Literature summary for 5.2.1.8 extracted from

Brenkman, A.B.; de Keizer, P.L.; van den Broek, N.J.; van der Groep, P.; van Diest, P.J.; van der Horst, A.; Smits, A.M.; Burgering, B.M.
The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors (2008), Cancer Res., 68, 7597-7605.

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Application

Application	Comment	Organism
medicine	isoform Pin1 is a critical regulator of p27kip1 through inhibition of Forkhead box O, FOXO4. Oxidative stress induces binding of Pin1 to FOXO4 thereby attenuating its monoubiquitination. Pin1 prevents nuclear FOXO4 accumulation and acts on FOXO through stimulation of the activity of the deubiquitinating enzyme HAUSP/USP7	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
K63A	mutant lacking isomerase activity. Wild-type inhibits FOXO4-induced expression of p27kip1, while mutant K63A does not	Homo sapiens
W34A	cells expressing Pin1 mutant W34A do not inhibit FOXO4 relocalization to the nucleus upon stimulation with hydrogen peroxide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
NIH-3T3-A14 cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
More	isoform Pin1 is a critical regulator of p27kip1 through inhibition of Forkhead box O, FOXO4. Oxidative stress induces binding of Pin1 to FOXO4 thereby attenuating its monoubiquitination. Pin1 prevents nuclear FOXO4 accumulation and acts on FOXO through stimulation of the activity of the deubiquitinating enzyme HAUSP/USP7	Homo sapiens

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Release 2023.1 (January 2023)