Literature summary for 5.2.1.8 extracted from

Han, H.J.; Kwon, N.; Choi, M.A.; Jung, K.O.; Piao, J.Y.; Ngo, H.K.; Kim, S.J.; Kim, D.H.; Chung, J.K.; Cha, Y.N.; Youn, H.; Choi, B.Y.; Min, S.H.; Surh, Y.J.
Peptidyl prolyl isomerase PIN1 directly binds to and stabilizes hypoxia-inducible factor-1alpha (2016), PLoS ONE, 11, e0147038 .

Search for more literature for 5.2.1.8

Application

Application	Comment	Organism
medicine	PIN1 inhibition dramatically reduces the tumor volume in a subcutaneous mouse xenograft model and angiogenesis as well as hypoxia-induced transcriptional activity of hypoxia-inducible factor HIF-1alpha	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13526	-	-
Mus musculus	Q9QUR7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Pin1	-	Homo sapiens
Pin1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	PIN1 directly interacts with hypoxia-inducible factor HIF-1alpha in human colon cancer cells. PIN1 binding occurs in a phosphorylation-dependent manner, and at both exogenous and endogenous levels. Binding stabilizes the HIF-1alpha protein, resulting in increased transcriptional activity, and upregulating expression of vascular endothelial growth factor. Silencing of PIN1 or pharmacologic inhibition of its activity abrogates the angiogenesis	Homo sapiens
physiological function	PIN1 inhibition dramatically reduces the tumor volume in a subcutaneous mouse xenograft model and angiogenesis as well as hypoxia-induced transcriptional activity of hypoxia-inducible factor HIF-1alpha	Mus musculus

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Release 2023.1 (January 2023)