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Information on EC 4.2.1.3 - aconitate hydratase
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4.2.1.3 aconitate hydrataseIUBMB Comments
Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds.
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Word Map
- 4.2.1.3
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iron-sulfur
- transferrin
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tricarboxylic
- dismutase
- fe-s
- succinate
- tca
- malate
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citric
- cardiac
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rna-binding
- neurodegenerative
- frataxin
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krebs
- fumarase
- friedreich
- heme
- ataxia
- parkinson
- overload
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iron-dependent
- alpha-ketoglutarate
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stem-loops
- fluorocitrate
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bioenergetics
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ferroportin
-
county
- hepcidin
- peroxynitrite
- mnsod
- fluoroacetate
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georgia
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cluster-containing
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iron-deficient
- iscu
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iron-replete
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iron-induced
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iron-mediated
- alabama
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kennedy
-
itaconic
-
ferrochelatase
- cubane
-
desulfurase
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nadp-isocitrate
-
rna-protein
-
iron-related
-
soxrs
- l-ferritin
- isopropylmalate
- medicine
- environmental protection
- synthesis
- biotechnology
The enzyme appears in viruses and cellular organisms
Synonyms
aconitase, iron regulatory protein, irp-1, ire-bp, macon, iron regulatory protein 1, aconitate hydratase, cytoplasmic aconitase, aconitase a, c-aconitase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AcnA
AcnA3
AcnB
ACO
Aco1
Aco2
aconitase
aconitase B
aconitase/2-methylaconitate hydratase
Aconitate hydratase
cis-aconitase
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citB
citrate hydro-lyase
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EC 4.2.1.4
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formerly
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Ferritin repressor protein
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hydratase, aconitate
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IP210
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IRE-BP
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Iron regulatory protein
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iron regulatory protein 1
iron-responsive element binding protein
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IRP
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IRP-1
IRP1
Major iron-containing protein
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MICP
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SPBP4H10.15
aconitase
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Aconitate hydratase
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Aconitate hydratase
bifunctional enzyme: aconitate hydratase 2/2-methylisocitrate dehydratase
Aconitate hydratase
bifunctional enzyme: aconitate hydratase 2/2-methylisocitrate dehydratase
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IRP1
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
citrate = cis-aconitate + H2O
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds.
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CAS REGISTRY NUMBER
COMMENTARY
9024-25-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2R,3S)-2-methylisocitrate
(Z)-2-methyl-aconitate + H2O
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r
(2R,3S)-2-methylisocitrate
(Z)-2-methylaconitate + H2O
enzyme is involved in pathway of oxidation of propionate to pyruvate
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?
(2R,3S)-2-methylisocitrate
(Z)-2-methylaconitate + H2O
enzyme is involved in pathway of oxidation of propionate to pyruvate
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?
(Z)-2-methylaconitate
2-methylisocitrate
the enzyme is involved in the methylcitric acid cycle
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?
(Z)-2-methylaconitate
2-methylisocitrate
the enzyme is involved in the methylcitric acid cycle
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?
(Z)-2-methylaconitate + H2O
(2R,3S)-2-methylisocitrate
enzyme is involved in pathway of oxidation of propionate to pyruvate
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r
(Z)-2-methylaconitate + H2O
(2R,3S)-2-methylisocitrate
enzyme is involved in pathway of oxidation of propionate to pyruvate
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r
cis-aconitate + H2O
isocitrate
aconitase catalyzes a reversible isomerization of citrate into isocitrate in the Krebs cycle
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r
cis-aconitate + H2O
isocitrate
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?
citrate
cis-aconitate + H2O
aconitase catalyzes a reversible isomerization of citrate into isocitrate in the Krebs cycle
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r
citrate
cis-aconitate + H2O
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?
isocitrate
cis-aconitate + H2O
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?
additional information
?
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additionally to catalytic activity, enzyme is able to bind specifically the 5 UTP of the Arabidopsis chloroplastic CuZn superoxide dismutase 2 mRNA. Enzyme does not bind an iron responsive element of the human ferritin gene
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?
additional information
?
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bifunctional protein, showing aconitase activity in presence of iron and RNA binding activity when cells are iron-deprived
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?
additional information
?
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amino acid residues Arg741 and Gln745 play great role in the aconitase function
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?
additional information
?
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aconitase binds bound to the citrate synthase 5' leader RNA in vitro
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?
additional information
?
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amino acid residues Arg741 and Gln745 play great role in the aconitase function
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?
additional information
?
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Bacteroides fragilis has two separate pathways to generate alpha-ketoglutarate, either of which is sufficient for growth, a heme-dependent pathway and a heme-independent pathway. Aconitase is involved in the heme-independent pathway
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?
additional information
?
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Bacteroides fragilis has two separate pathways to generate alpha-ketoglutarate, either of which is sufficient for growth, a heme-dependent pathway and a heme-independent pathway. Aconitase is involved in the heme-independent pathway
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?
additional information
?
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iron-responsive element binding protein is required in the posttranscriptional regulation of ferritin mRNA translation and stabilization of transferrin receptor mRNA
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?
additional information
?
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isoform IRP-1A binds in vitro both Drosophila ferritin iron-responsive element and human ferritin iron-responsive element in the presence of a reducing agent
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?
additional information
?
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isoform IRP-1A binds in vitro both Drosophila ferritin iron-responsive element and human ferritin iron-responsive element in the presence of a reducing agent
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?
additional information
?
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isoform IRP-1A binds in vitro both Drosophila ferritin iron-responsive element and human ferritin iron-responsive element in the presence of a reducing agent
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?
additional information
?
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no detectable activity with (2S,3S)-methylcitrate
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?
additional information
?
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no detectable activity with (2S,3S)-methylcitrate
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?
additional information
?
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aconitase B is the major isoenzyme which is synthesized earlier in the growth cycle than aconitase A and is subject to catabolite and anaerobic repression
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?
additional information
?
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the HEAT-like domain, implies a role in protein-protein recognition
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?
additional information
?
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the HEAT-like domain, implies a role in protein-protein recognition
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?
additional information
?
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aconitase B is the major citric acid cycle aconitase and also a post-transcriptional regulator
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?
additional information
?
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weak interactions, which affects structure and function of the proteins, of aconitase B and isocitrate dehydrogenase, overview. Two monomeric AcnB regions associate with the homodimeric ICDH region. The versatile architecture of AcnB may alter the metabolic process involving the Krebs cycle
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?
additional information
?
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the active sites within ICDH-AcnB catalyze the three consecutive reactions, in which citrate is converted to 2-oxoglutarate, via cisaconitate and isocitrate
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?
additional information
?
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the substrate binding may induce a rearrangement of their relative positions. Such a conformational change may result in the negative cooperativity
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?
additional information
?
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the substrate binding may induce a rearrangement of their relative positions. Such a conformational change may result in the negative cooperativity
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?
additional information
?
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the substrate binding may induce a rearrangement of their relative positions. Such a conformational change may result in the negative cooperativity
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?