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Literature summary for 5.2.1.8 extracted from

  • Barth, S.; Nesper, J.; Hasgall, P.A.; Wirthner, R.; Nytko, K.J.; Edlich, F.; Katschinski, D.M.; Stiehl, D.P.; Wenger, R.H.; Camenisch, G.
    The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability (2007), Mol. Cell. Biol., 27, 3758-3768.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14318 isoform FKBP38
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Subunits

Subunits Comment Organism
More isoform FKBP38 interacts with prolyl-4-hydroxylase domain-containing enzyme PHD2 by association of their N-terminal regions. FKBP38 does not interact with PHD1 or PHD3. Depletion of FKBP38 by RNAi results in increased PHD2 hydroxylation activity and decreased protein levels of PHD2 substrate HIF. downregulation of FKBP38 does not affect PHD2 mRNA levels, but prolongs PHD2 protein stability Homo sapiens

Synonyms

Synonyms Comment Organism
FKBP38
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 Homo sapiens