray structure of a decameric cyclophilin-cyclosporin crystal complex
Nature
361
91-94
1993
Homo sapiens
Ke, H.M.; Zydowski, L.D.; Liu, J.; Walsh, C.T.
Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution
Proc. Natl. Acad. Sci. USA
88
9483-9487
1991
Homo sapiens
Kallen, J.; Spitzfaden, C.; Zurini, M.G.; Wider, G.; Widmer, H.; Wuthrich, K.; Walkinshaw, M.D.
Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
Nature
353
276-279
1991
Homo sapiens
Zurini, M.; Kallen, J.; Mikol, V.; Pfluegel, G.; Jansonius, J.N.; Walkinshaw, M.D.
Crystallisation and preliminary X-ray diffraction studies of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexes
FEBS Lett.
276
63-66
1990
Homo sapiens
Zydowsky, L.D.; Etzkorn, F.A.; Chang, H.Y.; Ferguson, S.B.; Stolz, L.A.; Ho, S.I.; Walsh, C.T.
Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition
Protein Sci.
1
1092-1099
1992
Homo sapiens
Hennig, L.; Christner, C.; Kipping, M.; Schelbert, B.; Rucknagel, K.P.; Grabley, S.; Kullertz, G.; Fischer, G.
Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone
Biochemistry
37
5953-5960
1998
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
Zhang, Y.; Fuessel, S.; Reimer, U.; Schutkowski, M.; Fischer, G.
Substrate-based design of reversible Pin1 inhibitors
Biochemistry
41
11868-11877
2002
Homo sapiens
Demange, L.; Moutiez, M.; Vaudry, K.; Dugave, C.
Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites
FEBS Lett.
505
191-195
2001
Homo sapiens
Bayer, E.; Goettsch, S.; Mueller, J.W.; Griewel, B.; Guiberman, E.; Mayr, L.M.; Bayer, P.
Structural analysis of the mitotic regulator hPin1 in solution. insights into domain architecture and substrate binding
J. Biol. Chem.
278
26183-26193
2003
Homo sapiens (Q13526)
Terada, T.; Shirouzu, M.; Fukumori, Y.; Fujimori, F.; Ito, Y.; Kigawa, T.; Yokoyama, S.; Uchida, T.
Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14
J. Mol. Biol.
305
917-926
2001
Homo sapiens (Q13526), Homo sapiens
Pirkl, F.; Buchner, J.
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40
J. Mol. Biol.
308
795-806
2001
Homo sapiens
Lavoie, S.B.; Albert, A.L.; Handa, H.; Vincent, M.; Bensaude, O.
The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9
J. Mol. Biol.
312
675-685
2001
Homo sapiens
Reimer, T.; Weiwad, M.; Schierhorn, A.; Ruecknagel, P.K.; Rahfeld, J.U.; Bayer, P.; Fischer, G.
Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14
J. Mol. Biol.
330
955-966
2003
Homo sapiens
Reidt, U.; Wahl, M.C.; Fasshauer, D.; Horowitz, D.S.; Luhrmann, R.; Ficner, R.
Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide
J. Mol. Biol.
331
45-56
2003
Homo sapiens
Brazin, K.N.; Mallis, R.J.; Fulton, D.B.; Andreotti, A.H.
Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A
Proc. Natl. Acad. Sci. USA
99
1899-1904
2002
Homo sapiens
Golbik, R.; Fischer, G.; Fersht, A.R.
Folding of barstar C40A/C82A/P27A and catalysis of the peptidyl-prolyl cis/trans isomerization by human cytosolic cyclophilin (Cyp18)
Protein Sci.
8
1505-1514
1999
Homo sapiens
Carpentier, M.; Allain, F.; Haendler, B.; Slomianny, M.C.; Spik, G.
Delineation of the calcineurin-interacting region of cyclophilin B
Protein Sci.
9
2386-2393
2000
Homo sapiens
Huang, L.L.; Zhao, X.M.; Huang, C.Q.; Yu, L.; Xia, Z.X.
Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family
Acta Crystallogr. Sect. D
D61
316-321
2005
Homo sapiens
Hu, H.; Huang, C.Q.; Liu, H.L.; Han, Y.; Yu, L.; Bi, R.C.
Crystallization and preliminary x-ray crystallographic studies of human cyclophilin J
Acta Crystallogr. Sect. F
F61
216-218
2005
Homo sapiens (Q9H2H8), Homo sapiens
Wang, T.; Yun, C.H.; Gu, S.Y.; Chang, W.R.; Liang, D.C.
1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase
Biochem. Biophys. Res. Commun.
333
845-849
2005
Homo sapiens
Agarwal, P.K.; Geist, A.; Gorin, A.
Protein dynamics and enzymatic catalysis: investigating the peptidyl-prolyl cis-trans isomerization activity of cyclophilin A
Biochemistry
43
10605-10618
2004
Homo sapiens (P62937), Homo sapiens
Smet, C.; Wieruszeski, J.M.; Buee, L.; Landrieu, I.; Lippens, G.
Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein
FEBS Lett.
579
4159-4164
2005
Homo sapiens
Jordens, J.; Janssens, V.; Longin, S.; Stevens, I.; Martens, E.; Bultynck, G.; Engelborghs, Y.; Lescrinier, E.; Waelkens, E.; Goris, J.; Van Hoof, C.
The PP2A phosphatase activator (PTPA) is a novel peptidyl-prolyl cis/trans isomerase
J. Biol. Chem.
281
6349-6357
2005
Saccharomyces cerevisiae, Oryctolagus cuniculus, Homo sapiens
Watashi, K.; Ishii, N.; Hijikata, M.; Inoue, D.; Murata, T.; Miyanari, Y.; Shimotohno, K.
Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase
Mol. Cell
19
111-122
2005
Homo sapiens
Yi, P.; Wu, R.C.; Sandquist, J.; Wong, J.; Tsai, S.Y.; Tsai, M.J.; Means, A.R.; O'Malley, B.W.
Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1)
Mol. Cell. Biol.
25
9687-9699
2005
Homo sapiens
Dourlen, P.; Ando, K.; Hamdane, M.; Begard, S.; Buee, L.; Galas, M.C.
The peptidyl prolyl cis/trans isomerase Pin1 downregulates the inhibitor of apoptosis protein Survivin
Biochim. Biophys. Acta
1773
1428-1437
2007
Homo sapiens (Q13526)
Dubowchik, G.M.; Ditta, J.L.; Herbst, J.J.; Bollini, S.; Vitnitsky, A.
Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay
Bioorg. Med. Chem. Lett.
10
559-562
2000
Homo sapiens
Halt, D.A.; Konialian-Beck, A.L.; Oh, H.J.; Yen, H.K.; Rozamus, L.W.; Krog, A.J.; Erhard, K.F.; Ortiz, E.; Levy, M.A.; Brandt, M.; Bossard, M.; Luengo, J.I.
Structure-activity studies of synthetic FKBP ligands as peptidyl-prolyl isomerase inhibitors
Bioorg. Med. Chem. Lett.
4
315-322
1994
Homo sapiens
-
Luengo, J.I.; Konialian-Beck, A.; Levy, M.A.; Brandt, M.; Eggleston, D.S.; Holt, D.A.
Synthesis and structure-activity relationship of macrocyclic FKBP ligands
Bioorg. Med. Chem. Lett.
4
321-324
1994
Homo sapiens
-
Yamashita, D.S.; Oh, H.J.; Yen, H.K.; Bossard, M.J.; Brandt, M.; Levy, M.A.; Newman-Tarr,T.; Badger,A.; Luengo J.I.; Halt, D.A.
Design, synthesis and evaluation of dual domain FKBP ligands
Bioorg. Med. Chem. Lett.
4
325-328
1994
Homo sapiens
-
Babine, R.E.; Bleckman, T.M.; Kissinger, C.R.; Showalter, R.; Pelletier, L.A.; Lewis, C.; Tucker, K.; Moomaw, E.; Parge H.E.; Villafranca, J.E.
Design, synthesis and X-ray crystallographic studies of novel FKBP-12 ligands
Bioorg. Med. Chem. Lett.
5
1719-1724
1995
Homo sapiens
-
Tatlock, J.H.; Kalish, V.j.; Parge, H.E.; Knighton, D.R.; Showalter, R.E.; Lewis, C.T.; French, J.V.; Villafranca, J.E.
High-affinity FKBP-12 ligands derived from (R)-(-)-carvone. Synthesis and evaluation of FK506 pyranose ring replacements
Bioorg. Med. Chem. Lett.
5
2489-2492
1995
Homo sapiens
-
Babine, R.E.; Bleckman, T.M.; Littlefield, E.S.; Parge, H.E.; Pelletier, L.A.K.; Lewis, C.T.; French, J.V.; Imbacuan, M.; Katoh, S.; Tatlock, J.H.; Showalter, R.E.; Villafranca, J.E.
Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands
Bioorg. Med. Chem. Lett.
6
385-390
1996
Homo sapiens (P62942)
-
Wang, X.J.; Etzkorn, F.A.
Peptidyl-prolyl isomerase inhibitors
Biopolymers
84
125-146
2006
Homo sapiens
Obama, K.; Kato, T.; Hasegawa, S.; Satoh, S.; Nakamura, Y.; Furukawa, Y.
Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells
Clin. Cancer Res.
12
70-76
2006
Homo sapiens
Siegrist, R.; Zurcher, M.; Baumgartner, C.; Seiler, P.; Diederich, F.; Daum, S.; Fischer, G.; Klein, C.; Dangl, M.; Schwaiger, M.
A novel synthesis of highly substituted perhydropyrrolizines, perhydroindolizines, and pyrrolidines: inhibition of the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1
Helv. Chim. Acta
90
217-259
2007
Homo sapiens (Q13526)
-
Holt, D.A.; Luengo, J.I.; Yamashita, D.S.; Oh, H.J.; Konialian, A.L.; Yen, H.K.; Rozamus, L.W.; Brandt, M.; Bossard, M.J.; Levy, m.A.; Eggleston, D.S.; g Liang, J.; Schultz, L.W.; Stout, t.J.; Clardyt, J.
Design, synthesis and kinetic evaluation of high-affinity FKBP ligands and the X-ray Crystal structures of their complexes with FKBP12
J. Am. Chem. Soc.
115
9925-9938
1993
Homo sapiens
-
Xu, C.; Zhang, J.; Huang, X.; Sun, J.; Xu, Y.; Tang, Y.; Wu, J.; Shi, Y.; Huang, Q.; Zhang, Q.
Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP
J. Biol. Chem.
281
15900-15908
2006
Homo sapiens (Q9Y3C6), Homo sapiens
Yu, L.; Mohamed, A.J.; Vargas, L.; Bergloef, A.; Finn, G.; Lu, K.P.; Smith, C.I.
Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1
J. Biol. Chem.
281
18201-18207
2006
Homo sapiens (Q13526), Homo sapiens
Esnault, S.; Shen, Z.J.; Whitesel, E.; Malter, J.S.
The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes
J. Immunol.
177
6999-7006
2006
Homo sapiens (Q13526), Homo sapiens
Christner, C.; Wyrwa, R.; Marsch, S.; Kullertz, G.; Thiericke, R.; Grabley, S.; Schumann, D.; Fischer, G.
Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neurogenerative properties
J. Med. Chem.
42
3615-3622
1999
Homo sapiens
Demange, L.; Moutiez, M.; Dugave, C.
Synthesis and evaluation of Glypsi(PO2R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18
J. Med. Chem.
45
3928-3933
2002
Homo sapiens
Wu, Y-Q.; Belyakov, S.; choi, c.; Limburg, D.; thomas, b.E.; Vaal, m.; Wei, L.; Wilkinson, D.E.; Holmes, A.; Fuller, M.; McCormick, J.; Conolly, M.; Moeller, T.; Steiner, J.; Hamilton, G.S.
Synthesis and biological evaluation of non-peptidic cyclophilin ligands
J. Med. Chem.
46
1112-1115
2003
Homo sapiens
Wildemann, D.; Erdmann, F.; Alvarez, B.H.; Stoller, G.; Zhou, X.Z.; Fanghaenel, J.; Schutkowski, M.; Lu, K.P.; Fischer, G.
Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries
J. Med. Chem.
49
2147-2150
2006
Homo sapiens
Behrsin, C.D.; Bailey, M.L.; Bateman, K.S.; Hamilton, K.S.; Wahl, L.M.; Brandl, C.J.; Shilton, B.H.; Litchfield, D.W.
Functionally important residues in the peptidyl-prolyl isomerase Pin1 revealed by unigenic evolution
J. Mol. Biol.
365
1143-1162
2007
Homo sapiens (Q13526), Homo sapiens
Andres, C.J.; Macdonald, T.L.
Conformationally defined analogs of prolylamides. trans-Prolyl peptidomimetics
J. Org. Chem.
58
6609-6613
1993
Homo sapiens
-
Barth, S.; Nesper, J.; Hasgall, P.A.; Wirthner, R.; Nytko, K.J.; Edlich, F.; Katschinski, D.M.; Stiehl, D.P.; Wenger, R.H.; Camenisch, G.
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability
Mol. Cell. Biol.
27
3758-3768
2007
Homo sapiens (Q14318)
Dubowchik, G.M.; Vrudhula, V.M.; Dasgupta, B.; Ditta, J.; Chen, T.; Sheriff, S.; Sipman, K.; Witmer, M.; Tredup, J.; Vyas, d.M.; Verdoorn, T.A.; Bollini, S.; Vinitsky, A.
2-aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies
Org. Lett.
3
3987-3990
2001
Homo sapiens
Kim, M.R.; Choi, H.S.; Heo, T.H.; Hwang, S.W.; Kang, K.W.
Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells
Biochem. Biophys. Res. Commun.
369
547-553
2008
Homo sapiens
Bailey, M.L.; Shilton, B.H.; Brandl, C.J.; Litchfield, D.W.
The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role
Biochemistry
47
11481-11489
2008
Homo sapiens
Xu, L.R.; Yan, X.; Luo, M.; Guan, Y.X.; Yao, S.J.
Preparation, characterization and refolding in vitro of a recombinant human cyclophilin A mutant: effect of a single Pro/Ser substitution on cyclophilin A structure and properties
Biotechnol. Prog.
24
302-310
2008
Homo sapiens
Brenkman, A.B.; de Keizer, P.L.; van den Broek, N.J.; van der Groep, P.; van Diest, P.J.; van der Horst, A.; Smits, A.M.; Burgering, B.M.
The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors
Cancer Res.
68
7597-7605
2008
Homo sapiens
Zheng, J.; Koblinski, J.E.; Dutson, L.V.; Feeney, Y.B.; Clevenger, C.V.
Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer
Cancer Res.
68
7769-7778
2008
Homo sapiens
Davis, T.L.; Walker, J.R.; Ouyang, H.; MacKenzie, F.; Butler-Cole, C.; Newman, E.M.; Eisenmesser, E.Z.; Dhe-Paganon, S.
The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1)
FEBS J.
275
2283-2295
2008
Homo sapiens (Q96BP3), Homo sapiens
Stumpf, T.; Zhang, Q.; Hirnet, D.; Lewandrowski, U.; Sickmann, A.; Wissenbach, U.; Doerr, J.; Lohr, C.; Deitmer, J.W.; Fecher-Trost, C.
The human TRPV6 channel protein is associated with cyclophilin B in human placenta
J. Biol. Chem.
283
18086-18098
2008
Homo sapiens
Rudrabhatla, P.; Zheng, Y.L.; Amin, N.D.; Kesavapany, S.; Albers, W.; Pant, H.C.
Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein
J. Biol. Chem.
283
26737-26747
2008
Homo sapiens (Q13526)
Braun, M.; Hessamian-Alinejad, A.; de Lacroix, B.F.; Alvarez, B.H.; Fischer, G.
Novel spiroannulated 3-benzofuranones. Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1
Molecules
13
995-1003
2008
Homo sapiens
Buschdorf, J.P.; Chew, L.L.; Soh, U.J.; Liou, Y.C.; Low, B.C.
Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons
PLoS ONE
3
e2686
2008
Homo sapiens
Fan, G.; Fan, Y.; Gupta, N.; Matsuura, I.; Liu, F.; Zhou, X.Z.; Lu, K.P.; Gelinas, C.
Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family
Cancer Res.
69
4589-4597
2009
Homo sapiens
van der Horst, A.; Khanna, K.K.
The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55
Cancer Res.
69
6651-6659
2009
Homo sapiens
Rudrabhatla, P.; Pant, H.C.
Phosphorylation-specific peptidyl-prolyl isomerization of neuronal cytoskeletal proteins by Pin1: implications for therapeutics in neurodegeneration
J. Alzheimers Dis.
19
389-403
2010
Homo sapiens, Rattus norvegicus
Hanoulle, X.; Badillo, A.; Wieruszeski, J.M.; Verdegem, D.; Landrieu, I.; Bartenschlager, R.; Penin, F.; Lippens, G.
Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B
J. Biol. Chem.
284
13589-13601
2009
Homo sapiens
Liu, T.; Liu, Y.; Kao, H.Y.; Pei, D.
Membrane permeable cyclic peptidyl inhibitors against human peptidylprolyl isomerase Pin1
J. Med. Chem.
53
2494-2501
2010
Homo sapiens
Rudrabhatla, P.; Albers, W.; Pant, H.C.
Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins
J. Neurosci.
29
14869-14880
2009
Homo sapiens, Rattus norvegicus
Peloponese, J.M.; Yasunaga, J.; Kinjo, T.; Watashi, K.; Jeang, K.T.
Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB
J. Virol.
83
3238-3248
2009
Homo sapiens
Liu, Z.; Yang, F.; Robotham, J.M.; Tang, H.
Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex
J. Virol.
83
6554-6565
2009
Homo sapiens
Fujiyama-Nakamura, S.; Yoshikawa, H.; Homma, K.; Hayano, T.; Tsujimura-Takahashi, T.; Izumikawa, K.; Ishikawa, H.; Miyazawa, N.; Yanagida, M.; Miura, Y.; Shinkawa, T.; Yamauchi, Y.; Isobe, T.; Takahashi, N.
Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage
Mol. Cell. Proteomics
8
1552-1565
2009
Homo sapiens, Mus musculus
Shen, Z.J.; Esnault, S.; Schinzel, A.; Borner, C.; Malter, J.S.
The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
Nat. Immunol.
10
257-265
2009
Homo sapiens
Liao, Y.; Wei, Y.; Zhou, X.; Yang, J.Y.; Dai, C.; Chen, Y.J.; Agarwal, N.K.; Sarbassov, D.; Shi, D.; Yu, D.; Hung, M.C.
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
Oncogene
28
2436-2445
2009
Homo sapiens
Misumi, S.; Inoue, M.; Dochi, T.; Kishimoto, N.; Hasegawa, N.; Takamune, N.; Shoji, S.
Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase Pin1
J. Biol. Chem.
285
25185-25195
2010
Homo sapiens
Nakatsu, Y.; Sakoda, H.; Kushiyama, A.; Zhang, J.; Ono, H.; Fujishiro, M.; Kikuchi, T.; Fukushima, T.; Yoneda, M.; Ohno, H.; Horike, N.; Kanna, M.; Tsuchiya, Y.; Kamata, H.; Nishimura, F.; Isobe, T.; Ogihara, T.; Katagiri, H.; Oka, Y.; Takahashi, S.; Kurihara, H.; Uchida, T.; Asano, T.
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis
J. Biol. Chem.
286
20812-20822
2011
Homo sapiens, Mus musculus
St-Denis, N.A.; Bailey, M.L.; Parker, E.L.; Vilk, G.; Litchfield, D.W.
Localization of phosphorylated CK2alpha to the mitotic spindle requires the peptidyl-prolyl isomerase Pin1
J. Cell Sci.
124
2341-2348
2011
Homo sapiens
Duncan, K.E.; Dempsey, B.R.; Killip, L.E.; Adams, J.; Bailey, M.L.; Lajoie, G.A.; Litchfield, D.W.; Brandl, C.J.; Shaw, G.S.; Shilton, B.H.
Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1
J. Med. Chem.
54
3854-3865
2011
Homo sapiens
Lim, Y.S.; Tran, H.T.; Park, S.J.; Yim, S.A.; Hwang, S.B.
Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation
J. Virol.
85
8777-8888
2011
Homo sapiens
Davis, T.L.; Walker, J.R.; Campagna-Slater, V.; Finerty, P.J.; Paramanathan, R.; Bernstein, G.; MacKenzie, F.; Tempel, W.; Ouyang, H.; Lee, W.H.; Eisenmesser, E.Z.; Dhe-Paganon, S.
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases
PLoS Biol.
8
e1000439
2010
Homo sapiens (O43447), Homo sapiens (P23284), Homo sapiens (P30405), Homo sapiens (P45877), Homo sapiens (P62937), Homo sapiens (Q08752), Homo sapiens (Q13427), Homo sapiens (Q6UX04), Homo sapiens (Q9UNP9), Homo sapiens
Mercedes-Camacho, A.Y.; Mullins, A.B.; Mason, M.D.; Xu, G.G.; Mahoney, B.J.; Wang, X.; Peng, J.W.; Etzkorn, F.A.
Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase
Biochemistry
52
7707-7713
2013
Homo sapiens (Q13526)
Hediger, T.; Frank, W.; Schumann, M.; Fischer, G.; Braun, M.
Aryl hetaryl ketones and thioketones as efficient inhibitors of peptidyl-prolyl cis-trans isomerases
Chem. Biodivers.
9
2618-2634
2012
Homo sapiens
Ikura, T.; Ito, N.
Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating
Protein Eng. Des. Sel.
26
539-546
2013
Homo sapiens
Boudko, S.P.; Ishikawa, Y.; Nix, J.; Chapman, M.S.; Baechinger, H.P.
Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs
Protein Sci.
23
67-75
2014
Homo sapiens (Q9NWM8), Homo sapiens
Ulrich, A.; Wahl, M.C.
Structure and evolution of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27
Acta Crystallogr. Sect. D
70
3110-3123
2014
Homo sapiens (Q6UX04), Homo sapiens, Thermochaetoides thermophila (G0RY38), Thermochaetoides thermophila DSM 1495 (G0RY38)
Hidaka, M.; Kosaka, K.; Tsushima, S.; Uchida, C.; Takahashi, K.; Takahashi, N.; Tsubuki, M.; Hara, Y.; Uchida, T.
Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1
Biochem. Biophys. Res. Commun.
499
681-687
2018
Homo sapiens (Q13526)
Ettelaie, C.; Collier, M.E.W.; Featherby, S.; Greenman, J.; Maraveyas, A.
Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles
Biochim. Biophys. Acta
1865
12-24
2018
Homo sapiens (Q13526)
Jalouli, M.; Dery, M.A.; Lafleur, V.N.; Lamalice, L.; Zhou, X.Z.; Lu, K.P.; Richard, D.E.
The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity
Cell. Signal.
26
1649-1656
2014
Homo sapiens (Q13526)
Jiang, Q.; Li, X.R.; Wang, C.K.; Cheng, J.; Tan, C.; Cui, T.T.; Lu, N.N.; James, T.D.; Han, F.; Li, X.
A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells
Chem. Commun. (Camb.)
54
1857-1860
2018
Homo sapiens (Q00688)
Chen, J.; Chen, S.; Wang, J.; Zhang, M.; Gong, Z.; Wei, Y.; Li, L.; Zhang, Y.; Zhao, X.; Jiang, S.; Yu, L.
Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma
PLoS ONE
10
e0127668
2015
Homo sapiens
Han, H.J.; Kwon, N.; Choi, M.A.; Jung, K.O.; Piao, J.Y.; Ngo, H.K.; Kim, S.J.; Kim, D.H.; Chung, J.K.; Cha, Y.N.; Youn, H.; Choi, B.Y.; Min, S.H.; Surh, Y.J.
Peptidyl prolyl isomerase PIN1 directly binds to and stabilizes hypoxia-inducible factor-1alpha
PLoS ONE
11
e0147038
2016
Homo sapiens (Q13526), Mus musculus (Q9QUR7)
