Protein Variants | Comment | Organism |
---|---|---|
additional information | introduction of point mutations in the prolyl-peptidyl isomerase motif of CyPA. Downregulation of host CyPA by RNA interference, and mutations in viral NS5B, that confers cyclosporine-resistant binding to CyPA, contribute to the cyclosporine resistance of the replicons harboring these mutations | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclosporin A | forms an inhibitory complex with cyclophilin. CyPA is a major intracellular target of cyclosporines | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | incorporation of the HCV polymerase into the replication complex depends on its interaction with a cellular chaperone protein, cyclosporine inhibits HCV replication by blocking this critical interaction and the PPIase activity of CyPA, modeling of the pathway, overview. CyPA is associated with CRC-incorporated HCV replicase in a cyclosporine-sensitive manner | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Huh-7.5 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | incorporation of the HCV polymerase into the replication complex depends on its interaction with a cellular chaperone protein, cyclosporine inhibits HCV replication by blocking this critical interaction and the PPIase activity of CyPA, modeling of the pathway, overview. CyPA is associated with CRC-incorporated HCV replicase in a cyclosporine-sensitive manner | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cyclophilin A | - |
Homo sapiens |
CyPA | - |
Homo sapiens |
More | the enzyme belongs to the CyP family of proteins | Homo sapiens |
prolyl-peptidyl isomerase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | cyclophilin A is an essential cofactor for hepatitis C virus infection and the intracellular target of cyclosporines anti-HCV effect, mechanism by which CyPA facilitates HCV replication, overview | Homo sapiens |