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Literature summary for 5.2.1.8 extracted from

  • Mercedes-Camacho, A.Y.; Mullins, A.B.; Mason, M.D.; Xu, G.G.; Mahoney, B.J.; Wang, X.; Peng, J.W.; Etzkorn, F.A.
    Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase (2013), Biochemistry, 52, 7707-7713.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Protein Variants

Protein Variants Comment Organism
additional information mutation of active site residues of Pin1 results in weakened, but not total, abrogation of activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic analysis of Pin1, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Pin1 is a peptidyl-prolyl isomerase (PPIase), that catalyzes the cis-trans isomerization of pSer/pThr-Pro substrates in vivo and in vitro ?
-
 ?
peptidylproline (omega=180) Homo sapiens
-
 peptidylproline (omega=0)
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13526
-
-

Reaction

Reaction Comment Organism Reaction ID
peptidylproline (omega=180) = peptidylproline (omega=0) simple twisted amide transition state catalytic mechanism, modeling, overview. The serine carbonyl does not rehybridize from sp2 to sp3 in the rate-determining step, ruling out a nucleophilic addition mechanism Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Pin1 is a peptidyl-prolyl isomerase (PPIase), that catalyzes the cis-trans isomerization of pSer/pThr-Pro substrates in vivo and in vitro Homo sapiens ?
-
 ?
peptidylproline (omega=180)
-
 Homo sapiens peptidylproline (omega=0)
-
 ?
Phe-Phe-L-pSer-Pro-Arg-pNA
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
NIMA-1
-
 Homo sapiens
Pin1
-
 Homo sapiens

General Information

General Information Comment Organism
additional information active site Cys113 Homo sapiens